ENSMUSG00000042042


Mus musculus

Features
Gene ID: ENSMUSG00000042042
  
Biological name :Csgalnact2
  
Synonyms : Chondroitin sulfate N-acetylgalactosaminyltransferase 2 / Csgalnact2 / Q8C1F4
  
Possible biological names infered from orthology : Q8N6G5
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F1
Gene start: 118107452
Gene end: 118139140
  
Corresponding Affymetrix probe sets: 10547217 (MoGene1.0st)   1424431_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039819
Ensembl peptide - ENSMUSP00000116371
NCBI entrez gene - 78752     See in Manteia.
MGI - MGI:1926002
RefSeq - XM_006506778
RefSeq - NM_030165
RefSeq - XM_006506776
RefSeq - XM_006506777
RefSeq Peptide - NP_084441
swissprot - D3Z5Q0
swissprot - Q8C1F4
Ensembl - ENSMUSG00000042042
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 csgalnact2ENSDARG00000061400Danio rerio
 CSGALNACT2ENSGALG00000002543Gallus gallus
 Q8N6G5ENSG00000169826Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BJQ9 / Csgalnact1 / Chondroitin sulfate N-acetylgalactosaminyltransferase 1 / Q8TDX6*ENSMUSG0000003635658
Chsy3 / Q5DTK1 / Chondroitin sulfate synthase 3 / Q70JA7*ENSMUSG0000005815229
Chsy1 / Q6ZQ11 / Chondroitin sulfate synthase 1 / Q86X52*ENSMUSG0000003264027
Chpf / Q6IQX7 / Chondroitin sulfate synthase 2 / Q8IZ52* / chondroitin polymerizing factor*ENSMUSG0000003299719
Chpf2 / chondroitin polymerizing factor 2 / Q9P2E5*ENSMUSG0000003818118
Q6L8S8 / B4galnt3 / Beta-1,4-N-acetylgalactosaminyltransferase 3 / Q6L9W6* / beta-1,4-N-acetyl-galactosaminyltransferase 3*ENSMUSG0000004137218
Q766D5 / B4galnt4 / N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 / Q76KP1* / beta-1,4-N-acetyl-galactosaminyltransferase 4*ENSMUSG0000005562918


Protein motifs (from Interpro)
Interpro ID Name
 IPR008428  Chondroitin N-acetylgalactosaminyltransferase
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030166 proteoglycan biosynthetic process IEA
 biological_processGO:0050650 chondroitin sulfate proteoglycan biosynthetic process IEA
 biological_processGO:0050651 dermatan sulfate proteoglycan biosynthetic process IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 molecular_functionGO:0008376 acetylgalactosaminyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Chondroitin sulfate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rimbp2tm1.2Geno/Rimbp2tm1.2Geno,Tspoap1tm1.2Geno/Tspoap1tm1.2Geno
Genetic Background: involves: C57BL/6

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
Show

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0008910 thin epiphysis "thinner than normal part of the long bones that initially develops from a distinct ossification center than the shaft" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0014101 decreased chondrocyte proliferation "decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]
Show

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0014103 increased chondrocyte apoptosis "increased number of chondrocytes undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr