ENSMUSG00000036356


Mus musculus

Features
Gene ID: ENSMUSG00000036356
  
Biological name :Csgalnact1
  
Synonyms : Chondroitin sulfate N-acetylgalactosaminyltransferase 1 / Csgalnact1 / Q8BJQ9
  
Possible biological names infered from orthology : Q8TDX6
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B3.3
Gene start: 68356781
Gene end: 68735146
  
Corresponding Affymetrix probe sets: 10579012 (MoGene1.0st)   1452365_at (Mouse Genome 430 2.0 Array)   1452366_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077459
Ensembl peptide - ENSMUSP00000116134
Ensembl peptide - ENSMUSP00000119817
NCBI entrez gene - 234356     See in Manteia.
MGI - MGI:2442354
RefSeq - XM_011242290
RefSeq - NM_001252623
RefSeq - NM_172753
RefSeq - XM_006509627
RefSeq - XM_006509628
RefSeq - XM_006509629
RefSeq - XM_006509630
RefSeq - XM_006509624
RefSeq - XM_006509625
RefSeq - XM_006509626
RefSeq Peptide - NP_001239552
RefSeq Peptide - NP_766341
swissprot - Q8BJQ9
swissprot - A0A0R4J1S7
Ensembl - ENSMUSG00000036356
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 csgalnact1aENSDARG00000040535Danio rerio
 csgalnact1bENSDARG00000089233Danio rerio
 CSGALNACT1ENSGALG00000010125Gallus gallus
 Q8TDX6ENSG00000147408Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8C1F4 / Csgalnact2 / Chondroitin sulfate N-acetylgalactosaminyltransferase 2 / Q8N6G5*ENSMUSG0000004204259
Chsy3 / Q5DTK1 / Chondroitin sulfate synthase 3 / Q70JA7*ENSMUSG0000005815231
Chsy1 / Q6ZQ11 / Chondroitin sulfate synthase 1 / Q86X52*ENSMUSG0000003264028
Q6L8S8 / B4galnt3 / Beta-1,4-N-acetylgalactosaminyltransferase 3 / Q6L9W6* / beta-1,4-N-acetyl-galactosaminyltransferase 3*ENSMUSG0000004137219
Chpf / Q6IQX7 / Chondroitin sulfate synthase 2 / Q8IZ52* / chondroitin polymerizing factor*ENSMUSG0000003299718
Chpf2 / chondroitin polymerizing factor 2 / Q9P2E5*ENSMUSG0000003818118
Q766D5 / B4galnt4 / N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 / Q76KP1* / beta-1,4-N-acetyl-galactosaminyltransferase 4*ENSMUSG0000005562918


Protein motifs (from Interpro)
Interpro ID Name
 IPR008428  Chondroitin N-acetylgalactosaminyltransferase
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001958 endochondral ossification IMP
 biological_processGO:0019276 UDP-N-acetylgalactosamine metabolic process ISS
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030204 chondroitin sulfate metabolic process IMP
 biological_processGO:0030206 chondroitin sulfate biosynthetic process ISS
 biological_processGO:0046398 UDP-glucuronate metabolic process ISO
 biological_processGO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ISO
 biological_processGO:0051216 cartilage development IMP
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 molecular_functionGO:0008376 acetylgalactosaminyltransferase activity IEA
 molecular_functionGO:0008955 peptidoglycan glycosyltransferase activity ISO
 molecular_functionGO:0015020 glucuronosyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISO
 molecular_functionGO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISO


Pathways (from Reactome)
Pathway description
Chondroitin sulfate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000071 axial skeleton hypoplasia "reduced cell number in the skeletal elements of the trunk" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:55583]
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Allelic Composition: T t+/T+ th45
Genetic Background: Not Specified

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: T t+/T+ th45
Genetic Background: Not Specified

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari
Genetic Background: involves: C57BL/6J

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: T t+/T+ th45
Genetic Background: Not Specified

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: T t+/T+ th45
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: T t+/T+ th45
Genetic Background: Not Specified

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Erbb4tm1Grl/Erbb4tm1Grl,Tg(Myh6-ERBB4)HT2Gass/0
Genetic Background: B6.Cg-Erbb4tm1Grl Tg(Myh6-ERBB4)HT2Gass

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari
Genetic Background: involves: C57BL/6J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari
Genetic Background: involves: C57BL/6J

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: T t+/T+ th45
Genetic Background: Not Specified

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: T t+/T+ th45
Genetic Background: Not Specified

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari
Genetic Background: involves: C57BL/6J

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari
Genetic Background: involves: C57BL/6J

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: T t+/T+ th45
Genetic Background: Not Specified

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari
Genetic Background: involves: C57BL/6J

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari
Genetic Background: involves: C57BL/6J

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
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Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0008910 thin epiphysis "thinner than normal part of the long bones that initially develops from a distinct ossification center than the shaft" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari
Genetic Background: involves: C57BL/6J

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari,Csgalnact2tm1.2Staka/Csgalnact2tm1.2Staka
Genetic Background: involves: C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0014101 decreased chondrocyte proliferation "decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]
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Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0014103 increased chondrocyte apoptosis "increased number of chondrocytes undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Csgalnact1tm1Nari/Csgalnact1tm1Nari,Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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