ENSDARG00000006029


Danio rerio

Features
Gene ID: ENSDARG00000006029
  
Biological name :lta4h
  
Synonyms : leukotriene A4 hydrolase / lta4h
  
Possible biological names infered from orthology : P09960 / P24527
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 7653607
Gene end: 7673165
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000011882
NCBI entrez gene - 406575     See in Manteia.
RefSeq - NM_213286
RefSeq Peptide - NP_998451
swissprot - A5PMQ1
ZFIN ID - ZDB-GENE-040426-2477
Ensembl - ENSDARG00000006029
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LTA4HENSGALG00000033709Gallus gallus
 LTA4HENSG00000111144Homo sapiens
 Lta4hENSMUSG00000015889Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rnpep / arginyl aminopeptidase (aminopeptidase B) / Q8VCT3* / Q9H4A4* / arginyl aminopeptidase*ENSDARG0000001250635
rnpepl1 / arginyl aminopeptidase like 1 / Q9HAU8*ENSDARG0000000781330


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR012777  Leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR015211  Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal
 IPR016024  Armadillo-type fold
 IPR034015  Leukotriene A4 hydrolase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0019370 leukotriene biosynthetic process IEA
 biological_processGO:0030593 neutrophil chemotaxis IMP
 biological_processGO:0043171 peptide catabolic process IBA
 biological_processGO:0044255 cellular lipid metabolic process IBA
 biological_processGO:0055113 epiboly involved in gastrulation with mouth forming second IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004301 epoxide hydrolase activity IBA
 molecular_functionGO:0004463 leukotriene-A4 hydrolase activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IBA


Pathways (from Reactome)
Pathway description
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Neutrophil degranulation
Biosynthesis of D-series resolvins
Biosynthesis of protectins
Biosynthesis of E-series 18(S)-resolvins
Biosynthesis of aspirin-triggered D-series resolvins
Biosynthesis of E-series 18(R)-resolvins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism decreased life span , exacerbated
Show

 ZFA:0009141 macrophage macrophage aggregated , ameliorated
macrophage aggregated , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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