ENSMUSG00000054321


Mus musculus

Features
Gene ID: ENSMUSG00000054321
  
Biological name :Taf4b
  
Synonyms : G5E8Z2 / Taf4b / Transcription initiation factor TFIID subunit 4B
  
Possible biological names infered from orthology : Q92750 / TATA-box binding protein associated factor 4b
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A1
Gene start: 14783245
Gene end: 14900359
  
Corresponding Affymetrix probe sets: 10454077 (MoGene1.0st)   1431193_at (Mouse Genome 430 2.0 Array)   1435302_at (Mouse Genome 430 2.0 Array)   1435303_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126909
NCBI entrez gene - 72504     See in Manteia.
MGI - MGI:2152345
RefSeq - XM_006526282
RefSeq - NM_001100449
RefSeq - XM_006526281
RefSeq Peptide - NP_001093919
swissprot - G5E8Z2
Ensembl - ENSMUSG00000054321
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 taf4bENSDARG00000075732Danio rerio
 TAF4BENSGALG00000015122Gallus gallus
 TAF4BENSG00000141384Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Taf4 / TATA-box binding protein associated factor 4 / O00268*ENSMUSG0000003911735


Protein motifs (from Interpro)
Interpro ID Name
 IPR003894  TAFH/NHR1
 IPR007900  Transcription initiation factor TFIID component TAF4
 IPR009072  Histone-fold
 IPR037249  TAFH/NHR1 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006352 DNA-templated transcription, initiation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0048477 oogenesis IEA
 biological_processGO:0051123 RNA polymerase II transcriptional preinitiation complex assembly IEA
 biological_processGO:2000648 positive regulation of stem cell proliferation IMP
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex TAS
 cellular_componentGO:0005669 transcription factor TFIID complex IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly IBA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IBA
 molecular_functionGO:0008134 transcription factor binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051059 NF-kappaB binding ISO


Pathways (from Reactome)
Pathway description
RNA Polymerase II Pre-transcription Events
Regulation of TP53 Activity through Phosphorylation
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0001132 absent mature ovarian follicles "failure of ovarian follicle differentiation" [J:35782]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: BKSW.129S6-Spp1tm1Blh

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
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Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: BKSW.129S6-Spp1tm1Blh

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: BKSW.129S6-Spp1tm1Blh

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: BKSW.129S6-Spp1tm1Blh

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: BKSW.129S6-Spp1tm1Blh

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: BKSW.129S6-Spp1tm1Blh

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: BKSW.129S6-Spp1tm1Blh

 MP:0002685 abnormal proliferation of spermatogonia "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271]
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Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: BKSW.129S6-Spp1tm1Blh

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: BKSW.129S6-Spp1tm1Blh

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: BKSW.129S6-Spp1tm1Blh

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: BKSW.129S6-Spp1tm1Blh

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: BKSW.129S6-Spp1tm1Blh

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spp1tm1Blh/Spp1+
Genetic Background: BKSW.129S6-Spp1tm1Blh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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