ENSMUSG00000057228


Mus musculus

Features
Gene ID: ENSMUSG00000057228
  
Biological name :Aadat
  
Synonyms : Aadat / aminoadipate aminotransferase / Q9WVM8
  
Possible biological names infered from orthology : Q8N5Z0
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.1
Gene start: 60505932
Gene end: 60545677
  
Corresponding Affymetrix probe sets: 10571891 (MoGene1.0st)   1418519_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078436
Ensembl peptide - ENSMUSP00000148060
NCBI entrez gene - 23923     See in Manteia.
MGI - MGI:1345167
RefSeq - XM_006509397
RefSeq - NM_011834
RefSeq Peptide - NP_035964
swissprot - Q3UNS8
swissprot - Q9WVM8
Ensembl - ENSMUSG00000057228
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aadatENSDARG00000011410Danio rerio
 AADATENSGALG00000009655Gallus gallus
 AADATENSG00000109576Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004839  Aminotransferase, class I/classII
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006103 2-oxoglutarate metabolic process IEA
 biological_processGO:0006536 glutamate metabolic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0019441 tryptophan catabolic process to kynurenine IEA
 biological_processGO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine IEA
 biological_processGO:0070189 kynurenine metabolic process IEA
 biological_processGO:0097052 L-kynurenine metabolic process IEA
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0008483 transaminase activity IEA
 molecular_functionGO:0016212 kynurenine-oxoglutarate transaminase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0047536 2-aminoadipate transaminase activity ISO


Pathways (from Reactome)
Pathway description
Lysine catabolism
Tryptophan catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002862 altered righting response "altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003153 early eyelid opening "early average time for the first postnatal eye opening" [J:92240, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057228 Aadat / Q9WVM8 / aminoadipate aminotransferase / Q8N5Z0*  / complex






 

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