ENSMUSG00000002052


Mus musculus

Features
Gene ID: ENSMUSG00000002052
  
Biological name :Supt6
  
Synonyms : Q62383 / Supt6 / Transcription elongation factor SPT6
  
Possible biological names infered from orthology : Q7KZ85 / SPT6 homolog, histone chaperone / SUPT6H
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 78206746
Gene end: 78245987
  
Corresponding Affymetrix probe sets: 10388786 (MoGene1.0st)   1417628_at (Mouse Genome 430 2.0 Array)   1430458_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002121
NCBI entrez gene - 20926     See in Manteia.
MGI - MGI:107726
RefSeq - NM_009297
RefSeq - XM_006532743
RefSeq Peptide - NP_033323
swissprot - Q62383
Ensembl - ENSMUSG00000002052
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q8UVK2ENSDARG00000006524Danio rerio
 SUPT6HENSGALG00000000146Gallus gallus
 Q7KZ85ENSG00000109111Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR003029  S1 domain
 IPR006641  YqgF/RNase H-like domain
 IPR010994  RuvA domain 2-like
 IPR012337  Ribonuclease H-like superfamily
 IPR012340  Nucleic acid-binding, OB-fold
 IPR017072  Transcription elongation factor Spt6
 IPR022967  RNA-binding domain, S1
 IPR023319  Tex-like protein, HTH domain superfamily
 IPR023323  Tex-like domain superfamily
 IPR027999  Death-like domain of Spt6
 IPR028083  Spt6 acidic, N-terminal domain
 IPR028088  Helix-turn-helix DNA-binding domain of Spt6
 IPR028231  Transcription elongation factor Spt6, YqgF domain
 IPR032706  Transcription elongation factor Spt6, helix-hairpin-helix motif
 IPR035018  Spt6, SH2 domain, C terminus
 IPR035019  Spt6, SH2 domain, N terminus
 IPR035420  Spt6, SH2 domain
 IPR036860  SH2 domain superfamily
 IPR037027  YqgF/RNase H-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010793 regulation of mRNA export from nucleus IMP
 biological_processGO:0032784 regulation of DNA-templated transcription, elongation IEA
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0034728 nucleosome organization IBA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IBA
 biological_processGO:0045191 regulation of isotype switching IMP
 biological_processGO:0050684 regulation of mRNA processing IMP
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051147 regulation of muscle cell differentiation IMP
 biological_processGO:0061086 negative regulation of histone H3-K27 methylation IEA
 biological_processGO:0070827 chromatin maintenance IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0008023 transcription elongation factor complex IBA
 cellular_componentGO:0035327 transcriptionally active chromatin IBA
 molecular_functionGO:0000991 transcription factor activity, core RNA polymerase II binding IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031491 nucleosome binding IBA
 molecular_functionGO:0042393 histone binding IEA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Ctnna1Gt(fVET3A)Hiir/Ctnna1Gt(fVET3A)Hiir
Genetic Background: involves: C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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