ENSG00000109111


Homo sapiens

Features
Gene ID: ENSG00000109111
  
Biological name :SUPT6H
  
Synonyms : Q7KZ85 / SPT6 homolog, histone chaperone / SUPT6H
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q11.2
Gene start: 28662091
Gene end: 28702684
  
Corresponding Affymetrix probe sets: 1554311_a_at (Human Genome U133 Plus 2.0 Array)   208420_x_at (Human Genome U133 Plus 2.0 Array)   208830_s_at (Human Genome U133 Plus 2.0 Array)   208831_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000319104
Ensembl peptide - ENSP00000338143
Ensembl peptide - ENSP00000464545
Ensembl peptide - ENSP00000465508
NCBI entrez gene - 6830     See in Manteia.
OMIM - 601333
RefSeq - XM_017024980
RefSeq - NM_001320755
RefSeq - NM_003170
RefSeq - XM_017024978
RefSeq - XM_017024979
RefSeq Peptide - NP_003161
RefSeq Peptide - NP_001307684
swissprot - K7EK85
swissprot - Q7KZ85
swissprot - J3QS64
Ensembl - ENSG00000109111
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q8UVK2ENSDARG00000006524Danio rerio
 SUPT6HENSGALG00000000146Gallus gallus
 Supt6ENSMUSG00000002052Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR003029  S1 domain
 IPR006641  YqgF/RNase H-like domain
 IPR010994  RuvA domain 2-like
 IPR012337  Ribonuclease H-like superfamily
 IPR012340  Nucleic acid-binding, OB-fold
 IPR017072  Transcription elongation factor Spt6
 IPR022967  RNA-binding domain, S1
 IPR023319  Tex-like protein, HTH domain superfamily
 IPR023323  Tex-like domain superfamily
 IPR027999  Death-like domain of Spt6
 IPR028083  Spt6 acidic, N-terminal domain
 IPR028088  Helix-turn-helix DNA-binding domain of Spt6
 IPR028231  Transcription elongation factor Spt6, YqgF domain
 IPR032706  Transcription elongation factor Spt6, helix-hairpin-helix motif
 IPR035018  Spt6, SH2 domain, C terminus
 IPR035019  Spt6, SH2 domain, N terminus
 IPR035420  Spt6, SH2 domain
 IPR036860  SH2 domain superfamily
 IPR037027  YqgF/RNase H-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0006338 chromatin remodeling NAS
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010793 regulation of mRNA export from nucleus ISS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0032784 regulation of DNA-templated transcription, elongation IEA
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IMP
 biological_processGO:0034728 nucleosome organization IBA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IBA
 biological_processGO:0045191 regulation of isotype switching ISS
 biological_processGO:0050684 regulation of mRNA processing IBA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051147 regulation of muscle cell differentiation ISS
 biological_processGO:0061086 negative regulation of histone H3-K27 methylation IMP
 biological_processGO:0070827 chromatin maintenance IBA
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0008023 transcription elongation factor complex IBA
 cellular_componentGO:0035327 transcriptionally active chromatin IBA
 molecular_functionGO:0000991 transcription factor activity, core RNA polymerase II binding IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031491 nucleosome binding IBA
 molecular_functionGO:0042393 histone binding IDA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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