ENSMUSG00000074491


Mus musculus

Features
Gene ID: ENSMUSG00000074491
  
Biological name :Clec4g
  
Synonyms : Clec4g / C-type lectin domain family 4 member G / Q8BNX1
  
Possible biological names infered from orthology : Q6UXB4
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A1.1
Gene start: 3707064
Gene end: 3720651
  
Corresponding Affymetrix probe sets: 10576772 (MoGene1.0st)   10576774 (MoGene1.0st)   1427428_at (Mouse Genome 430 2.0 Array)   1431575_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059574
Ensembl peptide - ENSMUSP00000124493
Ensembl peptide - ENSMUSP00000136805
NCBI entrez gene - 75863     See in Manteia.
MGI - MGI:1923113
RefSeq - NM_029465
RefSeq Peptide - NP_083741
swissprot - F6T066
swissprot - Q8BNX1
swissprot - Q9D4Q9
Ensembl - ENSMUSG00000074491
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:174904ENSDARG00000059049Danio rerio
 CLEC4GENSG00000182566Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P20693 / Fcer2a / Low affinity immunoglobulin epsilon Fc receptor / FCER2* / P06734* / Fc fragment of IgE receptor II*ENSMUSG0000000554028
Clec4f / Q8N1N0* / C-type lectin domain family 4 member F*ENSMUSG0000001454224
Asgr2 / P24721 / Asialoglycoprotein receptor 2 / P07307*ENSMUSG0000004096324
Asgr1 / P34927 / Asialoglycoprotein receptor 1 / P07306*ENSMUSG0000002088423
Mgl2ENSMUSG0000004095023
P49300 / Clec10a / C-type lectin domain family 10 member A ENSMUSG0000000031822
Cd209f / CD209f antigenENSMUSG0000005190622
Cd207 / Q8VBX4 / C-type lectin domain family 4 member K / Q9UJ71* / CD207 molecule*ENSMUSG0000003478321
Cd209g / CD209g antigenENSMUSG0000007916821
Q91ZX1 / Cd209a / CD209 antigen-like protein A / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000003149420
Q91ZW8 / Cd209d / CD209 antigen-like protein D / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000003149520
Clec4e / Q9R0Q8 / C-type lectin domain family 4 member E / Q9ULY5*ENSMUSG0000003014219
Q91ZW9 / Cd209c / CD209 antigen-like protein C / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000004016519
Q8CJ91 / Cd209b / CD209 antigen-like protein B / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000006598719
Q91ZW7 / Cd209e / CD209 antigen-like protein E / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000004019718


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002710 negative regulation of T cell mediated immunity IMP
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0030247 polysaccharide binding IDA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crygstm1Gwis/Crygstm1Gwis
Genetic Background: B6.129-Crygstm1Gwis

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000046245 Pilra / Q2YFS3 / Paired immunoglobulin-like type 2 receptor alpha / PILRB* / Q9UKJ0* / Q9UKJ1* / paired immunoglobin-like type 2 receptor beta* / paired immunoglobin like type 2 receptor alpha*  / complex / reaction
 ENSMUSG00000066684 Q2YFS2 / Pilrb1 / Paired immunoglobulin-like type 2 receptor beta / PILRB* / PILRA* / Q9UKJ0* / Q9UKJ1* / paired immunoglobin-like type 2 receptor beta* / paired immunoglobin like type 2 r...  / complex / reaction
 ENSMUSG00000066682 Q2YFS1 / Pilrb2 / Paired immunoglobulin-like type 2 receptor beta-2 / PILRB* / PILRA* / Q9UKJ0* / Q9UKJ1* / paired immunoglobin-like type 2 receptor beta* / paired immunoglobin like type 2...  / complex / reaction






 

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