ENSG00000147434


Homo sapiens

Features
Gene ID: ENSG00000147434
  
Biological name :CHRNA6
  
Synonyms : cholinergic receptor nicotinic alpha 6 subunit / CHRNA6 / Q15825
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p11.21
Gene start: 42752620
Gene end: 42796392
  
Corresponding Affymetrix probe sets: 207568_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433871
Ensembl peptide - ENSP00000434659
Ensembl peptide - ENSP00000276410
NCBI entrez gene - 8973     See in Manteia.
OMIM - 606888
RefSeq - NM_001199279
RefSeq - NM_004198
RefSeq Peptide - NP_001186208
RefSeq Peptide - NP_004189
swissprot - E9PP97
swissprot - Q15825
Ensembl - ENSG00000147434
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrna6ENSDARG00000055559Danio rerio
 CHRNA6ENSGALG00000015382Gallus gallus
 Chrna6ENSMUSG00000031491Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHRNA3 / P32297 / cholinergic receptor nicotinic alpha 3 subunitENSG0000008064464
CHRNA4 / P43681 / cholinergic receptor nicotinic alpha 4 subunitENSG0000010120454
CHRNA2 / Q15822 / cholinergic receptor nicotinic alpha 2 subunitENSG0000012090351
CHRNB2 / P17787 / cholinergic receptor nicotinic beta 2 subunitENSG0000016071645
CHRNB3 / Q05901 / cholinergic receptor nicotinic beta 3 subunitENSG0000014743244
CHRNA1 / P02708 / cholinergic receptor nicotinic alpha 1 subunitENSG0000013843543
CHRNA5 / P30532 / cholinergic receptor nicotinic alpha 5 subunitENSG0000016968443
CHRNB4 / P30926 / cholinergic receptor nicotinic beta 4 subunitENSG0000011797142


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007271 synaptic transmission, cholinergic IBA
 biological_processGO:0007274 neuromuscular synaptic transmission IBA
 biological_processGO:0014059 regulation of dopamine secretion IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035094 response to nicotine IBA
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0098655 cation transmembrane transport IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005892 acetylcholine-gated channel complex TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015276 ligand-gated ion channel activity TAS
 molecular_functionGO:0015464 acetylcholine receptor activity TAS
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity IEA
 molecular_functionGO:0042166 acetylcholine binding IBA


Pathways (from Reactome)
Pathway description
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000117971 CHRNB4 / P30926 / cholinergic receptor nicotinic beta 4 subunit  / complex
 ENSG00000147432 CHRNB3 / Q05901 / cholinergic receptor nicotinic beta 3 subunit  / complex
 ENSG00000101204 CHRNA4 / P43681 / cholinergic receptor nicotinic alpha 4 subunit  / complex






 

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