ENSMUSG00000034783


Mus musculus

Features
Gene ID: ENSMUSG00000034783
  
Biological name :Cd207
  
Synonyms : Cd207 / C-type lectin domain family 4 member K / Q8VBX4
  
Possible biological names infered from orthology : CD207 molecule / Q9UJ71
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C3
Gene start: 83671215
Gene end: 83677857
  
Corresponding Affymetrix probe sets: 10545742 (MoGene1.0st)   1425243_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040746
NCBI entrez gene - 246278     See in Manteia.
MGI - MGI:2180021
RefSeq - NM_144943
RefSeq - XM_006506139
RefSeq Peptide - NP_659192
swissprot - Q8VBX4
Ensembl - ENSMUSG00000034783
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD207ENSG00000116031Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clec4f / Q8N1N0* / C-type lectin domain family 4 member F*ENSMUSG0000001454232
P20693 / Fcer2a / Low affinity immunoglobulin epsilon Fc receptor / FCER2* / P06734* / Fc fragment of IgE receptor II*ENSMUSG0000000554019
P49300 / Clec10a / C-type lectin domain family 10 member A ENSMUSG0000000031818
Asgr1 / P34927 / Asialoglycoprotein receptor 1 / P07306*ENSMUSG0000002088418
Mgl2ENSMUSG0000004095018
Asgr2 / P24721 / Asialoglycoprotein receptor 2 / P07307*ENSMUSG0000004096318
Q8CJ91 / Cd209b / CD209 antigen-like protein B / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000006598718
Clec4g / Q8BNX1 / C-type lectin domain family 4 member G / Q6UXB4*ENSMUSG0000007449118
Clec4e / Q9R0Q8 / C-type lectin domain family 4 member E / Q9ULY5*ENSMUSG0000003014217
Q91ZW8 / Cd209d / CD209 antigen-like protein D / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000003149517
Cd209f / CD209f antigenENSMUSG0000005190617
Q91ZX1 / Cd209a / CD209 antigen-like protein A / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000003149416
Cd209g / CD209g antigenENSMUSG0000007916816
Q91ZW9 / Cd209c / CD209 antigen-like protein C / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000004016515
Q91ZW7 / Cd209e / CD209 antigen-like protein E / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000004019715


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033989  CD209-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0051607 defense response to virus IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0030246 carbohydrate binding ISO


Pathways (from Reactome)
Pathway description
Cross-presentation of soluble exogenous antigens (endosomes)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo5argsc432/Myo5argsc432
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0002534 type IV hypersensitivity reaction "an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Esco2tm1.2Ge/Esco2tm1.2Ge
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N * SJL

Allelic Composition: Cd207tm2.1(cre)Bjec/Cd207+,Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo5argsc432/Myo5argsc432
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0008117 abnormal Langerhans cell morphology "any structural anomaly of a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [CL:0000453, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkbiztm1Mamo/Nfkbiztm1Mamo
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

 MP:0008118 absent Langerhans cell "absence of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cd207tm1(DTR/EGFP)Bjec/Cd207+
Genetic Background: involves: C57BL/6 * SJL

 MP:0008119 decreased Langerhans cell number "reduction in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd207tm2Mal/Cd207tm3(DTR/GFP)Mal
Genetic Background: involves: 129S2/SvPas

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd207tm1(DTR/EGFP)Bjec/Cd207+
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Cd207tm2.1(cre)Bjec/Cd207+,Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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