ENSMUSG00000035200


Mus musculus

Features
Gene ID: ENSMUSG00000035200
  
Biological name :Chrnb4
  
Synonyms : cholinergic receptor, nicotinic, beta polypeptide 4 / Chrnb4 / Q8R493
  
Possible biological names infered from orthology : cholinergic receptor nicotinic beta 4 subunit / P30926
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 55028154
Gene end: 55048779
  
Corresponding Affymetrix probe sets: 10593767 (MoGene1.0st)   1425849_at (Mouse Genome 430 2.0 Array)   1457008_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034854
NCBI entrez gene - 108015     See in Manteia.
MGI - MGI:87892
RefSeq - XM_011242655
RefSeq - NM_148944
RefSeq - XM_006510757
RefSeq Peptide - NP_683746
swissprot - Q8R493
swissprot - Q3USV2
Ensembl - ENSMUSG00000035200
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrnb4ENSDARG00000101677Danio rerio
 CHRNB4ENSGALG00000003005Gallus gallus
 CHRNB4ENSG00000117971Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chrnb2 / Q9ERK7 / cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) / P17787* / cholinergic receptor nicotinic beta 2 subunit*ENSMUSG0000002795061
Chrna4 / O70174 / cholinergic receptor, nicotinic, alpha polypeptide 4 / P43681* / cholinergic receptor nicotinic alpha 4 subunit*ENSMUSG0000002757748
Chrna2 / Q91X60 / cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) / Q15822* / cholinergic receptor nicotinic alpha 2 subunit*ENSMUSG0000002204146
Chrna3 / cholinergic receptor, nicotinic, alpha polypeptide 3 / P32297* / cholinergic receptor nicotinic alpha 3 subunit*ENSMUSG0000003230344
Chrna6 / Q9R0W9 / cholinergic receptor, nicotinic, alpha polypeptide 6 / Q15825* / cholinergic receptor nicotinic alpha 6 subunit*ENSMUSG0000003149142
Chrna5 / Q2MKA5 / cholinergic receptor, nicotinic, alpha polypeptide 5 / P30532* / cholinergic receptor nicotinic alpha 5 subunit*ENSMUSG0000003559439
Chrnb3 / Q8BMN3 / cholinergic receptor, nicotinic, beta polypeptide 3 / Q05901* / cholinergic receptor nicotinic beta 3 subunit*ENSMUSG0000003149238
Chrna1 / P04756 / cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) / P02708* / cholinergic receptor nicotinic alpha 1 subunit*ENSMUSG0000002710737


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001508 action potential IGI
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006939 smooth muscle contraction IGI
 biological_processGO:0006940 regulation of smooth muscle contraction IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007271 synaptic transmission, cholinergic IBA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035094 response to nicotine IGI
 biological_processGO:0035095 behavioral response to nicotine IMP
 biological_processGO:0042391 regulation of membrane potential IGI
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051971 positive regulation of transmission of nerve impulse IMP
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060084 synaptic transmission involved in micturition ISO
 biological_processGO:0098655 cation transmembrane transport IBA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005892 acetylcholine-gated channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0015464 acetylcholine receptor activity IEA
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity IBA
 molecular_functionGO:0042166 acetylcholine binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000054 delayed ear emergence "late onset of the growth of the outer ear" [J:49421]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0000422 delayed hair appearance "late onset of the first appearance of the fur" [J:17792]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0000538 abnormal urinary bladder morphology "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0000539 distended urinary bladder "stretched musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0000540 abnormal urinary bladder epithelium morphology "malformation of the epithelial layer of the urinary bladder" [MGI:tc]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0002546 mydriasis "dilation of one or both pupils" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
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Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: Chrna5tm1Mdb/Chrna5tm1Mdb,Chrnb4tm1Mdb/Chrnb4tm1Mdb
Genetic Background: B6.129-Chrnb4tm1Mdb Chrna5tm1Mdb

 MP:0003280 urinary incontinence "inability to control the urinary excretory functions" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0003290 hypoperistalsis "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0005176 eyelids fail to open "eyes remain shut throughout life" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0006243 abnormal pupil dilation reaction to light "the pupil fails to constrict fully when exposed to bright light" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0006276 abnormal autonomic nervous system physiology "anomaly in the function of the sensory and motor neurons that run between the central nervous system (especially the hypothalamus and medulla oblongata) and various internal organs (heart, lungs, endocrine and exocrine glands), responsible for controling involuntary bodily functions" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0009646 urinary bladder inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the urinary bladder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0010386 abnormal urinary bladder physiology "any functional anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Chrnb2tm1Mdb/Chrnb2tm1Mdb,Chrnb4tm1Mdb/Chrnb4tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Chrnb2tm1Mdb/Chrnb2tm1Mdb,Chrnb4tm1Mdb/Chrnb4tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011625 cystolithiasis "caliculi, or a solid concretion or crystal aggregation, found in the urinary bladder; often embedded in a glycoprotein matrix which may also contain some nonglycoproteins when associated with infection" [MGI:csmith]
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Allelic Composition: Chrnb2tm1Mdb/Chrnb2tm1Mdb,Chrnb4tm1Mdb/Chrnb4tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031491 Chrna6 / Q9R0W9 / cholinergic receptor, nicotinic, alpha polypeptide 6 / Q15825* / cholinergic receptor nicotinic alpha 6 subunit*  / complex
 ENSMUSG00000014609 Chrne / P20782 / cholinergic receptor, nicotinic, epsilon polypeptide / Q04844* / cholinergic receptor nicotinic epsilon subunit*  / complex
 ENSMUSG00000031492 Chrnb3 / Q8BMN3 / cholinergic receptor, nicotinic, beta polypeptide 3 / Q05901* / cholinergic receptor nicotinic beta 3 subunit*  / complex
 ENSMUSG00000026253 Chrng / cholinergic receptor, nicotinic, gamma polypeptide / P07510* / cholinergic receptor nicotinic gamma subunit*  / complex
 ENSMUSG00000026251 Chrnd / P02716 / cholinergic receptor, nicotinic, delta polypeptide / Q07001* / cholinergic receptor nicotinic delta subunit*  / complex
 ENSMUSG00000032303 Chrna3 / cholinergic receptor, nicotinic, alpha polypeptide 3 / P32297* / cholinergic receptor nicotinic alpha 3 subunit*  / complex
 ENSMUSG00000035200 Chrnb4 / Q8R493 / cholinergic receptor, nicotinic, beta polypeptide 4 / P30926* / cholinergic receptor nicotinic beta 4 subunit*  / complex
 ENSMUSG00000035594 Chrna5 / Q2MKA5 / cholinergic receptor, nicotinic, alpha polypeptide 5 / P30532* / cholinergic receptor nicotinic alpha 5 subunit*  / complex






 

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