ENSMUSG00000067279


Mus musculus

Features
Gene ID: ENSMUSG00000067279
  
Biological name :Ppp1r3c
  
Synonyms : Ppp1r3c / Protein phosphatase 1 regulatory subunit 3C / Q7TMB3
  
Possible biological names infered from orthology : Q9UQK1
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C2
Gene start: 36731737
Gene end: 36736653
  
Corresponding Affymetrix probe sets: 10467206 (MoGene1.0st)   1425631_at (Mouse Genome 430 2.0 Array)   1433691_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000084578
NCBI entrez gene - 53412     See in Manteia.
MGI - MGI:1858229
RefSeq - NM_016854
RefSeq Peptide - NP_058550
swissprot - Q7TMB3
Ensembl - ENSMUSG00000067279
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1r3caENSDARG00000071005Danio rerio
 ppp1r3cbENSDARG00000014554Danio rerio
 PPP1R3CENSGALG00000006670Gallus gallus
 Q9UQK1ENSG00000119938Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8C767 / Ppp1r3b / Protein phosphatase 1 regulatory subunit 3B / Q86XI6*ENSMUSG0000004679438
Q99MR9 / Ppp1r3a / Protein phosphatase 1 regulatory subunit 3A / Q16821*ENSMUSG0000004271724
Ppp1r3d / protein phosphatase 1 regulatory subunit 3D / O95685*ENSMUSG0000004999919
Q9CW07 / Ppp1r3g / Protein phosphatase 1 regulatory subunit 3G / B7ZBB8*ENSMUSG0000005042318
Ppp1r3e / protein phosphatase 1, regulatory (inhibitor) subunit 3E / Q9H7J1* / protein phosphatase 1 regulatory subunit 3E*ENSMUSG0000007249417


Protein motifs (from Interpro)
Interpro ID Name
 IPR005036  CBM21 (carbohydrate binding type-21) domain
 IPR013783  Immunoglobulin-like fold
 IPR017434  Protein phosphatase 1 regulatory subunit 3B/C/D, metazoa
 IPR030683  Protein phosphatase 1 regulatory subunit 3C


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0005978 glycogen biosynthetic process IMP
 biological_processGO:0006605 protein targeting TAS
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019888 protein phosphatase regulator activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IPI


Pathways (from Reactome)
Pathway description
Glycogen synthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ppp1r3ctm1Adpr/Ppp1r3ctm1Adpr
Genetic Background: involves: C57BL/6J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Pitx3eyl/Pitx3eyl
Genetic Background: involves: C3H/He * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pitx3eyl/Pitx3eyl
Genetic Background: involves: C3H/He * C57BL/6

Allelic Composition: Ppp1r3ctm1Adpr/Ppp1r3ctm1Adpr
Genetic Background: B6.Cg-Ppp1r3ctm1Adpr

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pitx3eyl/Pitx3eyl
Genetic Background: involves: C3H/He * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Pitx3eyl/Pitx3eyl
Genetic Background: involves: C3H/He * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Ppp1r3ctm1Adpr/Ppp1r3ctm1Adpr
Genetic Background: B6.Cg-Ppp1r3ctm1Adpr

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppp1r3ctm1Adpr/Ppp1r3ctm1Adpr
Genetic Background: B6.Cg-Ppp1r3ctm1Adpr

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pitx3eyl/Pitx3eyl
Genetic Background: involves: C3H/He * C57BL/6

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pitx3eyl/Pitx3eyl
Genetic Background: involves: C3H/He * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pitx3eyl/Pitx3eyl
Genetic Background: involves: C3H/He * C57BL/6

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pitx3eyl/Pitx3eyl
Genetic Background: involves: C3H/He * C57BL/6

Allelic Composition: Ppp1r3ctm1Adpr/Ppp1r3ctm1Adpr
Genetic Background: involves: C57BL/6J

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pitx3eyl/Pitx3eyl
Genetic Background: involves: C3H/He * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pitx3eyl/Pitx3eyl
Genetic Background: involves: C3H/He * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Pitx3eyl/Pitx3eyl
Genetic Background: involves: C3H/He * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gsdma3Fgn/Gsdma3+
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0014063 Lafora bodies "abnormal presence of insoluble periodic acid-Schiff-positive deposits that contain polyglucosan, a poorly branched form of glycogen, seen in familial myoclonic epilepsy; Lafora bodies develop in many tissues, including muscle, liver, and neurons, but it is generally believed that Lafora body accumulation ultimately leads to neuronal cell death" [PMID:20538597]
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Allelic Composition: Ppp1r3ctm1Adpr/Ppp1r3ctm1Adpr
Genetic Background: involves: C57BL/6J

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Ppp1r3ctm1Adpr/Ppp1r3ctm1Adpr
Genetic Background: B6.Cg-Ppp1r3ctm1Adpr

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Pitx3eyl/Pitx3eyl
Genetic Background: involves: C3H/He * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003865 Gys1 / Q9Z1E4 / Glycogen [starch] synthase, muscle / P13807* / glycogen synthase 1*  / reaction / complex
 ENSMUSG00000055493 Epm2a / Q9WUA5 / Laforin / O95278* / EPM2A, laforin glucan phosphatase*  / reaction
 ENSMUSG00000019528 Gyg / Q9R062 / glycogenin / GYG1* / P46976* / glycogenin 1*  / complex / reaction






 

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