MP:0000465 | gastrointestinal hemorrhage | "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0000488 | abnormal intestinal epithelium morphology | "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0000490 | abnormal crypts of Lieberkuhn morphology | "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0000511 | abnormal intestinal mucosa morphology | "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0000512 | intestinal ulcer | "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0003449 | abnormal intestinal goblet cells | "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0008537 | increased susceptibility to induced colitis | "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0008705 | increased interleukin-6 secretion | "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0008722 | abnormal chemokine secretion | "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0009766 | increased sensitivity to xenobiotic induced morbidity/mortality | "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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MP:0010377 | abnormal gut flora balance | "anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
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