ENSMUSG00000042717


Mus musculus

Features
Gene ID: ENSMUSG00000042717
  
Biological name :Ppp1r3a
  
Synonyms : Ppp1r3a / Protein phosphatase 1 regulatory subunit 3A / Q99MR9
  
Possible biological names infered from orthology : Q16821
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A1
Gene start: 14713977
Gene end: 14755274
  
Corresponding Affymetrix probe sets: 10543233 (MoGene1.0st)   1422108_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049054
NCBI entrez gene - 140491     See in Manteia.
MGI - MGI:2153588
RefSeq - NM_080464
RefSeq Peptide - NP_536712
swissprot - Q99MR9
Ensembl - ENSMUSG00000042717
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1r3aaENSDARG00000090468Danio rerio
 ppp1r3abENSDARG00000088813Danio rerio
 PPP1R3AENSGALG00000009435Gallus gallus
 Q16821ENSG00000154415Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7TMB3 / Ppp1r3c / Protein phosphatase 1 regulatory subunit 3C / Q9UQK1*ENSMUSG000000672797
Q8C767 / Ppp1r3b / Protein phosphatase 1 regulatory subunit 3B / Q86XI6*ENSMUSG000000467946
Ppp1r3d / protein phosphatase 1 regulatory subunit 3D / O95685*ENSMUSG000000499996
Q9CW07 / Ppp1r3g / Protein phosphatase 1 regulatory subunit 3G / B7ZBB8*ENSMUSG000000504236
Ppp1r3e / protein phosphatase 1, regulatory (inhibitor) subunit 3E / Q9H7J1* / protein phosphatase 1 regulatory subunit 3E*ENSMUSG000000724946


Protein motifs (from Interpro)
Interpro ID Name
 IPR005036  CBM21 (carbohydrate binding type-21) domain
 IPR013783  Immunoglobulin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity ISO
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ppp1r3atm2Adpr/Ppp1r3a+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ppp1r3atm1Adpr/Ppp1r3atm1Adpr
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Ppp1r3atm2Adpr/Ppp1r3atm2Adpr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ppp1r3atm2Adpr/Ppp1r3a+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ppp1r3atm1Adpr/Ppp1r3atm1Adpr
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6J)

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0020411 increased abdominal adipose tissue amount "increase in amount of adipose tissue associated with internal organs" [MGI:anna]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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