ENSMUSG00000052520


Mus musculus

Features
Gene ID: ENSMUSG00000052520
  
Biological name :Cyp2j5
  
Synonyms : Cyp2j5 / Cytochrome P450 2J5 / O54749
  
Possible biological names infered from orthology : CYP2J2 / cytochrome P450 family 2 subfamily J member 2 / P51589
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C5
Gene start: 96628773
Gene end: 96664154
  
Corresponding Affymetrix probe sets: 10514532 (MoGene1.0st)   1417531_at (Mouse Genome 430 2.0 Array)   1417532_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030299
NCBI entrez gene - 13109     See in Manteia.
MGI - MGI:1270149
RefSeq - XM_006502720
RefSeq - NM_010007
RefSeq Peptide - NP_034137
swissprot - O54749
swissprot - Q3TNC5
Ensembl - ENSMUSG00000052520
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp2ad2ENSDARG00000021172Danio rerio
 cyp2ad3ENSDARG00000022650Danio rerio
 cyp2ad6ENSDARG00000042956Danio rerio
 cyp2ae1ENSDARG00000013524Danio rerio
 cyp2j20ENSDARG00000094057Danio rerio
 cyp2n13ENSDARG00000042953Danio rerio
 cyp2p10ENSDARG00000042990Danio rerio
 cyp2p6ENSDARG00000042978Danio rerio
 cyp2p7ENSDARG00000042980Danio rerio
 cyp2p8ENSDARG00000042982Danio rerio
 cyp2p9ENSDARG00000022631Danio rerio
 cyp2v1ENSDARG00000018485Danio rerio
 FO904880.1ENSDARG00000110366Danio rerio
 ENSGALG00000011413Gallus gallus
 CYP2J23ENSGALG00000011394Gallus gallus
 CYP2J2ENSG00000134716Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp2j6 / O54750 / Cytochrome P450 2J6 / P51589* / CYP2J2* / cytochrome P450 family 2 subfamily J member 2*ENSMUSG0000005291473
Cyp2j9 / cytochrome P450, family 2, subfamily j, polypeptide 9 / CYP2J2* / P51589* / cytochrome P450 family 2 subfamily J member 2*ENSMUSG0000001522471
Cyp2j13 / cytochrome P450, family 2, subfamily j, polypeptide 13 / CYP2J2* / P51589* / cytochrome P450 family 2 subfamily J member 2*ENSMUSG0000002857170
Cyp2j12 / cytochrome P450, family 2, subfamily j, polypeptide 12 / CYP2J2* / P51589* / cytochrome P450 family 2 subfamily J member 2*ENSMUSG0000008122569
Cyp2j8 / cytochrome P450, family 2, subfamily j, polypeptide 8 / CYP2J2* / P51589* / cytochrome P450 family 2 subfamily J member 2*ENSMUSG0000008293268
Cyp2j7 / cytochrome P450, family 2, subfamily j, polypeptide 7 / CYP2J2* / P51589* / cytochrome P450 family 2 subfamily J member 2*ENSMUSG0000008136267
Cyp2j11 / cytochrome P450, family 2, subfamily j, polypeptide 11 / CYP2J2* / P51589* / cytochrome P450 family 2 subfamily J member 2*ENSMUSG0000006609766
Cyp2r1 / Q6VVW9 / Vitamin D 25-hydroxylase / Q6VVX0* / cytochrome P450 family 2 subfamily R member 1*ENSMUSG0000003067041
Cyp2d26 / CYP2D6* / CYP2D7* / P10635* / A0A087X1C5* / cytochrome P450 family 2 subfamily D member 6* / cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)*ENSMUSG0000002244540
Cyp2u1 / Q9CX98 / Cytochrome P450 2U1 / Q7Z449* / cytochrome P450 family 2 subfamily U member 1*ENSMUSG0000002798339
Cyp2d34 / cytochrome P450, family 2, subfamily d, polypeptide 34 / CYP2D6* / CYP2D7* / P10635* / A0A087X1C5* / cytochrome P450 family 2 subfamily D member 6* / cytochrome P450 family 2 subf...ENSMUSG0000009455939
P24456 / Cyp2d10 / Cytochrome P450 2D10 / CYP2D7* / CYP2D6* / P10635* / A0A087X1C5* / cytochrome P450 family 2 subfamily D member 6* / cytochrome P450 family 2 subfamily D member 7 (gene/p...ENSMUSG0000009480639
P24457 / Cyp2d11 / Cytochrome P450 2D11 / CYP2D7* / CYP2D6* / P10635* / A0A087X1C5* / cytochrome P450 family 2 subfamily D member 6* / cytochrome P450 family 2 subfamily D member 7 (gene/p...ENSMUSG0000006808538
Cyp2d9 / P11714 / Cytochrome P450 2D9 / CYP2D6* / P10635* / CYP2D7* / A0A087X1C5* / cytochrome P450 family 2 subfamily D member 6* / cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)*ENSMUSG0000006808638
Cyp2d12 / cytochrome P450, family 2, subfamily d, polypeptide 12 / CYP2D6* / CYP2D7* / P10635* / A0A087X1C5* / cytochrome P450 family 2 subfamily D member 6* / cytochrome P450 family 2 subf...ENSMUSG0000009685238
Cyp2d22 / cytochrome P450, family 2, subfamily d, polypeptide 22 / CYP2D6* / CYP2D7* / P10635* / A0A087X1C5* / cytochrome P450 family 2 subfamily D member 6* / cytochrome P450 family 2 subf...ENSMUSG0000006174037
Cyp2w1 / E9Q816 / Cytochrome P450 2W1 / Q8TAV3* / cytochrome P450 family 2 subfamily W member 1*ENSMUSG0000002954132
Cyp2d40 / cytochrome P450, family 2, subfamily d, polypeptide 40 / CYP2D6* / CYP2D7* / P10635* / A0A087X1C5* / cytochrome P450 family 2 subfamily D member 6* / cytochrome P450 family 2 subf...ENSMUSG0000006808328


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR008071  Cytochrome P450, E-class, group I, CYP2J-like
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001990 regulation of systemic arterial blood pressure by hormone IMP
 biological_processGO:0001998 angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0097254 renal tubular secretion IMP
 biological_processGO:2000863 positive regulation of estrogen secretion IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070330 aromatase activity IEA


Pathways (from Reactome)
Pathway description
Fatty acids
Xenobiotics
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sh2d1b1tm2Vei/Sh2d1b1tm2Vei,Sh2d1b2tm1Vei/Sh2d1b2tm1Vei
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Sh2d1b1tm2Vei/Sh2d1b1tm2Vei,Sh2d1b2tm1Vei/Sh2d1b2tm1Vei
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003371 decreased circulating estrogen level "reduction in the blood concentration of any substance that causes development of the female reproductive organs and secondary sexual characteristics" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Sh2d1b1tm2Vei/Sh2d1b1tm2Vei,Sh2d1b2tm1Vei/Sh2d1b2tm1Vei
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Sh2d1b1tm2Vei/Sh2d1b1tm2Vei,Sh2d1b2tm1Vei/Sh2d1b2tm1Vei
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sh2d1b1tm2Vei/Sh2d1b1tm2Vei,Sh2d1b2tm1Vei/Sh2d1b2tm1Vei
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011417 abnormal renal transport "any anomaly of the directed movement of substances through the kidney" [MGI:csmith]
Show

Allelic Composition: Sh2d1b1tm2Vei/Sh2d1b1tm2Vei,Sh2d1b2tm1Vei/Sh2d1b2tm1Vei
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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