ENSMUSG00000066684


Mus musculus

Features
Gene ID: ENSMUSG00000066684
  
Biological name :Pilrb1
  
Synonyms : Paired immunoglobulin-like type 2 receptor beta / Pilrb1 / Q2YFS2
  
Possible biological names infered from orthology : paired immunoglobin like type 2 receptor alpha / paired immunoglobin-like type 2 receptor beta / PILRA / PILRB / Q9UKJ0 / Q9UKJ1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 137852147
Gene end: 137858106
  
Corresponding Affymetrix probe sets: 10534935 (MoGene1.0st)   1422041_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106606
Ensembl peptide - ENSMUSP00000143777
Ensembl peptide - ENSMUSP00000143379
Ensembl peptide - ENSMUSP00000142614
Ensembl peptide - ENSMUSP00000142422
NCBI entrez gene - 170741     See in Manteia.
MGI - MGI:2450532
RefSeq - XM_011240935
RefSeq - NM_133209
RefSeq - XM_011240933
RefSeq - XM_011240934
RefSeq Peptide - NP_573472
swissprot - B7ZWH4
swissprot - Q2YFS2
swissprot - A0A0G2JE34
swissprot - A0A0G2JDM1
swissprot - A0A0G2JH07
Ensembl - ENSMUSG00000066684
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PILRAENSG00000085514Homo sapiens
 PILRBENSG00000121716Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q2YFS1 / Pilrb2 / Paired immunoglobulin-like type 2 receptor beta-2 / PILRB* / PILRA* / Q9UKJ0* / Q9UKJ1* / paired immunoglobin-like type 2 receptor beta* / paired immunoglobin like type 2...ENSMUSG0000006668287
Pilra / Q2YFS3 / Paired immunoglobulin-like type 2 receptor alpha / PILRB* / Q9UKJ0* / Q9UKJ1* / paired immunoglobin-like type 2 receptor beta* / paired immunoglobin like type 2 receptor alpha*ENSMUSG0000004624570


Protein motifs (from Interpro)
Interpro ID Name
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001773 myeloid dendritic cell activation IDA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042288 MHC class I protein binding IDA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008642 decreased circulating interleukin-1 beta level "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030329 Pianp / Q6P1B3 / PILR alpha-associated neural protein / Q8IYJ0*  / complex / reaction
 ENSMUSG00000036103 Q8K4Q8 / Colec12 / Collectin-12 / Q5KU26* / collectin subfamily member 12*  / complex / reaction
 ENSMUSG00000074491 Clec4g / Q8BNX1 / C-type lectin domain family 4 member G / Q6UXB4*  / complex / reaction
 ENSMUSG00000015094 Npdc1 / Q64322 / Neural proliferation differentiation and control protein 1 / Q9NQX5* / neural proliferation, differentiation and control 1*  / complex / reaction






 

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