ENSMUSG00000054594


Mus musculus

Features
Gene ID: ENSMUSG00000054594
  
Biological name :Oscar
  
Synonyms : Oscar / Osteoclast-associated immunoglobulin-like receptor / Q8VBT3
  
Possible biological names infered from orthology : Q8IYS5
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A1
Gene start: 3609813
Gene end: 3616157
  
Corresponding Affymetrix probe sets: 10559399 (MoGene1.0st)   1425442_at (Mouse Genome 430 2.0 Array)   1451710_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123672
Ensembl peptide - ENSMUSP00000041306
Ensembl peptide - ENSMUSP00000104285
NCBI entrez gene - 232790     See in Manteia.
MGI - MGI:2179720
RefSeq - NM_001290377
RefSeq - NM_175632
RefSeq Peptide - NP_001277306
RefSeq Peptide - NP_783440
swissprot - D3YXX9
swissprot - Q8VBT3
Ensembl - ENSMUSG00000054594
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IGSF1L3ENSGALG00000030005Gallus gallus
 OSCARENSG00000170909Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tarm1 / B6A8R8 / T-cell-interacting, activating receptor on myeloid cells protein 1 / B6A8C7* / T cell-interacting, activating receptor on myeloid cells 1*ENSMUSG0000005333831
Igsf1 / Q7TQA1 / Immunoglobulin superfamily member 1 / Q8N6C5*ENSMUSG0000003111124
A1bg / Q19LI2 / alpha-1-B glycoprotein / P04217*ENSMUSG0000002234721


Protein motifs (from Interpro)
Interpro ID Name
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mecomtm2.1Aspe/Mecomtm2.1Aspe,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * CBA

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecomtm2.1Aspe/Mecomtm2.1Aspe,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * CBA

Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oscartm1Ywc/Oscartm1Ywc,Tyrobptm1Ttk/Tyrobptm1Ttk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021795 Sftpd / P50404 / Pulmonary surfactant-associated protein D / P35247* / surfactant protein D*  / complex / reaction






 

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