ENSMUSG00000005540


Mus musculus

Features
Gene ID: ENSMUSG00000005540
  
Biological name :Fcer2a
  
Synonyms : Fcer2a / Low affinity immunoglobulin epsilon Fc receptor / P20693
  
Possible biological names infered from orthology : FCER2 / Fc fragment of IgE receptor II / P06734
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A1.1
Gene start: 3681737
Gene end: 3694175
  
Corresponding Affymetrix probe sets: 10576757 (MoGene1.0st)   1422122_at (Mouse Genome 430 2.0 Array)   1451713_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146822
Ensembl peptide - ENSMUSP00000146689
Ensembl peptide - ENSMUSP00000147052
Ensembl peptide - ENSMUSP00000005678
Ensembl peptide - ENSMUSP00000146380
Ensembl peptide - ENSMUSP00000146568
Ensembl peptide - ENSMUSP00000146647
NCBI entrez gene - 14128     See in Manteia.
MGI - MGI:95497
RefSeq - XM_006508697
RefSeq - NM_001253737
RefSeq - NM_001253739
RefSeq - NM_001253743
RefSeq - NM_001253745
RefSeq - NM_001253746
RefSeq - NM_001253747
RefSeq - NM_013517
RefSeq Peptide - NP_001240676
RefSeq Peptide - NP_038545
RefSeq Peptide - NP_001240668
RefSeq Peptide - NP_001240672
RefSeq Peptide - NP_001240674
RefSeq Peptide - NP_001240666
RefSeq Peptide - NP_001240675
swissprot - Q8VH33
swissprot - A0A140LJ27
swissprot - P20693
swissprot - Q8VH32
swissprot - A0A140LI63
Ensembl - ENSMUSG00000005540
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:174904ENSDARG00000059049Danio rerio
 FCER2ENSG00000104921Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clec4g / Q8BNX1 / C-type lectin domain family 4 member G / Q6UXB4*ENSMUSG0000007449124
P49300 / Clec10a / C-type lectin domain family 10 member A ENSMUSG0000000031821
Clec4f / Q8N1N0* / C-type lectin domain family 4 member F*ENSMUSG0000001454221
Mgl2ENSMUSG0000004095021
Asgr2 / P24721 / Asialoglycoprotein receptor 2 / P07307*ENSMUSG0000004096321
Cd209f / CD209f antigenENSMUSG0000005190621
Asgr1 / P34927 / Asialoglycoprotein receptor 1 / P07306*ENSMUSG0000002088420
Cd207 / Q8VBX4 / C-type lectin domain family 4 member K / Q9UJ71* / CD207 molecule*ENSMUSG0000003478319
Cd209g / CD209g antigenENSMUSG0000007916819
Q91ZX1 / Cd209a / CD209 antigen-like protein A / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000003149418
Q91ZW8 / Cd209d / CD209 antigen-like protein D / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000003149518
Q91ZW7 / Cd209e / CD209 antigen-like protein E / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000004019718
Q8CJ91 / Cd209b / CD209 antigen-like protein B / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000006598718
Clec4e / Q9R0Q8 / C-type lectin domain family 4 member E / Q9ULY5*ENSMUSG0000003014217
Q91ZW9 / Cd209c / CD209 antigen-like protein C / CD209* / Q9NNX6* / CLEC4M* / Q9H2X3* / CD209 molecule* / C-type lectin domain family 4 member M*ENSMUSG0000004016517


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033989  CD209-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IMP
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity ISO
 biological_processGO:0051712 positive regulation of killing of cells of other organism ISO
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0019863 IgE binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001666 abnormal nutrient absorption "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cplx3tm1Rmnd/Cplx3tm1Rmnd,Cplx4tm1Bros/Cplx4tm1Bros
Genetic Background: involves: C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gcktm1.2Mgn/Gck+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gcktm1.2Mgn/Gck+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfr2tm1Dsn/Fgfr2tm1Dsn,Tg(KRT5-cre)5132Jlj/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gcktm1.2Mgn/Gck+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: B6.C(Cg)-Ighg1tm1.1Pyu

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcer2atm1Max/Fcer2atm1Max
Genetic Background: involves: C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1Adv/Trp53+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Fcer2atm1Putt/Fcer2a+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max
Genetic Background: involves: C57BL/6

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gcktm1.2Mgn/Gck+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005153 abnormal B cell proliferation "change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grin1tm1Cur/Grin1tm1.1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max
Genetic Background: involves: C57BL/6J

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max
Genetic Background: involves: C57BL/6

Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max
Genetic Background: involves: C57BL/6

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer2atm1Max/Fcer2atm1Max
Genetic Background: involves: C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer2atm1Max/Fcer2atm1Max
Genetic Background: involves: C57BL/6

 MP:0008897 decreased IgG2c level "less than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1tm1.1Pyu
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max,Ighg1tm1.1Pyu/Ighg1+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
Show

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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