ENSDARG00000070724


Danio rerio

Features
Gene ID: ENSDARG00000070724
  
Biological name :chrna4b
  
Synonyms : cholinergic receptor, nicotinic, alpha 4b / chrna4b
  
Possible biological names infered from orthology : cholinergic receptor nicotinic alpha 4 subunit / cholinergic receptor, nicotinic, alpha polypeptide 4 / CHRNA4 / O70174 / P43681
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 12982260
Gene end: 12998400
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000022694
NCBI entrez gene - 556619     See in Manteia.
RefSeq - NM_001048063
RefSeq Peptide - NP_001041528
swissprot - Q0PJT8
ZFIN ID - ZDB-GENE-090505-3
Ensembl - ENSDARG00000070724
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CHRNA4ENSGALG00000005801Gallus gallus
 CHRNA4ENSG00000101204Homo sapiens
 Chrna4ENSMUSG00000027577Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
chrna2a / cholinergic receptor, nicotinic, alpha 2a (neuronal) / CHRNA2* / Q15822* / Q91X60* / cholinergic receptor nicotinic alpha 2 subunit* / cholinergic receptor, nicotinic, alpha polyp...ENSDARG0000000660255
chrna2b / cholinergic receptor, nicotinic, alpha 2b (neuronal) / CHRNA2* / Q15822* / Q91X60* / cholinergic receptor nicotinic alpha 2 subunit* / cholinergic receptor, nicotinic, alpha polyp...ENSDARG0000005702554
chrna4a / cholinergic receptor, nicotinic, alpha 4a / CHRNA4* / O70174* / P43681* / cholinergic receptor nicotinic alpha 4 subunit* / cholinergic receptor, nicotinic, alpha polypeptide 4*ENSDARG0000008707151
chrna6 / cholinergic receptor, nicotinic, alpha 6 / Q15825* / Q9R0W9* / cholinergic receptor nicotinic alpha 6 subunit* / cholinergic receptor, nicotinic, alpha polypeptide 6*ENSDARG0000005555943
chrna3 / cholinergic receptor, nicotinic, alpha 3 / P32297* / cholinergic receptor nicotinic alpha 3 subunit* / cholinergic receptor, nicotinic, alpha polypeptide 3*ENSDARG0000010099142
chrnb4 / cholinergic receptor, nicotinic, beta 4 (neuronal) / P30926* / Q8R493* / cholinergic receptor nicotinic beta 4 subunit* / cholinergic receptor, nicotinic, beta polypeptide 4*ENSDARG0000010167738
chrnb3a / cholinergic receptor, nicotinic, beta polypeptide 3a / Q8BMN3* / CHRNB3* / Q05901* / cholinergic receptor nicotinic beta 3 subunit* / cholinergic receptor, nicotinic, beta polypeptide 3*ENSDARG0000005276438
chrnb2b / cholinergic receptor, nicotinic, beta 2b / CHRNB2* / P17787* / Q9ERK7* / cholinergic receptor nicotinic beta 2 subunit* / cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)*ENSDARG0000001779037
chrnb2a / cholinergic receptor, nicotinic, beta 2aENSDARG0000011577837
chrnb3b / cholinergic receptor, nicotinic, beta 3b (neuronal) / CHRNB3* / Q05901* / Q8BMN3* / cholinergic receptor nicotinic beta 3 subunit* / cholinergic receptor, nicotinic, beta polypeptide 3*ENSDARG0000003850837
chrna5 / cholinergic receptor, nicotinic, alpha 5 / P30532* / Q2MKA5* / cholinergic receptor nicotinic alpha 5 subunit* / cholinergic receptor, nicotinic, alpha polypeptide 5*ENSDARG0000000342037
chrnb2l / cholinergic receptor, nicotinic, beta 2, likeENSDARG0000002139234
Q98880 / chrna1 / cholinergic receptor, nicotinic, alpha 1 (muscle) / P02708* / P04756* / cholinergic receptor nicotinic alpha 1 subunit* / cholinergic receptor, nicotinic, alpha polypeptid...ENSDARG0000000902134


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007271 synaptic transmission, cholinergic IBA
 biological_processGO:0007274 neuromuscular synaptic transmission IBA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035094 response to nicotine IDA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0098655 cation transmembrane transport IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005892 acetylcholine-gated channel complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0015464 acetylcholine receptor activity IDA
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity IBA
 molecular_functionGO:0042166 acetylcholine binding IBA


Pathways (from Reactome)
Pathway description
Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000070724 chrna4b / cholinergic receptor, nicotinic, alpha 4b / CHRNA4* / O70174* / P43681* / cholinergic receptor nicotinic alpha 4 subunit* / cholinergic receptor, nicotinic, alpha polypeptide 4*  / complex
 ENSDARG00000038508 chrnb3b / cholinergic receptor, nicotinic, beta 3b (neuronal) / CHRNB3* / Q05901* / Q8BMN3* / cholinergic receptor nicotinic beta 3 subunit* / cholinergic receptor, nicotinic, beta polypeptide 3*  / complex
 ENSDARG00000017790 chrnb2b / cholinergic receptor, nicotinic, beta 2b / CHRNB2* / P17787* / Q9ERK7* / cholinergic receptor nicotinic beta 2 subunit* / cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)*  / complex






 

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