ENSMUSG00000072423


Mus musculus

Features
Gene ID: ENSMUSG00000072423
  
Biological name :Psmb11
  
Synonyms : Proteasome subunit beta type-11 / Psmb11 / Q8BG41
  
Possible biological names infered from orthology : A5LHX3 / proteasome subunit beta 11
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C2
Gene start: 54621433
Gene end: 54629556
  
Corresponding Affymetrix probe sets: 10415086 (MoGene1.0st)   1453150_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132140
Ensembl peptide - ENSMUSP00000154313
NCBI entrez gene - 73902     See in Manteia.
MGI - MGI:1921152
RefSeq - NM_175204
RefSeq Peptide - NP_780413
swissprot - Q8BG41
Ensembl - ENSMUSG00000072423
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmb11aENSDARG00000108530Danio rerio
 psmb11bENSDARG00000068086Danio rerio
 A5LHX3ENSG00000222028Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Psmb5 / O55234 / Proteasome subunit beta type-5 / P28074* / proteasome subunit beta 5*ENSMUSG0000002219340
Psmb8 / P28063 / Proteasome subunit beta type-8 / P28062* / proteasome subunit beta 8*ENSMUSG0000002433839


Protein motifs (from Interpro)
Interpro ID Name
 IPR000243  Peptidase T1A, proteasome beta-subunit
 IPR001353  Proteasome, subunit alpha/beta
 IPR016050  Proteasome beta-type subunit, conserved site
 IPR023333  Proteasome B-type subunit
 IPR029055  Nucleophile aminohydrolases, N-terminal
 IPR034385  Proteasome subunit beta type 11


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0043374 CD8-positive, alpha-beta T cell differentiation IMP
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005839 proteasome core complex IDA
 cellular_componentGO:0019774 proteasome core complex, beta-subunit complex ISS
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004298 threonine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N

Allelic Composition: H2dlAb1-Ea/H2dlAb1-Ea,Psmb11tm1(Psmb8)Khog/Psmb11tm1(Psmb8)Khog
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005005 abnormal self tolerance "a defect in the normal lack of response to autologous (self) antigens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Vlcg/Gt(ROSA)26Sortm1(DTA)Vlcg,Tg(BGLAP-cre/ERT2)#Stko/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tctn1Gt(KST296)Byg/Tctn1Gt(KST296)Byg,Smotm1Amc/Smotm1Amc
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Psmb11tm1(Psmb8)Khog/Psmb11tm1(Psmb8)Khog
Genetic Background: involves: C57BL/6

Allelic Composition: H2dlAb1-Ea/H2dlAb1-Ea,Psmb11tm1(Psmb8)Khog/Psmb11tm1(Psmb8)Khog
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Psmb11tm1(Psmb8)Khog/Psmb11+
Genetic Background: involves: C57BL/6

Allelic Composition: Psmb11tm1.1(Psmb8)Khog/Psmb11tm1.1(Psmb8)Khog,Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac

Allelic Composition: Psmb11tm1(Psmb8)Khog/Psmb11tm1(Psmb8)Khog,Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008754 abnormal T cell receptor V(D)J recombination "any anomaly in the process by which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033153, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psmb11tm1(Psmb8)Khog/Psmb11tm1(Psmb8)Khog
Genetic Background: involves: C57BL/6

Allelic Composition: Psmb11tm1.1(Psmb8)Khog/Psmb11tm1.1(Psmb8)Khog,Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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