ENSG00000111144


Homo sapiens

Features
Gene ID: ENSG00000111144
  
Biological name :LTA4H
  
Synonyms : leukotriene A4 hydrolase / LTA4H / P09960
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q23.1
Gene start: 96000828
Gene end: 96043520
  
Corresponding Affymetrix probe sets: 208771_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449340
Ensembl peptide - ENSP00000449958
Ensembl peptide - ENSP00000228740
Ensembl peptide - ENSP00000395051
NCBI entrez gene - 4048     See in Manteia.
OMIM - 151570
RefSeq - XM_011538349
RefSeq - NM_000895
RefSeq - NM_001256643
RefSeq - NM_001256644
RefSeq - XM_005268871
RefSeq - XM_011538348
RefSeq Peptide - NP_001243572
RefSeq Peptide - NP_001243573
RefSeq Peptide - NP_000886
swissprot - B4DEH5
swissprot - P09960
swissprot - A0A140VK27
Ensembl - ENSG00000111144
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lta4hENSDARG00000006029Danio rerio
 LTA4HENSGALG00000033709Gallus gallus
 Lta4hENSMUSG00000015889Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RNPEP / Q9H4A4 / arginyl aminopeptidaseENSG0000017639337
Q9HAU8 / RNPEPL1 / arginyl aminopeptidase like 1ENSG0000014232732
C9orf3 / Q8N6M6 / chromosome 9 open reading frame 3ENSG0000014812024


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR012777  Leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR015211  Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal
 IPR016024  Armadillo-type fold
 IPR034015  Leukotriene A4 hydrolase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006691 leukotriene metabolic process TAS
 biological_processGO:0019370 leukotriene biosynthetic process TAS
 biological_processGO:0043171 peptide catabolic process IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0044255 cellular lipid metabolic process IBA
 biological_processGO:0044267 cellular protein metabolic process IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904724 tertiary granule lumen TAS
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004177 aminopeptidase activity IDA
 molecular_functionGO:0004301 epoxide hydrolase activity IMP
 molecular_functionGO:0004463 leukotriene-A4 hydrolase activity TAS
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity TAS
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IMP


Pathways (from Reactome)
Pathway description
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Neutrophil degranulation
Biosynthesis of D-series resolvins
Biosynthesis of protectins
Biosynthesis of E-series 18(S)-resolvins
Biosynthesis of aspirin-triggered D-series resolvins
Biosynthesis of E-series 18(R)-resolvins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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