ENSMUSG00000049630


Mus musculus
impairedC1ql3behaviordomaincollagensynapseproteinbindingconditionedconditioningcqtriplehelixrepeattumournecrosisfactor-likesuperfamilyregulationorganizationextracellularregiontrimeridenticaldecreasedanxiety-relatedresponsehyperactivitycoordinationtaste

Features
Gene ID: ENSMUSG00000049630
  
Biological name :C1ql3
  
Synonyms : C1ql3 / Complement C1q-like protein 3 / Q9ESN4
  
Possible biological names infered from orthology : complement C1q like 3 / Q5VWW1
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A1
Gene start: 13003457
Gene end: 13011806
  
Corresponding Affymetrix probe sets: 10480139 (MoGene1.0st)   1425175_at (Mouse Genome 430 2.0 Array)   1425176_at (Mouse Genome 430 2.0 Array)   1451620_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056188
NCBI entrez gene - 227580     See in Manteia.
MGI - MGI:2387350
RefSeq - NM_153155
RefSeq Peptide - NP_694795
swissprot - Q9ESN4
Ensembl - ENSMUSG00000049630
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 c1ql3aENSDARG00000010350Danio rerio
 c1ql3bENSDARG00000036483Danio rerio
 C1QL3ENSGALG00000032554Gallus gallus
 C1QL3ENSG00000165985Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C1ql1 / O88992 / C1q-related factor / O75973* / complement C1q like 1*ENSMUSG0000004553274
C1ql2 / Q8CFR0 / Complement C1q-like protein 2 / Q7Z5L3* / complement C1q like 2*ENSMUSG0000003690771
C1ql4 / Q4ZJM9 / Complement C1q-like protein 4 / Q86Z23* / complement C1q like 4*ENSMUSG0000000107664
Q05A80 / Caprin2 / Q6IMN6* / caprin family member 2*ENSMUSG0000003030926
Q9ES30 / C1qtnf3 / Complement C1q tumor necrosis factor-related protein 3 / Q9BXJ4* / C1QTNF3-AMACR* / C1q and TNF related 3* / C1QTNF3-AMACR readthrough (NMD candidate)*ENSMUSG0000005891424
Cbln2 / Q8BGU2 / Cerebellin-2 / Q8IUK8* / cerebellin 2 precursor*ENSMUSG0000002464721
Cbln1 / Q9R171 / Cerebellin-1 Cerebellin [des-Ser1]-cerebellin / P23435* / cerebellin 1 precursor*ENSMUSG0000003165421
Cbln3 / Q9JHG0 / Cerebellin-3 / Q6UW01* / cerebellin 3 precursor*ENSMUSG0000004038021
Cbln4 / Q8BME9 / Cerebellin-4 / Q9NTU7* / cerebellin 4 precursor*ENSMUSG0000006757820
Q60865 / Caprin1 / Q14444* / cell cycle associated protein 1*ENSMUSG0000002718414


Protein motifs (from Interpro)
Interpro ID Name
 IPR001073  C1q domain
 IPR008160  Collagen triple helix repeat
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
cellular component organizationregulation of biological qualitycellular component organizationregulation of biological qualitycellular component organizationregulation of biological qualitycellular component organizationregulation of biological qualitycellular component organizationregulation of biological qualitycellular component organizationregulation of biological qualitycellular component organizationregulation of biological qualitycellular component organizationregulation of biological qualitycellular component organizationregulation of biological qualitycellular component organizationregulation of biological qualitycellular component organizationcellular component organizationregulation of biological qualityregulation of biological quality
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
extracellular regionprotein-containing complexextracellular regionprotein-containing complexextracellular regionprotein-containing complexextracellular regionprotein-containing complexextracellular regionprotein-containing complexextracellular regionprotein-containing complexextracellular regionprotein-containing complexextracellular regionprotein-containing complexextracellular regionprotein-containing complexextracellular regionprotein-containing complexextracellular regionextracellular regionprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0050807 regulation of synapse organization IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005581 collagen trimer IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
behavior/neurological phenotypenervous system phenotypebehavior/neurological phenotypenervous system phenotypebehavior/neurological phenotypenervous system phenotypebehavior/neurological phenotypenervous system phenotypebehavior/neurological phenotypenervous system phenotypebehavior/neurological phenotypenervous system phenotypebehavior/neurological phenotypenervous system phenotypebehavior/neurological phenotypenervous system phenotypebehavior/neurological phenotypenervous system phenotypebehavior/neurological phenotypenervous system phenotypebehavior/neurological phenotypebehavior/neurological phenotypenervous system phenotypenervous system phenotype
IDPhenotypeDefinition Genetic BG
 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

Allelic Composition: C1ql3tm1.2Sud/C1ql3+
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

Allelic Composition: C1ql3tm1.2Sud/C1ql3+
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0002805 abnormal conditioned taste aversion behavior "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

Allelic Composition: C1ql3tm1.2Sud/C1ql3tm1.2Sud
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

Allelic Composition: C1ql3tm1.2Sud/C1ql3+
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: C1ql3tm1.2Sud/C1ql3tm1.2Sud
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

 MP:0020357 abnormal excitatory synapse morphology "any structural anomaly of a synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell" [GO:0060076]
Show

Allelic Composition: C1ql3tm1.2Sud/C1ql3tm1.2Sud
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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