ENSG00000147432


Homo sapiens

Features
Gene ID: ENSG00000147432
  
Biological name :CHRNB3
  
Synonyms : cholinergic receptor nicotinic beta 3 subunit / CHRNB3 / Q05901
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p11.21
Gene start: 42697376
Gene end: 42737407
  
Corresponding Affymetrix probe sets: 207859_s_at (Human Genome U133 Plus 2.0 Array)   217086_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000289957
Ensembl peptide - ENSP00000433913
NCBI entrez gene - 1142     See in Manteia.
OMIM - 118508
RefSeq - NM_000749
RefSeq Peptide - NP_000740
swissprot - A0A1D5RMT8
swissprot - Q05901
Ensembl - ENSG00000147432
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrnb3aENSDARG00000052764Danio rerio
 chrnb3bENSDARG00000038508Danio rerio
 CHRNB3ENSGALG00000015384Gallus gallus
 Chrnb3ENSMUSG00000031492Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHRNA5 / P30532 / cholinergic receptor nicotinic alpha 5 subunitENSG0000016968465
CHRNA2 / Q15822 / cholinergic receptor nicotinic alpha 2 subunitENSG0000012090353
CHRNA4 / P43681 / cholinergic receptor nicotinic alpha 4 subunitENSG0000010120453
CHRNA6 / Q15825 / cholinergic receptor nicotinic alpha 6 subunitENSG0000014743447
CHRNA3 / P32297 / cholinergic receptor nicotinic alpha 3 subunitENSG0000008064447
CHRNB4 / P30926 / cholinergic receptor nicotinic beta 4 subunitENSG0000011797142
CHRNB2 / P17787 / cholinergic receptor nicotinic beta 2 subunitENSG0000016071641
CHRNA1 / P02708 / cholinergic receptor nicotinic alpha 1 subunitENSG0000013843541


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007271 synaptic transmission, cholinergic TAS
 biological_processGO:0007274 neuromuscular synaptic transmission IBA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035094 response to nicotine IBA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0098655 cation transmembrane transport IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005892 acetylcholine-gated channel complex TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0015267 channel activity TAS
 molecular_functionGO:0015276 ligand-gated ion channel activity TAS
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity IBA
 molecular_functionGO:0042166 acetylcholine binding IBA


Pathways (from Reactome)
Pathway description
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000147432 CHRNB3 / Q05901 / cholinergic receptor nicotinic beta 3 subunit  / complex
 ENSG00000147434 CHRNA6 / Q15825 / cholinergic receptor nicotinic alpha 6 subunit  / complex
 ENSG00000120903 CHRNA2 / Q15822 / cholinergic receptor nicotinic alpha 2 subunit  / complex
 ENSG00000101204 CHRNA4 / P43681 / cholinergic receptor nicotinic alpha 4 subunit  / complex
 ENSG00000117971 CHRNB4 / P30926 / cholinergic receptor nicotinic beta 4 subunit  / complex






 

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