ENSDARG00000006602


Danio rerio

Features
Gene ID: ENSDARG00000006602
  
Biological name :chrna2a
  
Synonyms : cholinergic receptor, nicotinic, alpha 2a (neuronal) / chrna2a
  
Possible biological names infered from orthology : cholinergic receptor nicotinic alpha 2 subunit / cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) / CHRNA2 / Q15822 / Q91X60
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 6079881
Gene end: 6101820
  
Corresponding Affymetrix probe sets: Dr.26447.1.S1_at (Zebrafish Array)   NM_001040327_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000028704
NCBI entrez gene - 678575     See in Manteia.
RefSeq - NM_001040327
RefSeq Peptide - NP_001035417
swissprot - Q1RLX8
ZFIN ID - ZDB-GENE-040108-2
Ensembl - ENSDARG00000006602
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CHRNA2ENSGALG00000016565Gallus gallus
 CHRNA2ENSG00000120903Homo sapiens
 Chrna2ENSMUSG00000022041Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
chrna2b / cholinergic receptor, nicotinic, alpha 2b (neuronal) / CHRNA2* / Q15822* / Q91X60* / cholinergic receptor nicotinic alpha 2 subunit* / cholinergic receptor, nicotinic, alpha polyp...ENSDARG0000005702577
chrna4b / cholinergic receptor, nicotinic, alpha 4b / CHRNA4* / O70174* / P43681* / cholinergic receptor nicotinic alpha 4 subunit* / cholinergic receptor, nicotinic, alpha polypeptide 4*ENSDARG0000007072467
chrna4a / cholinergic receptor, nicotinic, alpha 4a / CHRNA4* / O70174* / P43681* / cholinergic receptor nicotinic alpha 4 subunit* / cholinergic receptor, nicotinic, alpha polypeptide 4*ENSDARG0000008707157
chrna6 / cholinergic receptor, nicotinic, alpha 6 / Q15825* / Q9R0W9* / cholinergic receptor nicotinic alpha 6 subunit* / cholinergic receptor, nicotinic, alpha polypeptide 6*ENSDARG0000005555953
chrna3 / cholinergic receptor, nicotinic, alpha 3 / P32297* / cholinergic receptor nicotinic alpha 3 subunit* / cholinergic receptor, nicotinic, alpha polypeptide 3*ENSDARG0000010099152
chrnb3a / cholinergic receptor, nicotinic, beta polypeptide 3a / Q8BMN3* / CHRNB3* / Q05901* / cholinergic receptor nicotinic beta 3 subunit* / cholinergic receptor, nicotinic, beta polypeptide 3*ENSDARG0000005276446
chrna5 / cholinergic receptor, nicotinic, alpha 5 / P30532* / Q2MKA5* / cholinergic receptor nicotinic alpha 5 subunit* / cholinergic receptor, nicotinic, alpha polypeptide 5*ENSDARG0000000342046
chrnb2b / cholinergic receptor, nicotinic, beta 2b / CHRNB2* / P17787* / Q9ERK7* / cholinergic receptor nicotinic beta 2 subunit* / cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)*ENSDARG0000001779045
chrnb4 / cholinergic receptor, nicotinic, beta 4 (neuronal) / P30926* / Q8R493* / cholinergic receptor nicotinic beta 4 subunit* / cholinergic receptor, nicotinic, beta polypeptide 4*ENSDARG0000010167745
chrnb3b / cholinergic receptor, nicotinic, beta 3b (neuronal) / CHRNB3* / Q05901* / Q8BMN3* / cholinergic receptor nicotinic beta 3 subunit* / cholinergic receptor, nicotinic, beta polypeptide 3*ENSDARG0000003850845
chrnb2a / cholinergic receptor, nicotinic, beta 2aENSDARG0000011577844
Q98880 / chrna1 / cholinergic receptor, nicotinic, alpha 1 (muscle) / P02708* / P04756* / cholinergic receptor nicotinic alpha 1 subunit* / cholinergic receptor, nicotinic, alpha polypeptid...ENSDARG0000000902141
chrnb2l / cholinergic receptor, nicotinic, beta 2, likeENSDARG0000002139240


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007271 synaptic transmission, cholinergic IBA
 biological_processGO:0007274 neuromuscular synaptic transmission IBA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035094 response to nicotine IBA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0098655 cation transmembrane transport IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005892 acetylcholine-gated channel complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0015464 acetylcholine receptor activity IDA
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity IBA
 molecular_functionGO:0042166 acetylcholine binding IBA


Pathways (from Reactome)
Pathway description
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009125 olfactory receptor cell olfactory receptor cell absent , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006602 chrna2a / cholinergic receptor, nicotinic, alpha 2a (neuronal) / CHRNA2* / Q15822* / Q91X60* / cholinergic receptor nicotinic alpha 2 subunit* / cholinergic receptor, nicotinic, alpha polyp...  / complex
 ENSDARG00000057025 chrna2b / cholinergic receptor, nicotinic, alpha 2b (neuronal) / CHRNA2* / Q15822* / Q91X60* / cholinergic receptor nicotinic alpha 2 subunit* / cholinergic receptor, nicotinic, alpha polyp...  / complex
 ENSDARG00000038508 chrnb3b / cholinergic receptor, nicotinic, beta 3b (neuronal) / CHRNB3* / Q05901* / Q8BMN3* / cholinergic receptor nicotinic beta 3 subunit* / cholinergic receptor, nicotinic, beta polypeptide 3*  / complex






 

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