ENSG00000080644


Homo sapiens

Features
Gene ID: ENSG00000080644
  
Biological name :CHRNA3
  
Synonyms : cholinergic receptor nicotinic alpha 3 subunit / CHRNA3 / P32297
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q25.1
Gene start: 78593052
Gene end: 78621295
  
Corresponding Affymetrix probe sets: 210221_at (Human Genome U133 Plus 2.0 Array)   211587_x_at (Human Genome U133 Plus 2.0 Array)   211772_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000267951
Ensembl peptide - ENSP00000315602
Ensembl peptide - ENSP00000452896
Ensembl peptide - ENSP00000453993
NCBI entrez gene - 1136     See in Manteia.
OMIM - 118503
RefSeq - XM_006720382
RefSeq - NM_000743
RefSeq - NM_001166694
RefSeq Peptide - NP_000734
RefSeq Peptide - NP_001160166
swissprot - P32297
swissprot - H0YNF9
Ensembl - ENSG00000080644
  
Related genetic diseases (OMIM): 612052 - {Lung cancer susceptibility 2}, 612052
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrna3ENSDARG00000100991Danio rerio
 CHRNA3ENSGALG00000003014Gallus gallus
 Chrna3ENSMUSG00000032303Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHRNA6 / Q15825 / cholinergic receptor nicotinic alpha 6 subunitENSG0000014743463
CHRNA4 / P43681 / cholinergic receptor nicotinic alpha 4 subunitENSG0000010120457
CHRNA2 / Q15822 / cholinergic receptor nicotinic alpha 2 subunitENSG0000012090355
CHRNA1 / P02708 / cholinergic receptor nicotinic alpha 1 subunitENSG0000013843545
CHRNB2 / P17787 / cholinergic receptor nicotinic beta 2 subunitENSG0000016071644
CHRNB4 / P30926 / cholinergic receptor nicotinic beta 4 subunitENSG0000011797144
CHRNB3 / Q05901 / cholinergic receptor nicotinic beta 3 subunitENSG0000014743243
CHRNA5 / P30532 / cholinergic receptor nicotinic alpha 5 subunitENSG0000016968442


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport NAS
 biological_processGO:0006940 regulation of smooth muscle contraction ISS
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity ISS
 biological_processGO:0007271 synaptic transmission, cholinergic ISS
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007626 locomotory behavior ISS
 biological_processGO:0014056 regulation of acetylcholine secretion, neurotransmission ISS
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035095 behavioral response to nicotine IMP
 biological_processGO:0042391 regulation of membrane potential ISS
 biological_processGO:0048814 regulation of dendrite morphogenesis ISS
 biological_processGO:0060079 excitatory postsynaptic potential ISS
 biological_processGO:0060084 synaptic transmission involved in micturition IMP
 biological_processGO:0095500 acetylcholine receptor signaling pathway ISS
 biological_processGO:0098655 cation transmembrane transport IEA
 biological_processGO:1905144 response to acetylcholine ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005892 acetylcholine-gated channel complex IDA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0044853 plasma membrane raft ISS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015276 ligand-gated ion channel activity TAS
 molecular_functionGO:0015464 acetylcholine receptor activity IDA
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity TAS
 molecular_functionGO:0022850 serotonin-gated cation-selective channel activity IBA
 molecular_functionGO:0042166 acetylcholine binding IC


Pathways (from Reactome)
Pathway description
Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135902 CHRND / Q07001 / cholinergic receptor nicotinic delta subunit  / complex
 ENSG00000108556 CHRNE / Q04844 / cholinergic receptor nicotinic epsilon subunit  / complex
 ENSG00000169684 CHRNA5 / P30532 / cholinergic receptor nicotinic alpha 5 subunit  / complex
 ENSG00000117971 CHRNB4 / P30926 / cholinergic receptor nicotinic beta 4 subunit  / complex
 ENSG00000080644 CHRNA3 / P32297 / cholinergic receptor nicotinic alpha 3 subunit  / complex
 ENSG00000160716 CHRNB2 / P17787 / cholinergic receptor nicotinic beta 2 subunit  / complex
 ENSG00000196811 CHRNG / P07510 / cholinergic receptor nicotinic gamma subunit  / complex






 

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