ENSMUSG00000052430


Mus musculus

Features
Gene ID: ENSMUSG00000052430
  
Biological name :Bmpr1b
  
Synonyms : Bmpr1b / Mus musculus bone morphotic protein receptor, type 1B (Bmpr1b), transcript variant 6, mRNA. / P36898
  
Possible biological names infered from orthology : bone morphogenetic protein receptor type 1B / O00238
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H1
Gene start: 141837136
Gene end: 142169425
  
Corresponding Affymetrix probe sets: 10502451 (MoGene1.0st)   1422872_at (Mouse Genome 430 2.0 Array)   1437312_at (Mouse Genome 430 2.0 Array)   1443720_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029948
Ensembl peptide - ENSMUSP00000101837
Ensembl peptide - ENSMUSP00000101839
Ensembl peptide - ENSMUSP00000117478
Ensembl peptide - ENSMUSP00000096167
NCBI entrez gene - 12167     See in Manteia.
MGI - MGI:107191
RefSeq - XM_011240002
RefSeq - NM_001277220
RefSeq - NM_001355043
RefSeq - NM_007560
RefSeq - XM_006500939
RefSeq - XM_006500940
RefSeq - XM_006500942
RefSeq - XM_006500943
RefSeq - XM_006500944
RefSeq - XM_011240001
RefSeq - NM_001277216
RefSeq - NM_001277217
RefSeq - NM_001277218
RefSeq Peptide - NP_001264146
RefSeq Peptide - NP_001264147
RefSeq Peptide - NP_001264149
RefSeq Peptide - NP_001341972
RefSeq Peptide - NP_031586
RefSeq Peptide - NP_001264145
swissprot - B2RRZ4
swissprot - D6RET5
swissprot - P36898
Ensembl - ENSMUSG00000052430
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmpr1baENSDARG00000104100Danio rerio
 bmpr1bbENSDARG00000102742Danio rerio
 BMPR1BENSGALG00000012216Gallus gallus
 BMPR1BENSG00000138696Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bmpr1a / P36895 / Bone morphotic protein receptor type-1A / P36894* / bone morphogenetic protein receptor type 1A*ENSMUSG0000002179672
Q64729 / Tgfbr1 / transforming growth factor, beta receptor I / P36897* / transforming growth factor beta receptor 1*ENSMUSG0000000761351
Acvr1b / Q61271 / Activin receptor type-1B / P36896* / activin A receptor type 1B*ENSMUSG0000000053250
Acvr1c / Q8K348 / Activin receptor type-1C / Q8NER5* / activin A receptor type 1C*ENSMUSG0000002683448
Acvr1 / P37172 / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA. / Q04771* / activin A receptor type 1*ENSMUSG0000002683647
Acvrl1 / Q61288 / Serine/threonine-protein kinase receptor R3 / P37023* / activin A receptor like type 1*ENSMUSG0000000053043
Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*ENSMUSG0000005215529
Q62312 / Tgfbr2 / transforming growth factor, beta receptor II / P37173* / transforming growth factor beta receptor 2*ENSMUSG0000003244028
Bmpr2 / O35607 / Bone morphotic protein receptor type-2 / Q13873* / bone morphogenetic protein receptor type 2*ENSMUSG0000006733628
Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*ENSMUSG0000006139327
Amhr2 / Q8K592 / Mus musculus anti-Mullerian hormone type 2 receptor (Amhr2), transcript variant 2, mRNA. / Q16671* / anti-Mullerian hormone receptor type 2*ENSMUSG0000002304725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000472  Activin types I and II receptor domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003605  GS domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development ISO
 biological_processGO:0001502 cartilage condensation IMP
 biological_processGO:0001550 ovarian cumulus expansion IMP
 biological_processGO:0001654 eye development IMP
 biological_processGO:0002062 chondrocyte differentiation IMP
 biological_processGO:0002063 chondrocyte development ISS
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006703 estrogen biosynthetic process NAS
 biological_processGO:0006954 inflammatory response IEP
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IGI
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0009953 dorsal/ventral pattern formation IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030166 proteoglycan biosynthetic process ISS
 biological_processGO:0030501 positive regulation of bone mineralization ISO
 biological_processGO:0030509 BMP signaling pathway IDA
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0032332 positive regulation of chondrocyte differentiation ISS
 biological_processGO:0035108 limb morphogenesis ISO
 biological_processGO:0042698 ovulation cycle IMP
 biological_processGO:0043010 camera-type eye development IGI
 biological_processGO:0045597 positive regulation of cell differentiation ISO
 biological_processGO:0045669 positive regulation of osteoblast differentiation ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060350 endochondral bone morphogenesis ISS
 biological_processGO:0061036 positive regulation of cartilage development ISS
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071773 cellular response to BMP stimulus ISO
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
 biological_processGO:1902731 negative regulation of chondrocyte proliferation ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity ISO
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005024 transforming growth factor beta-activated receptor activity TAS
 molecular_functionGO:0005025 transforming growth factor beta receptor activity, type I IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046332 SMAD binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Gdf5bp-J/Gdf5+
Genetic Background: involves: A/J

 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
Show

Allelic Composition: Bmp7tm1Rob/Bmp7tm1Rob,Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym,Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J * C57BL/6 * SJL

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym
Genetic Background: involves: C57BL/6 * SJL

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000552 abnormal radius morphology "malformation of the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml,Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: 129S/SvEv * A/J * C57BL/6J

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
Show

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1b+,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S/SvEv

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
Show

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1b+,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S/SvEv

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1b+,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S/SvEv

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jak2tm1Jni/Jak2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Bmpr1bTn(sb-lacZ,GFP)IR3.1Jtak/Bmpr1bTn(sb-lacZ,GFP)IR3.1Jtak
Genetic Background: involves: C3H * C57BL/6 * DBA/2 * ICR

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmpr1btm1Kml/Bmpr1b+,Gdf5bp-J/Gdf5+
Genetic Background: involves: 129S/SvEv * A/J * C57BL/6J

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Procrtm1Cte/Procrtm1Cte,Tg(F3)1Nmk/0
Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym,Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J * C57BL/6 * SJL

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jak2tm1Jni/Jak2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym
Genetic Background: involves: C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym
Genetic Background: involves: C57BL/6 * SJL

 MP:0002543 brachyphalangia "abnormally short phalanges" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Bmp7tm1Rob/Bmp7tm1Rob,Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym
Genetic Background: involves: C57BL/6 * SJL

 MP:0002657 chondrodystrophy "abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003072 abnormal metatarsal bone morphology "anomaly in the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym,Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J * C57BL/6 * SJL

 MP:0003073 abnormal metacarpal bone morphology "anomaly in the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym,Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J * C57BL/6 * SJL

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Bmp7tm1Rob/Bmp7tm1Rob,Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Bmp7tm1Rob/Bmp7tm1Rob,Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Bmp7tm1Rob/Bmp7tm1Rob,Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004634 short metacarpal bones "reduced length of the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml,Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: 129S/SvEv * A/J * C57BL/6J

Allelic Composition: Bmp7tm1Rob/Bmp7tm1Rob,Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004635 short metatarsal bones "reduced length of the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004639 fused metacarpal bones "improper union of one or more of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml,Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: 129S/SvEv * A/J * C57BL/6J

 MP:0004642 fused metatarsal bones "improper union of the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml,Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: 129S/SvEv * A/J * C57BL/6J

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005108 abnormal ulna morphology "malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1b+,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S/SvEv

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp7tm1Rob/Bmp7tm1Rob,Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Bmpr1btm1Kml/Bmpr1b+,Gdf5bp-J/Gdf5+
Genetic Background: involves: 129S/SvEv * A/J * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym
Genetic Background: involves: C57BL/6 * SJL

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1b+,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S/SvEv

 MP:0008258 thin endometrium "reduced thickness of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008275 failure of endochondral bone ossification "failure to initiate or a block in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008730 fused phalanges "anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0009097 absent endometrial glands "absence of the simple or branched tubular uterine glands" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0009250 abnormal appendicular skeleton morphology "any structural anomaly of the bones of the limbs, shoulder and pelvic girdles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Bmpr1bTn(sb-lacZ,GFP)IR3.1Jtak/Bmpr1bTn(sb-lacZ,GFP)IR3.1Jtak
Genetic Background: involves: C3H * C57BL/6 * DBA/2 * ICR

 MP:0009374 failure of cumulus expansion "complete inability of the cumulus cells to secrete an extensive extracellular matrix required for successful fertilization" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0009728 abnormal calcaneum morphology "any structural anomaly of the largest quadrangular bone at the back of the tarsus; it forms the heel or hock and articulates with the talus above it" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0012281 decreased sternebra size "reduced average size of any of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:anna]
Show

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0013400 abnormal endometrial gland development "aberrant formation or incomplete differentiation of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:Anna, PMID:23619340]
Show

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0014105 abnormal chondrocyte differentiation "any anomaly in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
Show

Allelic Composition: Bmpr1btm1Kml/Bmpr1btm1Kml
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Gmcl1Gt(OST6847)Lex/Gmcl1Gt(OST6847)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Bmpr1atm1Bhr/Bmpr1atm2.1Bhr,Bmpr1btm1Kml/Bmpr1btm1Kml,Tg(Six3-cre)69Frty/0
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021706 Q80U44 / Zfyve16 / zinc finger, FYVE domain containing 16 / Q7Z3T8* / zinc finger FYVE-type containing 16*  / complex / reaction
 ENSMUSG00000027358 Bmp2 / P21274 / Bone morphotic protein 2 / P12643* / bone morphogenetic protein 2*  / complex / reaction
 ENSMUSG00000025880 Smad7 / O35253 / SMAD family member 7 / O15105*  / complex / reaction
 ENSMUSG00000061393 Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*  / complex / reaction
 ENSMUSG00000027796 Smad9 / Q9JIW5 / Mothers against decapentaplegic homolog 9 / O15198* / SMAD family member 9*  / complex / reaction
 ENSMUSG00000036867 Smad6 / O35182 / Mothers against decapentaplegic homolog 6 / O43541* / SMAD family member 6*  / complex / reaction
 ENSMUSG00000052430 Bmpr1b / P36898 / Mus musculus bone morphotic protein receptor, type 1B (Bmpr1b), transcript variant 6, mRNA. / O00238* / bone morphogenetic protein receptor type 1B*  / complex
 ENSMUSG00000031681 Smad1 / P70340 / SMAD family member 1 / Q15797*  / complex / reaction
 ENSMUSG00000052155 Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*  / complex / reaction
 ENSMUSG00000021540 Smad5 / P97454 / Mothers against decapentaplegic homolog 5 / Q99717* / SMAD family member 5*  / complex / reaction
 ENSMUSG00000021796 Bmpr1a / P36895 / Bone morphotic protein receptor type-1A / P36894* / bone morphogenetic protein receptor type 1A*  / complex / reaction
 ENSMUSG00000018363 A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*  / complex / reaction
 ENSMUSG00000067336 Bmpr2 / O35607 / Bone morphotic protein receptor type-2 / Q13873* / bone morphogenetic protein receptor type 2*  / complex / reaction
 ENSMUSG00000038780 Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr