ENSMUSG00000050587


Mus musculus

Features
Gene ID: ENSMUSG00000050587
  
Biological name :Lrrc4c
  
Synonyms : Leucine-rich repeat-containing protein 4C / Lrrc4c / Q8C031
  
Possible biological names infered from orthology : leucine rich repeat containing 4C / Q9HCJ2
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E1
Gene start: 96318169
Gene end: 97631666
  
Corresponding Affymetrix probe sets: 10474096 (MoGene1.0st)   1437201_at (Mouse Genome 430 2.0 Array)   1437825_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125218
Ensembl peptide - ENSMUSP00000128490
Ensembl peptide - ENSMUSP00000130984
Ensembl peptide - ENSMUSP00000131795
NCBI entrez gene - 241568     See in Manteia.
MGI - MGI:2442636
RefSeq - XM_017318140
RefSeq - NM_001289742
RefSeq - NM_001289743
RefSeq - NM_001289744
RefSeq - NM_178725
RefSeq - XM_006499479
RefSeq - XM_017318139
RefSeq Peptide - NP_001276673
RefSeq Peptide - NP_848840
RefSeq Peptide - NP_001276671
RefSeq Peptide - NP_001276672
swissprot - Q8C031
swissprot - E9QA73
Ensembl - ENSMUSG00000050587
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrc4cENSDARG00000113411Danio rerio
 si:dkey-6l15.1ENSDARG00000016739Danio rerio
 LRRC4CENSGALG00000007948Gallus gallus
 LRRC4CENSG00000148948Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrrc4b / P0C192 / Leucine-rich repeat-containing protein 4B / Q9NT99* / leucine rich repeat containing 4B*ENSMUSG0000004708564
Lrrc4 / Q99PH1 / Leucine-rich repeat-containing protein 4 / Q9HBW1* / leucine rich repeat containing 4*ENSMUSG0000004993956
Lingo2 / Q3URE9 / leucine rich repeat and Ig domain containing 2 / Q7L985*ENSMUSG0000004508325
Lingo1 / Q9D1T0 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 / Q96FE5* / leucine rich repeat and Ig domain containing 1*ENSMUSG0000004955625
Lingo3 / Q6GQU6 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 / P0C6S8* / leucine rich repeat and Ig domain containing 3*ENSMUSG0000005106725
Lingo4 / leucine rich repeat and Ig domain containing 4 / Q6UY18*ENSMUSG0000004450523
Lrrn1 / Q61809 / Leucine-rich repeat neuronal protein 1 / Q6UXK5* / leucine rich repeat neuronal 1*ENSMUSG0000003464822
Lrrn3 / Q8CBC6 / Leucine-rich repeat neuronal protein 3 / Q9H3W5* / leucine rich repeat neuronal 3*ENSMUSG0000003629522
Lrfn2 / Q80TG9 / Leucine-rich repeat and fibronectin type-III domain-containing protein 2 / Q9ULH4* / leucine rich repeat and fibronectin type III domain containing 2*ENSMUSG0000004049022
Lrrn2 / leucine rich repeat protein 2, neuronal / O75325* / leucine rich repeat neuronal 2*ENSMUSG0000002644321
Lrfn1 / Q2WF71 / Leucine-rich repeat and fibronectin type III domain-containing protein 1 / Q9P244* / leucine rich repeat and fibronectin type III domain containing 1*ENSMUSG0000003060021
Lrfn5 / Q8BXA0 / Leucine-rich repeat and fibronectin type-III domain-containing protein 5 / Q96NI6* / leucine rich repeat and fibronectin type III domain containing 5*ENSMUSG0000003565321
Lrfn3 / Q8BLY3 / Leucine-rich repeat and fibronectin type-III domain-containing protein 3 / Q9BTN0* / leucine rich repeat and fibronectin type III domain containing 3*ENSMUSG0000003695719
Lrfn4 / Q80XU8 / Leucine-rich repeat and fibronectin type-III domain-containing protein 4 / Q6PJG9* / leucine rich repeat and fibronectin type III domain containing 4*ENSMUSG0000004504518


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR026878  Leucine-rich repeat-containing protein 4C
 IPR026906  Leucine rich repeat 5
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0050770 regulation of axonogenesis ISS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Cdkn2atm2.1Brn/Cdkn2atm2.1Brn,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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