ENSMUSG00000060187


Mus musculus

Features
Gene ID: ENSMUSG00000060187
  
Biological name :Lrrc10
  
Synonyms : Leucine-rich repeat-containing protein 10 / Lrrc10 / Q8K3W2
  
Possible biological names infered from orthology : leucine rich repeat containing 10 / Q5BKY1
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D2
Gene start: 117045341
Gene end: 117046768
  
Corresponding Affymetrix probe sets: 10366541 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000073502
NCBI entrez gene - 237560     See in Manteia.
MGI - MGI:2448063
RefSeq - NM_146242
RefSeq Peptide - NP_666354
swissprot - Q8K3W2
Ensembl - ENSMUSG00000060187
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrc10ENSDARG00000045612Danio rerio
 LRRC10ENSGALG00000009976Gallus gallus
 LRRC10ENSG00000198812Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrrc10b / leucine rich repeat containing 10B / A6NIK2*ENSMUSG0000009029138
Mfhas1 / Q3V1N1 / Malignant fibrous histiocytoma-amplified sequence 1 homolog / Q9Y4C4* / malignant fibrous histiocytoma amplified sequence 1*ENSMUSG0000007005633
Scrib / Q80U72 / scribbled planar cell polarity protein / Q14160*ENSMUSG0000002256829
Lrrc7 / leucine rich repeat containing 7 / Q96NW7*ENSMUSG0000002817625
Lrrc1 / Q80VQ1 / Leucine-rich repeat-containing protein 1 / Q9BTT6* / leucine rich repeat containing 1*ENSMUSG0000003235225
Erbin / Q80TH2 / Q96RT1* / erbb2 interacting protein*ENSMUSG0000002170924
Lrrd1 / Q8C0R9 / Leucine-rich repeat and death domain-containing protein 1 / A4D1F6* / leucine rich repeats and death domain containing 1*ENSMUSG0000004036724
A6H6A4 / Lrriq4 / Leucine-rich repeat and IQ domain-containing protein 4 / A6NIV6* / leucine rich repeats and IQ motif containing 4*ENSMUSG0000002770322
Shoc2 / O88520 / Mus musculus soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), transcript variant 3, mRNA. / Q9UQ13* / SHOC2, leucine rich repeat scaffold protein*ENSMUSG0000002497621
Lrrc40 / leucine-rich repeat-containing protein 40 isoform b / Q9H9A6* / leucine rich repeat containing 40*ENSMUSG0000006305219
Lrrc30 / leucine rich repeat containing 30 / A6NM36*ENSMUSG0000007337515


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055013 cardiac muscle cell development IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0030016 myofibril IDA
 cellular_componentGO:0030017 sarcomere IDA
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0051393 alpha-actinin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Col4a1tm1.1Ics/Col4a1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Col4a1tm1.1Ics/Col4a1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col4a1tm1.1Ics/Col4a1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col4a1tm1.1Ics/Col4a1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Col4a1tm1.1Ics/Col4a1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col4a1tm1.1Ics/Col4a1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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