ENSDARG00000003699


Danio rerio

Features
Gene ID: ENSDARG00000003699
  
Biological name :atp7a
  
Synonyms : atp7a / ATPase copper transporting alpha
  
Possible biological names infered from orthology : Copper-transporting ATPase 1 / Q04656 / Q64430
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 22397251
Gene end: 22443502
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000145829
Ensembl peptide - ENSDARP00000054976
Ensembl peptide - ENSDARP00000111966
NCBI entrez gene - 564924     See in Manteia.
swissprot - F1Q5B3
swissprot - F1QEG1
ZFIN ID - ZDB-GENE-060825-45
Ensembl - ENSDARG00000003699
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATP7AENSGALG00000007902Gallus gallus
 ATP7AENSG00000165240Homo sapiens
 Atp7aENSMUSG00000033792Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
atp7b / ATPase copper transporting beta / P35670* / Q64446* / Copper-transporting ATPase 2 *ENSDARG0000005814549


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR006121  Heavy metal-associated domain, HMA
 IPR006122  Heavy metal-associated domain, copper ion-binding
 IPR008250  P-type ATPase, A domain superfamily
 IPR017969  Heavy-metal-associated, conserved site
 IPR018303  P-type ATPase, phosphorylation site
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR027256  P-type ATPase, subfamily IB


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0010038 response to metal ion IDA
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0046688 response to copper ion IMP
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019829 cation-transporting ATPase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ion influx/efflux at host-pathogen interface
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood quality , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary quality , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle increased size , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
Show

 ZFA:0000135 notochord notochord morphology , abnormal
notochord undulate , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium color , abnormal
Show

 ZFA:0000434 skeletal system skeletal system morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism morphology , abnormal
Show

 ZFA:0009091 melanocyte melanocyte intensity , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000087693 atox1 / antioxidant 1 copper chaperone / O00244* / O08997* / Copper transport protein ATOX1 *  / reaction
 ENSDARG00000053194 pdzd11 / Q6NXB2 / PDZ domain containing 11 / Q9CZG9* / Q5EBL8* / PDZ domain-containing protein 11 *  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr