ENSMUSG00000033792


Mus musculus

Features
Gene ID: ENSMUSG00000033792
  
Biological name :Atp7a
  
Synonyms : Atp7a / Copper-transporting ATPase 1 / Q64430
  
Possible biological names infered from orthology : ATPase copper transporting alpha / Q04656
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: D
Gene start: 106027276
Gene end: 106124926
  
Corresponding Affymetrix probe sets: 10601360 (MoGene1.0st)   1418774_a_at (Mouse Genome 430 2.0 Array)   1436921_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058840
Ensembl peptide - ENSMUSP00000109186
NCBI entrez gene - 11977     See in Manteia.
MGI - MGI:99400
RefSeq - NM_001109757
RefSeq - NM_009726
RefSeq Peptide - NP_001103227
RefSeq Peptide - NP_033856
swissprot - Q64430
swissprot - A2AG68
Ensembl - ENSMUSG00000033792
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp7aENSDARG00000003699Danio rerio
 ATP7AENSGALG00000007902Gallus gallus
 ATP7AENSG00000165240Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp7b / Q64446 / Copper-transporting ATPase 2 / P35670* / ATPase copper transporting beta*ENSMUSG0000000656754


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR006121  Heavy metal-associated domain, HMA
 IPR006122  Heavy metal-associated domain, copper ion-binding
 IPR008250  P-type ATPase, A domain superfamily
 IPR017969  Heavy-metal-associated, conserved site
 IPR018303  P-type ATPase, phosphorylation site
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR027256  P-type ATPase, subfamily IB
 IPR036163  Heavy metal-associated domain superfamily
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001836 release of cytochrome c from mitochondria IMP
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0002082 regulation of oxidative phosphorylation IMP
 biological_processGO:0006568 tryptophan metabolic process IMP
 biological_processGO:0006570 tyrosine metabolic process IMP
 biological_processGO:0006584 catecholamine metabolic process IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006825 copper ion transport ISO
 biological_processGO:0006878 cellular copper ion homeostasis ISO
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007595 lactation IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0010041 response to iron(III) ion IEA
 biological_processGO:0010042 response to manganese ion IEA
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0010273 detoxification of copper ion IMP
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010592 positive regulation of lamellipodium assembly IEA
 biological_processGO:0015677 copper ion import IMP
 biological_processGO:0015679 plasma membrane copper ion transport IEA
 biological_processGO:0018205 peptidyl-lysine modification IMP
 biological_processGO:0019430 removal of superoxide radicals IMP
 biological_processGO:0021702 cerebellar Purkinje cell differentiation IMP
 biological_processGO:0021860 pyramidal neuron development IMP
 biological_processGO:0021954 central nervous system neuron development IMP
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0031069 hair follicle morphogenesis IMP
 biological_processGO:0034760 negative regulation of iron ion transmembrane transport IEA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0042093 T-helper cell differentiation IMP
 biological_processGO:0042414 epinephrine metabolic process IMP
 biological_processGO:0042415 norepinephrine metabolic process IMP
 biological_processGO:0042417 dopamine metabolic process IMP
 biological_processGO:0042421 norepinephrine biosynthetic process IMP
 biological_processGO:0042428 serotonin metabolic process IMP
 biological_processGO:0043085 positive regulation of catalytic activity IMP
 biological_processGO:0043086 negative regulation of catalytic activity IMP
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0043588 skin development IMP
 biological_processGO:0045793 positive regulation of cell size IEA
 biological_processGO:0046034 ATP metabolic process IMP
 biological_processGO:0046688 response to copper ion IEA
 biological_processGO:0048251 elastic fiber assembly IMP
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0048812 neuron projection morphogenesis IMP
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0051353 positive regulation of oxidoreductase activity ISO
 biological_processGO:0051542 elastin biosynthetic process IMP
 biological_processGO:0060003 copper ion export IMP
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071236 cellular response to antibiotic IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071279 cellular response to cobalt ion IEA
 biological_processGO:0071280 cellular response to copper ion IEA
 biological_processGO:0071281 cellular response to iron ion IEA
 biological_processGO:0071284 cellular response to lead ion IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 biological_processGO:1903036 positive regulation of response to wounding IEA
 biological_processGO:1904754 positive regulation of vascular associated smooth muscle cell migration IEA
 biological_processGO:1904959 regulation of cytochrome-c oxidase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005770 late endosome ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0016323 basolateral plasma membrane ISO
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030140 trans-Golgi network transport vesicle ISS
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004008 copper-exporting ATPase activity IDA
 molecular_functionGO:0005375 copper ion transmembrane transporter activity IMP
 molecular_functionGO:0005507 copper ion binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016532 superoxide dismutase copper chaperone activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019829 cation-transporting ATPase activity IEA
 molecular_functionGO:0032767 copper-dependent protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:1903136 cuprous ion binding ISO


Pathways (from Reactome)
Pathway description
Ion influx/efflux at host-pathogen interface
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp7aMo-dp2/Atp7a+
Genetic Background: Not Specified

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Atp7aMo-dp/Y
Genetic Background: Not Specified

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp7aMo-blo/Atp7aMo-blo
Genetic Background: Not Specified

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-vbr/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7a+
Genetic Background: Not Specified

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp7aMo-blo/Atp7aMo-blo
Genetic Background: Not Specified

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-ms/Y
Genetic Background: involves: CBA

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7aMo-blo
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-pew/Y
Genetic Background: CBA/J-Atp7aMo-pew

Allelic Composition: Atp7aMo-pew2J/Y
Genetic Background: involves: C57BL/6J * SJL/J

Allelic Composition: Atp7aMo-8J/Y
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Atp7aMo-8J/Atp7a+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Atp7aMo-ms/Y
Genetic Background: Not Specified

 MP:0000372 irregular coat pigmentation "uneven coloration of the hair" [J:65030]
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Allelic Composition: Atp7aMo-pew/Atp7a+
Genetic Background: CBA/J-Atp7aMo-pew

Allelic Composition: Atp7aMo-pew2J/Atp7a+
Genetic Background: involves: C57BL/6J * SJL/J

Allelic Composition: Atp7aMo-8J/Atp7a+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000400 abnormal awl hair "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp7aMo-ms/Y
Genetic Background: involves: CBA/Kw

 MP:0000402 abnormal zigzag hairs "anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp7aMo-ms/Y
Genetic Background: involves: CBA/Kw

 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
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Allelic Composition: Atp7aMo-dp2/Atp7a+
Genetic Background: Not Specified

 MP:0000421 mottled coat "coat has spots, streaks, and/or blotches of a different color" [J:17194]
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Allelic Composition: Atp7aMo-Tohm/Y
Genetic Background: involves: AA * C3H/He * C57BL/6 * ICR

Allelic Composition: Atp7aMo-Tohm/Atp7a+
Genetic Background: B6.Cg-Atp7aMo-Tohm

Allelic Composition: Atp7aMo-4R/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-pew/Atp7a+
Genetic Background: CBA/J-Atp7aMo-pew

Allelic Composition: Atp7aMo-dp2/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Atp7aMo-9J/Atp7a+
Genetic Background: involves: C57BL/6J

Allelic Composition: Atp7aMo-pew2J/Atp7a+
Genetic Background: involves: C57BL/6J * SJL/J

Allelic Composition: Atp7aMo-18H/Atp7a+
Genetic Background: involves: 101/H

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7aMo-blo
Genetic Background: Not Specified

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp7aMo-dp2/Atp7a+
Genetic Background: Not Specified

 MP:0000576 clubbed feet "congenital deformation of the feet; foot is plantarflexed, inverted and adducted" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Atp7aMo-dp/Atp7a+
Genetic Background: Not Specified

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Atp7aMo-ms/Y
Genetic Background: Not Specified

 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp7aMo-ms/Y
Genetic Background: involves: CBA/Kw

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp7aMo-8J/Y
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Atp7aMo-8J/Atp7a+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Atp7aMo-ms/Y
Genetic Background: Not Specified

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Atp7aMo-Tohm/Atp7a+
Genetic Background: B6.Cg-Atp7aMo-Tohm

 MP:0000815 abnormal ammon gyrus morphology "malformations of one of the two interlocking gyri of the hippocampus; a circonvolution of rhinencephalon, the grey substance of which is rich in big pyramidal neuronal cells " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp7aMo-Tohm/Atp7a+
Genetic Background: B6.Cg-Atp7aMo-Tohm

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Atp7aMo-Tohm/Atp7a+
Genetic Background: B6.Cg-Atp7aMo-Tohm

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Atp7aMo-Tohm/Atp7a+
Genetic Background: B6.Cg-Atp7aMo-Tohm

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp7aMo-vbr/Y
Genetic Background: Not Specified

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Atp7aMo-ms/Atp7a+
Genetic Background: Not Specified

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Atp7aMo-7ENURF/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7aMo-blo
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-brJ/Atp7a+,Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ

 MP:0001274 curly vibrissae "whiskers twisted into coils or spirals" [J:47620]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atp7aMo-N/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-ca/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-10H/Y
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atp7aMo-12H/Atp7a+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7aMo-blo
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-dp/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-dp2/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-9J/Atp7a+
Genetic Background: involves: C57BL/6J

Allelic Composition: Atp7aMo-ms/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-ms/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-ms/Y
Genetic Background: involves: CBA/Kw

Allelic Composition: Atp7aMo-ml/Y
Genetic Background: C3Hf/He

Allelic Composition: Atp7aMo-18H/Atp7a+
Genetic Background: involves: 101/H

Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

Allelic Composition: Atp7aMo-dp/Atp7a+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0001278 kinked vibrissae "sharp bends in the vibrissae" [J:56641]
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Allelic Composition: Atp7aMo-4R/Y
Genetic Background: Not Specified

 MP:0001279 wavy vibrissae "whiskers having undulations or a sinusoidal shape" [J:65044]
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Allelic Composition: Atp7aMo-8J/Y
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Atp7aMo-8J/Atp7a+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
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Allelic Composition: Notch3tm1.1(cre/ERT2)Sat/Notch3+
Genetic Background: C57BL/6-Notch3tm1.1(cre/ERT2)Sat

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Atp7aMo-ms/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-ml/Y
Genetic Background: C3Hf/He

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp7aMo-10H/Y
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atp7aMo-12H/Atp7a+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7a+
Genetic Background: Not Specified

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp7aMo-5J/Y
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Atp7aMo-dp2/Atp7a+
Genetic Background: Not Specified

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Atp7aMo-12H/Atp7a+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Atp7atm1.1Mjp/Y,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Rad54btm1Roka/Rad54btm1Roka
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Atp7aMo-Tohm/Y
Genetic Background: B6.Cg-Atp7aMo-Tohm

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Atp7aMo-dp2/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7atm1.1Mjp/Y,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-ml/Y
Genetic Background: C3Hf/He

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp7aMo-Tohm/Atp7a+
Genetic Background: B6.Cg-Atp7aMo-Tohm

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp7aMo-Tohm/Y
Genetic Background: B6.Cg-Atp7aMo-Tohm

Allelic Composition: Atp7aMo-Tohm/Atp7a+
Genetic Background: B6.Cg-Atp7aMo-Tohm

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-vbr/Y
Genetic Background: Not Specified

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Atp7aMo-blo/Atp7aMo-blo
Genetic Background: Not Specified

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Atp7aMo-blo/Atp7aMo-br
Genetic Background: involves: C57BL

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-Tohm/Y
Genetic Background: B6.Cg-Atp7aMo-Tohm

 MP:0002074 abnormal hair texture "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-dp2/Atp7a+
Genetic Background: Not Specified

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atp7aMo-pew3J/Atp7a+
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

Allelic Composition: Atp7aMo-pew3J/Y
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

Allelic Composition: Atp7aMo-vbr/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-pew/Atp7a+
Genetic Background: CBA/J-Atp7aMo-pew

Allelic Composition: Atp7aMo-pew/Y
Genetic Background: CBA/J-Atp7aMo-pew

Allelic Composition: Atp7aMo-dp2/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Atp7aMo-3Btlr/Atp7aMo-3Btlr
Genetic Background: C57BL/6J-Atp7aMo-3Btlr

Allelic Composition: Atp7aMo-3Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-3Btlr

Allelic Composition: Atp7aMo-9J/Atp7a+
Genetic Background: involves: C57BL/6J

Allelic Composition: Atp7aMo-pew2J/Y
Genetic Background: involves: C57BL/6J * SJL/J

Allelic Composition: Atp7aMo-pew2J/Atp7a+
Genetic Background: involves: C57BL/6J * SJL/J

Allelic Composition: Atp7aMo-8J/Y
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Atp7aMo-8J/Atp7a+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Atp7aMo-ml/Y
Genetic Background: C3Hf/He

Allelic Composition: Atp7aMo-5J/Y
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * BALB/c * C57BL/6 * CBA

Allelic Composition: Atp7aMo-18H/Y
Genetic Background: involves: 101/H

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-vbr/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-dp2/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Atp7aMo-8J/Y
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-pew3J/Y
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

Allelic Composition: Atp7aMo-pew3J/Atp7aMo-pew3J
Genetic Background: C;B6-Atp7aMo-pew3J/GrsrJ

Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-vbr/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7aMo-blo
Genetic Background: Not Specified

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-l32J/Myo5ad-l32J
Genetic Background: B6.Cg-Myo5ad-l32J/GrsrJ

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-11H/Y
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atp7aMo-dp/Y
Genetic Background: Not Specified

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-blo/Atp7aMo-br
Genetic Background: involves: C57BL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp7aMo-blo/Atp7aMo-br
Genetic Background: involves: C57BL

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp7aMo-ms/Y
Genetic Background: Not Specified

 MP:0002826 tonic seizures "increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-ml/Y
Genetic Background: C3Hf/He

 MP:0002832 coarse hair "hair shafts that are twisted or coiled and are of uneven thickness produce an overall rugged or uneven appearance and roughness to the touch" [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:56826]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7a+
Genetic Background: Not Specified

 MP:0002845 abnormal aortic weight "any change from the normal state in the physical heaviness of the aorta" [RGD:Rat Genome Database submission]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-vbr/Y
Genetic Background: Not Specified

 MP:0002861 abnormal tail bud morphology "anomalous formation of the primordial region of the embryo that arises to form the tail of the adult; appears approximately ten days following conception as a short stump, and then initiates elongation and thinning in normal development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7atm1.1Mjp/Y,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0003065 abnormal hepatic copper content "anomalous level of copper present in the liver tissue" [RGD:Rat Genome Database submission]
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Allelic Composition: Runx1tm3Spe/Runx1tm3Spe,Spi1tm2.1Dgt/Spi1tm2.1Dgt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003067 decreased hepatic copper content "a reduced amount of copper in the liver tissue compared to controls" [RGD:Rat Genome Database submission]
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Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Atp7aMo-ms/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-ms/Y
Genetic Background: involves: CBA/Kw

 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
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Allelic Composition: Atp7aMo-vbr/Y
Genetic Background: Not Specified

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Atp7aMo-ms/Y
Genetic Background: Not Specified

 MP:0003211 abnormal aorta elastic fiber morphology "malformation of a slender connective tissue fiber in aortic tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Atp7aMo-Tohm/Atp7a+
Genetic Background: B6.Cg-Atp7aMo-Tohm

Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-vbr/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7a+
Genetic Background: Not Specified

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Atp7aMo-Tohm/Y
Genetic Background: B6.Cg-Atp7aMo-Tohm

 MP:0003279 aneurysm "a protruding sac formed by the dilation of the wall of an artery, a vein, or the heart resulting from a weakening of the vessel wall or heart muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Atp7aMo-blo/Atp7a+
Genetic Background: Not Specified

 MP:0003415 priapism "prolonged penile erection, often painful and without sexual desire " [smb:Susan M Bello, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
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Allelic Composition: Atp7aMo-blo/Atp7aMo-blo
Genetic Background: Not Specified

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp7aMo-blo/Atp7aMo-blo
Genetic Background: Not Specified

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp7atm1.1Mjp/Y,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0003907 decreased aorta elastin content "reduction in the physical amount of elastin in the aorta compared to the normal state" [RGD:Rat Genome Database submission]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7a+
Genetic Background: Not Specified

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Atp7aMo-ms/Y
Genetic Background: Not Specified

 MP:0003951 abnormal copper homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in a number of proteins including amine oxidases and chaperone proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp7aMo-ms/Y
Genetic Background: involves: CBA/Kw

 MP:0003952 abnormal copper level "anomaly in the concentration in the body with respect to this metallic element that normally occurs in a number of proteins including amine oxidases and chaperone proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rad54btm1Roka/Rad54btm1Roka
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Atp7aMo-ms/Y
Genetic Background: Not Specified

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-br/Y
Genetic Background: involves: C57BL

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-Tohm/Y
Genetic Background: B6.Cg-Atp7aMo-Tohm

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-ms/Y
Genetic Background: Not Specified

 MP:0004508 abnormal shoulder bone morphology "any structural anomaly of the bones of the shoulder by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-dp/Y
Genetic Background: Not Specified

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-dp/Y
Genetic Background: Not Specified

 MP:0004676 wide ribs "an increase in the width of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Atp7aMo-dp/Y
Genetic Background: Not Specified

 MP:0004882 enlarged lung "increased size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-blo/Atp7aMo-br
Genetic Background: involves: C57BL

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-ml/Y
Genetic Background: C3Hf/He

 MP:0005171 lack of coat pigmentation "fur is devoid of coloration and appears white " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Atp7aMo-10H/Y
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atp7aMo-2Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-2Btlr

Allelic Composition: Atp7aMo-ml/Y
Genetic Background: C3Hf/He

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7a+
Genetic Background: Not Specified

 MP:0005243 hemothorax "bleeding into the pleural space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7a+
Genetic Background: Not Specified

 MP:0005363 decreased susceptibility to prion infection "reduced likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp7aMo-3Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-3Btlr

 MP:0005366 variegated coat color "dappled coloration of the fur; mosaic" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-N/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-17H/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-16H/Atp7a+
Genetic Background: SWF

Allelic Composition: Atp7aMo-spot/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-10H/Atp7a+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atp7aMo-11H/Atp7a+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atp7aMo-12H/Atp7a+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atp7aMo-dp/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-dp/Atp7a+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0005435 hemoperitoneum "blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293]
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Allelic Composition: Atp7aMo-blo/Atp7a+
Genetic Background: Not Specified

 MP:0005503 abnormal tendon morphology "structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509]
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Allelic Composition: Atp7aMo-dp2/Atp7a+
Genetic Background: Not Specified

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp7aMo-dp/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-dp2/Atp7a+
Genetic Background: Not Specified

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp7aMo-blo/Atp7aMo-blo
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/?
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-dp/Atp7a+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0006208 embryonic lethality throughout fetal growth and development "death anytime after the completion of organogenesis but before E18.5 (E14 to less than E18.5)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm5Mgmj/Leprtm5Mgmj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006278 aortic aneurysm "protruding sac formed by dilation of the aorta" [J:110586, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-vbr/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7aMo-blo
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-dp/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-to/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-to/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7aMo-br
Genetic Background: involves: C57BL

 MP:0006349 decreased circulating copper level "less than the normal concentration of copper in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", Riken ENU:Hiroshi Masuya]
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Allelic Composition: Atp7aMo-br/Y
Genetic Background: involves: C57BL

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-vbr/Y
Genetic Background: Not Specified

 MP:0008731 abnormal hair shaft melanin granules "any amount or distribution anomaly of pigment polymers in the hair shaft" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-dp2/Atp7a+
Genetic Background: Not Specified

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-brJ/Y,Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

Allelic Composition: Atp7aMo-brJ/Atp7a+,Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ

 MP:0009901 abnormal frontonasal prominence morphology "any structural anomaly of an unpaired facial process in the embryo formed from the tissues surrounding the forebrain vesicle that develops into the forehead and bridge of the nose/snout" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Atp7atm1.1Mjp/Y,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0010016 variable depigmentation "absence or loss of normal pigment in the skin in various and irregular patterns" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010243 increased kidney copper level "a greater accumulation of copper in the kidney tissue compared to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-ms/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-ms/Y
Genetic Background: involves: CBA

 MP:0010247 increased intestine copper level "a greater accumulation of copper in intestinal tissue compared with controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-br/Y
Genetic Background: involves: C57BL

Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Atp7aMo-ms/Y
Genetic Background: involves: CBA/Kw

 MP:0010389 mosaic coat color "a random coat color pattern due to genetically different populations of cells in the skin e.g. as the result of X-inactivation" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tyrc-Btlr/Tyrc-Btlr
Genetic Background: C57BL/6J-Tyrc-Btlr

Allelic Composition: Atp7aMo-2Btlr/Atp7a+
Genetic Background: C57BL/6J-Atp7aMo-2Btlr

Allelic Composition: Atp7aMo-8J/Atp7a+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Atp7a+/Atp7aMo-5J
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0010470 ascending aorta dilation "the luminal space of the ascending aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

 MP:0010574 aorta dilation "the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-blo/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-blo/Atp7a+
Genetic Background: Not Specified

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-ml/Y
Genetic Background: C3Hf/He

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-blo/Atp7aMo-br
Genetic Background: involves: C57BL

 MP:0010895 increased lung compliance "increased ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
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Allelic Composition: Atp7aMo-blo/Atp7aMo-br
Genetic Background: involves: C57BL

 MP:0010900 abnormal pulmonary interalveolar septum morphology "any structural anomaly of the tissue intervening between two adjacent pulmonary alveoli, which consists of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium; thicker alveolar septal regions may also contain elastic fibers, collagen, interstitial cells, smooth muscle cells, mast cells, lymphocytes and monocytes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-blo/Atp7aMo-br
Genetic Background: involves: C57BL

 MP:0010908 dilated pulmonary alveolar ducts "expansion or widening of the lumens of the respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp7aMo-blo/Atp7aMo-br
Genetic Background: involves: C57BL

 MP:0010937 increased total lung capacity "greater volume of air contained in the lungs at the end of maximal inspiration" [MGI:csmith]
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Allelic Composition: Atp7aMo-blo/Atp7aMo-br
Genetic Background: involves: C57BL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Atp7aMo-10H/Y
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atp7aMo-13H/Y
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atp7aMo-2Acre/Y
Genetic Background: involves: 101 * C3H * T STOCK

Allelic Composition: Atp7aMo-2Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-2Btlr

Allelic Composition: Atp7aMo-brJ/Y,Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

Allelic Composition: Atp7aMo-ms/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-ms/Y
Genetic Background: involves: CBA/Kw

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atp7aMo-Tohm/Atp7a+
Genetic Background: B6.Cg-Atp7aMo-Tohm

Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Tyrc-Btlr/Tyrc-Btlr
Genetic Background: C57BL/6J-Tyrc-Btlr

Allelic Composition: Atp7aMo-dp/Y
Genetic Background: Not Specified

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Atp7aMo-11H/Atp7a+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Atp7aMo-N/Atp7a+
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-ca/Atp7aMo-ca
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-ca/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-11H/Y
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atp7aMo-Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-Btlr

Allelic Composition: Atp7aMo-12DFiOD/Y
Genetic Background: involves: 101 * C3H * T STOCK

Allelic Composition: Atp7aMo-1Pub/Y
Genetic Background: involves: 101 * C3H * T STOCK

Allelic Composition: Atp7aMo-8R/Y
Genetic Background: involves: 101 * C3H * T STOCK

Allelic Composition: Atp7aMo-7R/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-7ENURF/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-Xm/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-4R/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-9J/Y
Genetic Background: involves: C57BL/6J

Allelic Composition: Atp7atm1.1Mjp/Y,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Atp7aMo-brJ/Atp7a+,Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atp7aMo-Tohm/Y
Genetic Background: involves: AA * C3H/He * C57BL/6 * ICR

Allelic Composition: Atp7aMo-Tohm/Y
Genetic Background: B6.Cg-Atp7aMo-Tohm

Allelic Composition: Atp7aMo-dp2/Y
Genetic Background: Not Specified

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Atp7aMo-11H/Y
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Atp7aMo-5J/Y
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atp7aMo-2Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-2Btlr

Allelic Composition: Atp7atm1.1Mjp/Atp7a+,Cldn6tm1(cre)Dkwu/Cldn6+
Genetic Background: involves: C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Atp7aMo-brJ/Y,Mt1tm1Bri/Mt1tm1Bri,Mt2tm1Bri/Mt2tm1Bri
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Atp7aMo-dp/Y
Genetic Background: Not Specified

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Atp7aMo-ml/Y
Genetic Background: C3Hf/He

Allelic Composition: Atp7aMo-ml/Y
Genetic Background: involves: C3Hf/He * C57BL/6

 MP:0011215 decreased brain copper level "a reduced amount of copper in the brain tissue compared to controls" [MGI:llw2]
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Allelic Composition: Atp7aMo-Tohm/Atp7a+
Genetic Background: B6.Cg-Atp7aMo-Tohm

Allelic Composition: Atp7aMo-br/Y
Genetic Background: involves: C57BL

Allelic Composition: Atp7aMo-3Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-3Btlr

Allelic Composition: Atp7aMo-ms/Y
Genetic Background: Not Specified

Allelic Composition: Atp7aMo-ms/Y
Genetic Background: involves: CBA/Kw

Allelic Composition: Atp7aMo-dp/Atp7a+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0012574 decreased noradrenaline level "reduced amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine" [http://orcid.org/0000-0001-5208-3432, ISBN:0198506732]
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Allelic Composition: Atp7aMo-dp/Atp7a+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0012661 decreased circulating ceruloplasmin level 
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Allelic Composition: Atp7aMo-ms/Y
Genetic Background: involves: CBA/Kw

 MP:0014178 increased brain apoptosis "increase in the number of cells of the brain undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Atp7aMo-Tohm/Atp7a+
Genetic Background: B6.Cg-Atp7aMo-Tohm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015668 Pdzd11 / Q9CZG9 / PDZ domain-containing protein 11 / Q5EBL8* / PDZ domain containing 11*  / complex
 ENSMUSG00000018585 Atox1 / O08997 / Copper transport protein ATOX1 / O00244* / antioxidant 1 copper chaperone*  / reaction






 

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