ENSMUSG00000032303


Mus musculus

Features
Gene ID: ENSMUSG00000032303
  
Biological name :Chrna3
  
Synonyms : cholinergic receptor, nicotinic, alpha polypeptide 3 / Chrna3
  
Possible biological names infered from orthology : cholinergic receptor nicotinic alpha 3 subunit / P32297
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 55010111
Gene end: 55026562
  
Corresponding Affymetrix probe sets: 10593756 (MoGene1.0st)   1444368_at (Mouse Genome 430 2.0 Array)   1452010_at (Mouse Genome 430 2.0 Array)   1455931_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150636
Ensembl peptide - ENSMUSP00000034851
NCBI entrez gene - 110834     See in Manteia.
MGI - MGI:87887
RefSeq - NM_145129
RefSeq Peptide - NP_660111
swissprot - A0A1L1SU72
swissprot - Q0VBK4
Ensembl - ENSMUSG00000032303
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrna3ENSDARG00000100991Danio rerio
 CHRNA3ENSGALG00000003014Gallus gallus
 CHRNA3ENSG00000080644Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chrna6 / Q9R0W9 / cholinergic receptor, nicotinic, alpha polypeptide 6 / Q15825* / cholinergic receptor nicotinic alpha 6 subunit*ENSMUSG0000003149160
Chrna4 / O70174 / cholinergic receptor, nicotinic, alpha polypeptide 4 / P43681* / cholinergic receptor nicotinic alpha 4 subunit*ENSMUSG0000002757756
Chrna2 / Q91X60 / cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) / Q15822* / cholinergic receptor nicotinic alpha 2 subunit*ENSMUSG0000002204155
Chrnb2 / Q9ERK7 / cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) / P17787* / cholinergic receptor nicotinic beta 2 subunit*ENSMUSG0000002795045
Chrna1 / P04756 / cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) / P02708* / cholinergic receptor nicotinic alpha 1 subunit*ENSMUSG0000002710745
Chrnb4 / Q8R493 / cholinergic receptor, nicotinic, beta polypeptide 4 / P30926* / cholinergic receptor nicotinic beta 4 subunit*ENSMUSG0000003520043
Chrnb3 / Q8BMN3 / cholinergic receptor, nicotinic, beta polypeptide 3 / Q05901* / cholinergic receptor nicotinic beta 3 subunit*ENSMUSG0000003149243
Chrna5 / Q2MKA5 / cholinergic receptor, nicotinic, alpha polypeptide 5 / P30532* / cholinergic receptor nicotinic alpha 5 subunit*ENSMUSG0000003559442


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035095 behavioral response to nicotine IEA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060084 synaptic transmission involved in micturition IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005892 acetylcholine-gated channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0015464 acetylcholine receptor activity IEA
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity IEA


Pathways (from Reactome)
Pathway description
Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Chrna3tm1.1Hwrt/Chrna3tm1.1Hwrt
Genetic Background: B6.129S7-Chrna3tm1.1Hwrt

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000539 distended urinary bladder "stretched musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Chrna3tm1.1Hwrt/Chrna3tm1.1Hwrt
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * ICR

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Chrna3tm1.1Hwrt/Chrna3tm1.1Hwrt
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * BALB/c * C57BL/6

Allelic Composition: Chrna3tm1.1Hwrt/Chrna3tm1.1Hwrt
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * CD-1

Allelic Composition: Chrna3tm1.1Hwrt/Chrna3tm1.1Hwrt
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * ICR

Allelic Composition: Chrna3tm1.1Hwrt/Chrna3tm1.1Hwrt
Genetic Background: B6.129S7-Chrna3tm1.1Hwrt

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002546 mydriasis "dilation of one or both pupils" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Irf3tm1Ttg/Irf3tm1Ttg,Irf7tm1Ttg/Irf7tm1Ttg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Chrna3tm1.1Hwrt/Chrna3tm1.1Hwrt
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0003197 kidney calcification "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003280 urinary incontinence "inability to control the urinary excretory functions" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003619 abnormal urine color "any alteration from the usual straw-coloration of the urine" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005176 eyelids fail to open "eyes remain shut throughout life" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chrna3tm1.1Hwrt/Chrna3tm1.1Hwrt
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * CD-1

 MP:0006243 abnormal pupil dilation reaction to light "the pupil fails to constrict fully when exposed to bright light" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006276 abnormal autonomic nervous system physiology "anomaly in the function of the sensory and motor neurons that run between the central nervous system (especially the hypothalamus and medulla oblongata) and various internal organs (heart, lungs, endocrine and exocrine glands), responsible for controling involuntary bodily functions" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009511 distended stomach "an expansion in the volume of the sac-like structure of the digestive canal between the esophagus and the small intestine, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009646 urinary bladder inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the urinary bladder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010386 abnormal urinary bladder physiology "any functional anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Chrna3tm1.1Hwrt/Chrna3tm1.1Hwrt
Genetic Background: B6.129S7-Chrna3tm1.1Hwrt

 MP:0011625 cystolithiasis "caliculi, or a solid concretion or crystal aggregation, found in the urinary bladder; often embedded in a glycoprotein matrix which may also contain some nonglycoproteins when associated with infection" [MGI:csmith]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011766 abnormal urinary bladder mucosa morphology "any structural anomaly of the mucous membrane lining the urinary bladder" [MGI:anna]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014609 Chrne / P20782 / cholinergic receptor, nicotinic, epsilon polypeptide / Q04844* / cholinergic receptor nicotinic epsilon subunit*  / complex
 ENSMUSG00000026253 Chrng / cholinergic receptor, nicotinic, gamma polypeptide / P07510* / cholinergic receptor nicotinic gamma subunit*  / complex
 ENSMUSG00000032303 Chrna3 / cholinergic receptor, nicotinic, alpha polypeptide 3 / P32297* / cholinergic receptor nicotinic alpha 3 subunit*  / complex
 ENSMUSG00000035200 Chrnb4 / Q8R493 / cholinergic receptor, nicotinic, beta polypeptide 4 / P30926* / cholinergic receptor nicotinic beta 4 subunit*  / complex
 ENSMUSG00000027950 Chrnb2 / Q9ERK7 / cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) / P17787* / cholinergic receptor nicotinic beta 2 subunit*  / complex
 ENSMUSG00000026251 Chrnd / P02716 / cholinergic receptor, nicotinic, delta polypeptide / Q07001* / cholinergic receptor nicotinic delta subunit*  / complex
 ENSMUSG00000035594 Chrna5 / Q2MKA5 / cholinergic receptor, nicotinic, alpha polypeptide 5 / P30532* / cholinergic receptor nicotinic alpha 5 subunit*  / complex






 

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