Manteia

ENSMUSG00000052459

Mus musculus

Features

Gene ID:	ENSMUSG00000052459

Biological name :	Atp6v1a

Synonyms :	Atp6v1a / Mus musculus ATPase, H+ transporting, lysosomal V1 subunit A (Atp6v1a), transcript variant 2, mRNA. / P50516

Possible biological names infered from orthology :	ATPase H+ transporting V1 subunit A / P38606

Species:	Mus musculus

Chr. number:	16
Strand:	-1
Band:	B4
Gene start:	44085402
Gene end:	44139705

Corresponding Affymetrix probe sets:	10439566 (MoGene1.0st) 1422508_at (Mouse Genome 430 2.0 Array) 1450634_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000118726 Ensembl peptide - ENSMUSP00000110314 Ensembl peptide - ENSMUSP00000116923 Ensembl peptide - ENSMUSP00000118429 Ensembl peptide - ENSMUSP00000066886 NCBI entrez gene - 11964 See in Manteia. MGI - MGI:1201780 RefSeq - XM_011245809 RefSeq - NM_001358203 RefSeq - NM_001358204 RefSeq - NM_007508 RefSeq - XM_006521720 RefSeq - XM_006521721 RefSeq Peptide - NP_031534 RefSeq Peptide - NP_001345133 RefSeq Peptide - NP_001345132 swissprot - D3YWH3 swissprot - D3YZ23 swissprot - D3Z1B9 swissprot - P50516 Ensembl - ENSMUSG00000052459

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR000194	ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
IPR004100	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
IPR005725	ATPase, V1 complex, subunit A
IPR020003	ATPase, alpha/beta subunit, nucleotide-binding domain, active site
IPR022878	V-type ATP synthase catalytic alpha chain
IPR024034	ATPase, F1/V1 complex, beta/alpha subunit, C-terminal
IPR027417	P-loop containing nucleoside triphosphate hydrolase
IPR031686	ATPsynthase alpha/beta subunit, N-terminal extension
IPR036121	ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0006879	cellular iron ion homeostasis	ISO
biological_process	GO:0015991	ATP hydrolysis coupled proton transport	IEA
biological_process	GO:0036295	cellular response to increased oxygen levels	ISO
biological_process	GO:0046034	ATP metabolic process	IEA
cellular_component	GO:0005739	mitochondrion	IDA
cellular_component	GO:0005765	lysosomal membrane	IBA
cellular_component	GO:0005829	cytosol	IDA
cellular_component	GO:0005886	plasma membrane	IDA
cellular_component	GO:0005902	microvillus	IDA
cellular_component	GO:0016324	apical plasma membrane	IDA
cellular_component	GO:0033180	proton-transporting V-type ATPase, V1 domain	IEA
cellular_component	GO:0043209	myelin sheath	IDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	IBA

Pathways (from Reactome)

Pathway description

ROS, RNS production in phagocytes

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000052459	P50516 / Atp6v1a / Mus musculus ATPase, H+ transporting, lysosomal V1 subunit A (Atp6v1a), transcript variant 2, mRNA. / P38606* / ATPase H+ transporting V1 subunit A*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr