ENSMUSG00000049939


Mus musculus
leucine-richproteinLrrc4repeatdomainsynapsemembranesubtypeimmunoglobulinimmunoglobulin-likeregulationsuperfamilykinaseactivityorganizationpostsynapticspinen-terminalcysteine-richflankingregionc-terminaltypicali-setfoldrepeat-containingcytokine-mediatedsignalingpathwayjak-statcascade

Features
Gene ID: ENSMUSG00000049939
  
Biological name :Lrrc4
  
Synonyms : Leucine-rich repeat-containing protein 4 / Lrrc4 / Q99PH1
  
Possible biological names infered from orthology : leucine rich repeat containing 4 / Q9HBW1
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A3.3
Gene start: 28661831
Gene end: 28831747
  
Corresponding Affymetrix probe sets: 10543544 (MoGene1.0st)   1416097_at (Mouse Genome 430 2.0 Array)   1435832_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129497
Ensembl peptide - ENSMUSP00000062158
NCBI entrez gene - 192198     See in Manteia.
MGI - MGI:2182081
RefSeq - NM_138682
RefSeq Peptide - NP_619623
swissprot - E9PUX8
swissprot - Q99PH1
Ensembl - ENSMUSG00000049939
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrc4.1ENSDARG00000069402Danio rerio
 lrrc4.2ENSDARG00000003020Danio rerio
 LRRC4ENSG00000128594Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrrc4b / P0C192 / Leucine-rich repeat-containing protein 4B / Q9NT99* / leucine rich repeat containing 4B*ENSMUSG0000004708557
Lrrc4c / Q8C031 / Leucine-rich repeat-containing protein 4C / Q9HCJ2* / leucine rich repeat containing 4C*ENSMUSG0000005058755
Lingo4 / leucine rich repeat and Ig domain containing 4 / Q6UY18*ENSMUSG0000004450523
Lingo2 / Q3URE9 / leucine rich repeat and Ig domain containing 2 / Q7L985*ENSMUSG0000004508323
Lingo3 / Q6GQU6 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 / P0C6S8* / leucine rich repeat and Ig domain containing 3*ENSMUSG0000005106723
Lrrn2 / leucine rich repeat protein 2, neuronal / O75325* / leucine rich repeat neuronal 2*ENSMUSG0000002644322
Lingo1 / Q9D1T0 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 / Q96FE5* / leucine rich repeat and Ig domain containing 1*ENSMUSG0000004955622
Lrrn1 / Q61809 / Leucine-rich repeat neuronal protein 1 / Q6UXK5* / leucine rich repeat neuronal 1*ENSMUSG0000003464821
Lrrn3 / Q8CBC6 / Leucine-rich repeat neuronal protein 3 / Q9H3W5* / leucine rich repeat neuronal 3*ENSMUSG0000003629521
Lrfn1 / Q2WF71 / Leucine-rich repeat and fibronectin type III domain-containing protein 1 / Q9P244* / leucine rich repeat and fibronectin type III domain containing 1*ENSMUSG0000003060019
Lrfn5 / Q8BXA0 / Leucine-rich repeat and fibronectin type-III domain-containing protein 5 / Q96NI6* / leucine rich repeat and fibronectin type III domain containing 5*ENSMUSG0000003565319
Lrfn2 / Q80TG9 / Leucine-rich repeat and fibronectin type-III domain-containing protein 2 / Q9ULH4* / leucine rich repeat and fibronectin type III domain containing 2*ENSMUSG0000004049019
Lrfn3 / Q8BLY3 / Leucine-rich repeat and fibronectin type-III domain-containing protein 3 / Q9BTN0* / leucine rich repeat and fibronectin type III domain containing 3*ENSMUSG0000003695718
Lrfn4 / Q80XU8 / Leucine-rich repeat and fibronectin type-III domain-containing protein 4 / Q6PJG9* / leucine rich repeat and fibronectin type III domain containing 4*ENSMUSG0000004504517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR026882  Leucine-rich repeat-containing protein 4
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationresponse to chemicalcellular response to stimuluscellular component organizationregulation of biological qualitymacromolecule localizationcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationresponse to chemicalcellular response to stimuluscellular component organizationregulation of biological qualitymacromolecule localizationcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationresponse to chemicalcellular response to stimuluscellular component organizationregulation of biological qualitymacromolecule localizationcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationresponse to chemicalcellular response to stimuluscellular component organizationregulation of biological qualitymacromolecule localizationcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationresponse to chemicalcellular response to stimuluscellular component organizationregulation of biological qualitymacromolecule localizationcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationresponse to chemicalcellular response to stimuluscellular component organizationregulation of biological qualitymacromolecule localizationcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationresponse to chemicalcellular response to stimuluscellular component organizationregulation of biological qualitymacromolecule localizationcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationresponse to chemicalcellular response to stimuluscellular component organizationregulation of biological qualitymacromolecule localizationcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationresponse to chemicalcellular response to stimuluscellular component organizationregulation of biological qualitymacromolecule localizationcellular localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell communicationresponse to chemicalcellular response to stimuluscellular component organizationregulation of biological qualitymacromolecule localizationcellular localizationnitrogen conitrogen compound metabolic processcellular mecellular metabolic processprimary metprimary metabolic processregulation regulation of molecular functionorganic suborganic substance metabolic processcell communcell communicationresponse toresponse to chemicalcellular recellular response to stimuluscellular cocellular component organizationregulation regulation of biological qualitymacromolecumacromolecule localizationcellular locellular localization
enzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityenzyme regulator activityprotein bindingprotein binding
cellmembranecell junctionsynapsecellmembranecell junctionsynapsecellmembranecell junctionsynapsecellmembranecell junctionsynapsecellmembranecell junctionsynapsecellmembranecell junctionsynapsecellmembranecell junctionsynapsecellmembranecell junctionsynapsecellmembranecell junctionsynapsecellmembranecell junctionsynapsecellcellmembranemembranecell junctioncell junctionsynapsesynapse
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0050807 regulation of synapse organization IMP
 biological_processGO:0050808 synapse organization IDA
 biological_processGO:0097119 postsynaptic density protein 95 clustering IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0044309 neuron spine IDA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 cellular_componentGO:0060076 excitatory synapse IDA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
behavior/neurological phenotypehearing/ear phenotypebehavior/neurological phenotypehearing/ear phenotypebehavior/neurological phenotypehearing/ear phenotypebehavior/neurological phenotypehearing/ear phenotypebehavior/neurological phenotypehearing/ear phenotypebehavior/neurological phenotypehearing/ear phenotypebehavior/neurological phenotypehearing/ear phenotypebehavior/neurological phenotypehearing/ear phenotypebehavior/neurological phenotypehearing/ear phenotypebehavior/neurological phenotypehearing/ear phenotypebehavior/neurological phenotypebehavior/neurological phenotypehearing/ear phenotypehearing/ear phenotype
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
Show

Allelic Composition: Ttrtm1Wsb/Ttr+
Genetic Background: involves: 129S/SvEv * MF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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