ENSMUSG00000015889


Mus musculus

Features
Gene ID: ENSMUSG00000015889
  
Biological name :Lta4h
  
Synonyms : Leukotriene A-4 hydrolase / Lta4h / P24527
  
Possible biological names infered from orthology : P09960
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C2
Gene start: 93453411
Gene end: 93484875
  
Corresponding Affymetrix probe sets: 10365749 (MoGene1.0st)   1426807_at (Mouse Genome 430 2.0 Array)   1434790_a_at (Mouse Genome 430 2.0 Array)   1453528_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016033
NCBI entrez gene - 16993     See in Manteia.
MGI - MGI:96836
RefSeq - NM_008517
RefSeq - NM_001313897
RefSeq Peptide - NP_001300826
RefSeq Peptide - NP_032543
swissprot - P24527
Ensembl - ENSMUSG00000015889
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lta4hENSDARG00000006029Danio rerio
 LTA4HENSGALG00000033709Gallus gallus
 LTA4HENSG00000111144Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rnpep / Q8VCT3 / arginyl aminopeptidase (aminopeptidase B) / Q9H4A4* / arginyl aminopeptidase*ENSMUSG0000004192637
G5E872 / Rnpepl1 / Aminopeptidase RNPEPL1 / Q9HAU8* / arginyl aminopeptidase like 1*ENSMUSG0000002626932
2010111I01Rik / chromosome 9 open reading frame 3 / C9orf3* / Q8N6M6*ENSMUSG0000002145823


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR012777  Leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR015211  Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal
 IPR016024  Armadillo-type fold
 IPR034015  Leukotriene A4 hydrolase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0019370 leukotriene biosynthetic process ISS
 biological_processGO:0043171 peptide catabolic process IEA
 biological_processGO:0044255 cellular lipid metabolic process IBA
 biological_processGO:0044267 cellular protein metabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004177 aminopeptidase activity IEA
 molecular_functionGO:0004301 epoxide hydrolase activity IEA
 molecular_functionGO:0004463 leukotriene-A4 hydrolase activity ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Neutrophil degranulation
Biosynthesis of D-series resolvins
Biosynthesis of protectins
Biosynthesis of E-series 18(S)-resolvins
Biosynthesis of aspirin-triggered D-series resolvins
Biosynthesis of E-series 18(R)-resolvins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Hexatm1Cota/Hexatm1Cota
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hexatm1Cota/Hexatm1Cota
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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