ENSMUSG00000027577


Mus musculus

Features
Gene ID: ENSMUSG00000027577
  
Biological name :Chrna4
  
Synonyms : cholinergic receptor, nicotinic, alpha polypeptide 4 / Chrna4 / O70174
  
Possible biological names infered from orthology : cholinergic receptor nicotinic alpha 4 subunit / P43681
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H4
Gene start: 181018380
Gene end: 181043546
  
Corresponding Affymetrix probe sets: 10490559 (MoGene1.0st)   1421202_at (Mouse Genome 430 2.0 Array)   1421203_at (Mouse Genome 430 2.0 Array)   1456354_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066338
Ensembl peptide - ENSMUSP00000143253
Ensembl peptide - ENSMUSP00000123043
Ensembl peptide - ENSMUSP00000104479
NCBI entrez gene - 11438     See in Manteia.
MGI - MGI:87888
RefSeq - XM_006500551
RefSeq - NM_015730
RefSeq Peptide - NP_056545
swissprot - B7ZBU7
swissprot - B7ZBV1
swissprot - O70174
swissprot - Q53YK0
swissprot - A0A0G2JFP3
Ensembl - ENSMUSG00000027577
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrna4aENSDARG00000087071Danio rerio
 chrna4bENSDARG00000070724Danio rerio
 CHRNA4ENSGALG00000005801Gallus gallus
 CHRNA4ENSG00000101204Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chrna2 / Q91X60 / cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) / Q15822* / cholinergic receptor nicotinic alpha 2 subunit*ENSMUSG0000002204153
Chrna3 / cholinergic receptor, nicotinic, alpha polypeptide 3 / P32297* / cholinergic receptor nicotinic alpha 3 subunit*ENSMUSG0000003230345
Chrna6 / Q9R0W9 / cholinergic receptor, nicotinic, alpha polypeptide 6 / Q15825* / cholinergic receptor nicotinic alpha 6 subunit*ENSMUSG0000003149142
Chrnb2 / Q9ERK7 / cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) / P17787* / cholinergic receptor nicotinic beta 2 subunit*ENSMUSG0000002795039
Chrnb4 / Q8R493 / cholinergic receptor, nicotinic, beta polypeptide 4 / P30926* / cholinergic receptor nicotinic beta 4 subunit*ENSMUSG0000003520038
Chrnb3 / Q8BMN3 / cholinergic receptor, nicotinic, beta polypeptide 3 / Q05901* / cholinergic receptor nicotinic beta 3 subunit*ENSMUSG0000003149237
Chrna1 / P04756 / cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) / P02708* / cholinergic receptor nicotinic alpha 1 subunit*ENSMUSG0000002710736
Chrna5 / Q2MKA5 / cholinergic receptor, nicotinic, alpha polypeptide 5 / P30532* / cholinergic receptor nicotinic alpha 5 subunit*ENSMUSG0000003559436


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001508 action potential IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IGI
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007271 synaptic transmission, cholinergic IMP
 biological_processGO:0007274 neuromuscular synaptic transmission IBA
 biological_processGO:0007585 respiratory gaseous exchange IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0014059 regulation of dopamine secretion IMP
 biological_processGO:0019233 sensory perception of pain TAS
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035095 behavioral response to nicotine IEA
 biological_processGO:0035640 exploration behavior IMP
 biological_processGO:0042113 B cell activation IMP
 biological_processGO:0042391 regulation of membrane potential IGI
 biological_processGO:0050877 nervous system process IEA
 biological_processGO:0050890 cognition IEA
 biological_processGO:0051899 membrane depolarization IMP
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060080 inhibitory postsynaptic potential IMP
 biological_processGO:0095500 acetylcholine receptor signaling pathway IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005892 acetylcholine-gated channel complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015464 acetylcholine receptor activity IEA
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity TAS
 molecular_functionGO:0042166 acetylcholine binding IBA


Pathways (from Reactome)
Pathway description
Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

Allelic Composition: Chrna4tm1Lst/Chrna4+
Genetic Background: involves: C57BL/6

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Chrna4tm1Lst/Chrna4+
Genetic Background: involves: C57BL/6

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rdh12tm1.1Cahb/Rdh12tm1.1Cahb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chrna4tm1Jbou/Chrna4tm1Jbou
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

Allelic Composition: Chrna4tm2Jbou/Chrna4+
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

Allelic Composition: Chrna4tm2Jbou/Chrna4tm2Jbou
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Chrna4tm1Lst/Chrna4+
Genetic Background: involves: C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Rdh12tm1.1Cahb/Rdh12tm1.1Cahb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Rdh12tm1.1Cahb/Rdh12tm1.1Cahb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chrna4tm1Jbou/Chrna4tm1Jbou
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

Allelic Composition: Chrna4tm2Jbou/Chrna4+
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

Allelic Composition: Chrna4tm2Jbou/Chrna4tm2Jbou
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv

 MP:0003996 clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by unilateral or bilateral rhythmic jerking movements of the arms and legs caused by alternating contraction and relaxation of muscle" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rdh12tm1.1Cahb/Rdh12tm1.1Cahb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Chrna4tm1Jbou/Chrna4tm1Jbou
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

Allelic Composition: Chrna4tm2Jbou/Chrna4+
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

Allelic Composition: Chrna4tm2Jbou/Chrna4tm2Jbou
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

Allelic Composition: Chrna4tm1Jbou/Chrna4+
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

Allelic Composition: Chrna4tm1Jbou/Chrna4tm1Jbou
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

Allelic Composition: Chrna4tm2Jbou/Chrna4+
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

Allelic Composition: Chrna4tm2Jbou/Chrna4tm2Jbou
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lbric-J/Lbrlym3
Genetic Background: C57BL/6-Lbric-J/Lbrlym3

 MP:0008035 behavioral arrest "locomotor activity is interrupted by sudden periods of no movement" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Chrna4tm1Jbou/Chrna4+
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

Allelic Composition: Chrna4tm1Jbou/Chrna4tm1Jbou
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

Allelic Composition: Chrna4tm2Jbou/Chrna4+
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

Allelic Composition: Chrna4tm2Jbou/Chrna4tm2Jbou
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

 MP:0009475 abnormal nicotine-mediated receptor currents "change in the measured amplitude, current density or duration of response to stimulation of nicotinic receptors" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hcsttm1.1Dnax/Hcsttm1.1Dnax
Genetic Background: involves: C57BL/6

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chrna4tm1.1Tmcg/Chrna4tm1.1Tmcg,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

Allelic Composition: Chrna4tm1.2Tmcg/Chrna4tm1.2Tmcg
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

Allelic Composition: Chrna4tm1.1Stit/Chrna4tm1.1Stit
Genetic Background: B6.129X1-Chrna4tm1.1Stit

 MP:0009713 enhanced conditioned place preference behavior "increase in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0009748 abnormal behavioral response to addictive substance "any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp5se/Bmp5se
Genetic Background: Not Specified

Allelic Composition: Chrna4tm2Dra/Chrna4+
Genetic Background: involves: 129S1/Sv * CD-1

Allelic Composition: Chrna4tm2.1Dra/Chrna4+
Genetic Background: involves: 129S1/Sv * CD-1

Allelic Composition: Chrna4tm2.1Dra/Chrna4+
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

Allelic Composition: Chrna4tm2.1Dra/Chrna4+
Genetic Background: B6.129S1-Chrna4tm2.1Dra

Allelic Composition: Chrna4tm1.1Stit/Chrna4tm1.1Stit
Genetic Background: B6.129X1-Chrna4tm1.1Stit

 MP:0009750 impaired behavioral response to addictive substance "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chrna4tm1Lst/Chrna4+
Genetic Background: involves: C57BL/6

 MP:0009752 enhanced behavioral response to nicotine "increased sensitivity to nicotine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Chrna4tm1Lst/Chrna4+
Genetic Background: involves: C57BL/6

Allelic Composition: Chrna4tm1.1Tmcg/Chrna4tm1.1Tmcg,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

 MP:0009756 impaired behavioral response to nicotine "decreased sensitivity to nicotine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chrna4tm2.1Dra/Chrna4+
Genetic Background: involves: 129S1/Sv * CD-1

Allelic Composition: Chrna4tm2.1Dra/Chrna4+
Genetic Background: involves: 129S1/Sv * C57BL/6 * CD-1

Allelic Composition: Chrna4tm2.1Dra/Chrna4+
Genetic Background: B6.129S1-Chrna4tm2.1Dra

Allelic Composition: Chrna4tm1.1Tmcg/Chrna4tm1.1Tmcg,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

Allelic Composition: Chrna4tm1.2Tmcg/Chrna4tm1.2Tmcg
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

 MP:0010149 abnormal synaptic dopamine release "aberrant secretion across synapses of the catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chrna4tm1.1Tmcg/Chrna4tm1.1Tmcg,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

Allelic Composition: Chrna4tm1.2Tmcg/Chrna4tm1.2Tmcg
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cdx2tm1.1Lhn/Cdx2+,Tg(CAG-cre/ERT2)F34Fmr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011448 decreased dopaminergic neuron number "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]
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Allelic Composition: Cdx2tm1.1Lhn/Cdx2+,Tg(CAG-cre/ERT2)F34Fmr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031491 Chrna6 / Q9R0W9 / cholinergic receptor, nicotinic, alpha polypeptide 6 / Q15825* / cholinergic receptor nicotinic alpha 6 subunit*  / complex
 ENSMUSG00000027950 Chrnb2 / Q9ERK7 / cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) / P17787* / cholinergic receptor nicotinic beta 2 subunit*  / complex
 ENSMUSG00000031492 Chrnb3 / Q8BMN3 / cholinergic receptor, nicotinic, beta polypeptide 3 / Q05901* / cholinergic receptor nicotinic beta 3 subunit*  / complex
 ENSMUSG00000027577 Chrna4 / O70174 / cholinergic receptor, nicotinic, alpha polypeptide 4 / P43681* / cholinergic receptor nicotinic alpha 4 subunit*  / complex






 

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