ENSMUSG00000042250


Mus musculus

Features
Gene ID: ENSMUSG00000042250
  
Biological name :Pglyrp4
  
Synonyms : peptidoglycan recognition protein 4 / Pglyrp4 / Q0VB07
  
Possible biological names infered from orthology : Q96LB8
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 90726906
Gene end: 90741517
  
Corresponding Affymetrix probe sets: 10493834 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000040755
Ensembl peptide - ENSMUSP00000128113
NCBI entrez gene - 384997     See in Manteia.
MGI - MGI:2686324
RefSeq - XM_017319632
RefSeq - NM_001165968
RefSeq - NM_207263
RefSeq Peptide - NP_001159440
RefSeq Peptide - NP_997146
swissprot - Q0VB07
swissprot - B7ZMZ4
Ensembl - ENSMUSG00000042250
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pglyrp5ENSDARG00000068382Danio rerio
 Q96LB8ENSG00000163218Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A1A547 / Pglyrp3 / Peptidoglycan recognition protein 3 / Q96LB9*ENSMUSG0000004224454
Q8VCS0 / Pglyrp2 / N-acetylmuramoyl-L-alanine amidase / Q96PD5* / peptidoglycan recognition protein 2*ENSMUSG0000007956324
O88593 / Pglyrp1 / Peptidoglycan recognition protein 1 / O75594*ENSMUSG0000003041322


Protein motifs (from Interpro)
Interpro ID Name
 IPR002502  N-acetylmuramoyl-L-alanine amidase domain
 IPR006619  Peptidoglycan recognition protein family domain, metazoa/bacteria
 IPR015510  Peptidoglycan recognition protein
 IPR036505  N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002221 pattern recognition receptor signaling pathway IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0009253 peptidoglycan catabolic process IEA
 biological_processGO:0016045 detection of bacterium IEA
 biological_processGO:0031640 killing of cells of other organism IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IMP
 biological_processGO:0032827 negative regulation of natural killer cell differentiation involved in immune response IMP
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0044117 growth of symbiont in host IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0051714 positive regulation of cytolysis in other organism IEA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008745 N-acetylmuramoyl-L-alanine amidase activity IEA
 molecular_functionGO:0016019 peptidoglycan receptor activity IEA
 molecular_functionGO:0042834 peptidoglycan binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0010377 abnormal gut flora balance "anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042244 A1A547 / Pglyrp3 / Peptidoglycan recognition protein 3 / Q96LB9*  / complex
 ENSMUSG00000042250 Q0VB07 / Pglyrp4 / peptidoglycan recognition protein 4 / Q96LB8*  / complex






 

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