ENSMUSG00000063558


Mus musculus
bindingAox1dehydrogenasealdehydeoxidasesuperfamilyactivityxanthinefe-sdomainmolybdopterinfad-bindingbtypeoxidoreductasehammerheadiron-sulfur-bindingcoflavoproteinc-terminalsiteprocesselectronironionproteinclusterferredoxin-typeferredoxin

Features
Gene ID: ENSMUSG00000063558
  
Biological name :Aox1
  
Synonyms : aldehyde oxidase 1 / Aox1
  
Possible biological names infered from orthology : Q06278
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C1.3
Gene start: 58029931
Gene end: 58106413
  
Corresponding Affymetrix probe sets: 10346374 (MoGene1.0st)   1419435_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001027
NCBI entrez gene - 11761     See in Manteia.
MGI - MGI:88035
RefSeq - NM_009676
RefSeq Peptide - NP_033806
swissprot - G3X8P9
Ensembl - ENSMUSG00000063558
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aox6ENSDARG00000020054Danio rerio
 AOX1ENSG00000138356Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aox2 / Q5SGK3 / Aldehyde oxidase 2 ENSMUSG0000007955462
Aox3 / G3X982 / Aldehyde oxidase 3 ENSMUSG0000006429461
Aox4 / Q3TYQ9 / Aldehyde oxidase 4 ENSMUSG0000003824259
Xdh / Q00519 / xanthine dehydrogenase / P47989*ENSMUSG0000002406650


Protein motifs (from Interpro)
Interpro ID Name
 IPR000674  Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
 IPR001041  2Fe-2S ferredoxin-type iron-sulfur binding domain
 IPR002346  Molybdopterin dehydrogenase, FAD-binding
 IPR002888  [2Fe-2S]-binding
 IPR005107  CO dehydrogenase flavoprotein, C-terminal
 IPR006058  2Fe-2S ferredoxin, iron-sulphur binding site
 IPR008274  Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
 IPR012675  Beta-grasp domain superfamily
 IPR014313  Aldehyde oxidase
 IPR016166  FAD-binding, type 2
 IPR016167  FAD-binding, type 2, subdomain 1
 IPR016208  Aldehyde oxidase/xanthine dehydrogenase
 IPR022407  Oxidoreductase, molybdopterin binding site
 IPR036010  2Fe-2S ferredoxin-like superfamily
 IPR036318  FAD-binding, type 2-like superfamily
 IPR036683  CO dehydrogenase flavoprotein, C-terminal domain superfamily
 IPR036856  Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily
 IPR036884  [2Fe-2S]-binding domain superfamily
 IPR037165  Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily


Gene Ontology (GO)
cellular metabolic processoxidation-reduction processcellular metabolic processoxidation-reduction processcellular metabolic processoxidation-reduction processcellular metabolic processoxidation-reduction processcellular metabolic processoxidation-reduction processcellular metabolic processoxidation-reduction processcellular metabolic processoxidation-reduction processcellular metabolic processoxidation-reduction processcellular metabolic processoxidation-reduction processcellular metabolic processoxidation-reduction processcellular metabolic processcellular metabolic processoxidation-reduction processoxidation-reduction process
oxidoreductase activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingmetal cluster bindingoxidoreductase activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingmetal cluster bindingoxidoreductase activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingmetal cluster bindingoxidoreductase activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingmetal cluster bindingoxidoreductase activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingmetal cluster bindingoxidoreductase activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingmetal cluster bindingoxidoreductase activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingmetal cluster bindingoxidoreductase activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingmetal cluster bindingoxidoreductase activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingmetal cluster bindingoxidoreductase activityion bindingprotein bindingorganic cyclic compound bindingheterocyclic compound bindingcofactor bindingsmall molecule bindingmetal cluster bindingoxidoreductase acoxidoreductase activityion bindingion bindingprotein bindingprotein bindingorganic cyclic coorganic cyclic compound bindingheterocyclic compheterocyclic compound bindingcofactor bindingcofactor bindingsmall molecule bismall molecule bindingmetal cluster binmetal cluster binding
cellcellcellcellcellcellcellcellcellcellcellcell
TypeGO IDTermEv.Code
 biological_processGO:0017144 drug metabolic process IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004031 aldehyde oxidase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016614 oxidoreductase activity, acting on CH-OH group of donors IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043546 molybdopterin cofactor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0051287 NAD binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051537 2 iron, 2 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Vitamins B6 activation to pyridoxal phosphate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000063558 Aox1 / aldehyde oxidase 1 / Q06278*  / complex






 

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