ENSDARG00000006524


Danio rerio

Features
Gene ID: ENSDARG00000006524
  
Biological name :supt6h
  
Synonyms : Q8UVK2 / SPT6 homolog, histone chaperone / supt6h
  
Possible biological names infered from orthology : Q62383 / Q7KZ85 / Supt6 / Transcription elongation factor SPT6
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 26028947
Gene end: 26058547
  
Corresponding Affymetrix probe sets: Dr.6422.1.S1_at (Zebrafish Array)   NM_145118_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000013353
NCBI entrez gene - 337866     See in Manteia.
RefSeq - XM_009295470
RefSeq - NM_145118
RefSeq Peptide - NP_660094
swissprot - Q8UVK2
ZFIN ID - ZDB-GENE-030131-7949
Ensembl - ENSDARG00000006524
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SUPT6HENSGALG00000000146Gallus gallus
 Q7KZ85ENSG00000109111Homo sapiens
 Supt6ENSMUSG00000002052Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR003029  S1 domain
 IPR006641  YqgF/RNase H-like domain
 IPR010994  RuvA domain 2-like
 IPR012337  Ribonuclease H-like superfamily
 IPR012340  Nucleic acid-binding, OB-fold
 IPR017072  Transcription elongation factor Spt6
 IPR023319  Tex-like protein, HTH domain superfamily
 IPR023323  Tex-like domain superfamily
 IPR027999  Death-like domain of Spt6
 IPR028083  Spt6 acidic, N-terminal domain
 IPR028088  Helix-turn-helix DNA-binding domain of Spt6
 IPR028231  Transcription elongation factor Spt6, YqgF domain
 IPR032706  Transcription elongation factor Spt6, helix-hairpin-helix motif
 IPR035018  Spt6, SH2 domain, C terminus
 IPR035019  Spt6, SH2 domain, N terminus
 IPR035420  Spt6, SH2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IBA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0032784 regulation of DNA-templated transcription, elongation IEA
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter ISS
 biological_processGO:0034728 nucleosome organization IBA
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IBA
 biological_processGO:0050684 regulation of mRNA processing IBA
 biological_processGO:0061086 negative regulation of histone H3-K27 methylation IMP
 biological_processGO:0070827 chromatin maintenance IBA
 biological_processGO:0071599 otic vesicle development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0008023 transcription elongation factor complex IBA
 cellular_componentGO:0035327 transcriptionally active chromatin IBA
 molecular_functionGO:0000991 transcription factor activity, core RNA polymerase II binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0031491 nucleosome binding IBA
 molecular_functionGO:0042393 histone binding IBA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
brain morphology , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle dilated , abnormal
cardiac ventricle decreased size , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle shape , abnormal
otic vesicle decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000074 somite 26 somite 26 aplastic , abnormal
Show

 ZFA:0000084 yolk yolk shape , abnormal
yolk dark grey , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye morphology , abnormal
Show

 ZFA:0000114 heart heart decreased size , abnormal
heart quality , abnormal
heart morphology , abnormal
Show

 ZFA:0000152 retina retina ventral region aplastic , abnormal
Show

 ZFA:0000156 somite 20 somite 20 aplastic , abnormal
Show

 ZFA:0000157 somite 30 somite 30 aplastic , abnormal
Show

 ZFA:0000217 inner ear inner ear quality , abnormal
inner ear morphology , abnormal
inner ear has fewer parts of type otolith , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000360 heart tube heart tube aplastic , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal aplastic , abnormal
Show

 ZFA:0000471 atrium atrium aplastic , abnormal
atrium dilated , abnormal
atrium position , abnormal
atrium attached to bulbus arteriosus , abnormal
Show

 ZFA:0000725 somite 11 somite 11 aplastic , abnormal
Show

 ZFA:0000726 somite 14 somite 14 aplastic , abnormal
Show

 ZFA:0000727 somite 17 somite 17 aplastic , abnormal
Show

 ZFA:0000730 somite 23 somite 23 aplastic , abnormal
Show

 ZFA:0000731 somite 27 somite 27 aplastic , abnormal
Show

 ZFA:0000733 somite 7 somite 7 malformed , abnormal
Show

 ZFA:0000851 somite 12 somite 12 aplastic , abnormal
Show

 ZFA:0000852 somite 15 somite 15 aplastic , abnormal
Show

 ZFA:0000853 somite 18 somite 18 aplastic , abnormal
Show

 ZFA:0000854 somite 21 somite 21 aplastic , abnormal
Show

 ZFA:0000855 somite 24 somite 24 aplastic , abnormal
Show

 ZFA:0000856 somite 28 somite 28 aplastic , abnormal
Show

 ZFA:0000858 somite 8 somite 8 aplastic , abnormal
Show

 ZFA:0000974 somite 10 somite 10 aplastic , abnormal
Show

 ZFA:0000975 somite 13 somite 13 aplastic , abnormal
Show

 ZFA:0000976 somite 16 somite 16 aplastic , abnormal
Show

 ZFA:0000977 somite 19 somite 19 aplastic , abnormal
Show

 ZFA:0000978 somite 22 somite 22 aplastic , abnormal
Show

 ZFA:0000980 somite 25 somite 25 aplastic , abnormal
Show

 ZFA:0000981 somite 29 somite 29 aplastic , abnormal
Show

 ZFA:0000982 somite 6 somite 6 malformed , abnormal
Show

 ZFA:0000983 somite 9 somite 9 aplastic , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased pigmentation , abnormal
whole organism bent , abnormal
whole organism decreased length , abnormal
whole organism shape , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001115 trunk trunk curved ventral , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased size , abnormal
post-vent region quality , abnormal
post-vent region morphology , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001462 somite border somite border degenerate , abnormal
Show

 ZFA:0001617 otolith otolith quality , abnormal
otolith decreased size , abnormal
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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