ENSG00000117971


Homo sapiens

Features
Gene ID: ENSG00000117971
  
Biological name :CHRNB4
  
Synonyms : cholinergic receptor nicotinic beta 4 subunit / CHRNB4 / P30926
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q25.1
Gene start: 78624119
Gene end: 78727754
  
Corresponding Affymetrix probe sets: 207516_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261751
Ensembl peptide - ENSP00000416386
Ensembl peptide - ENSP00000457404
NCBI entrez gene - 1143     See in Manteia.
OMIM - 118509
RefSeq - XM_017021889
RefSeq - NM_000750
RefSeq - NM_001256567
RefSeq - XM_017021885
RefSeq - XM_017021886
RefSeq - XM_017021887
RefSeq - XM_017021888
RefSeq - XM_011521186
RefSeq - XM_011521187
RefSeq - XM_011521190
RefSeq - XM_011521191
RefSeq - XM_011521192
RefSeq Peptide - NP_000741
RefSeq Peptide - NP_001243496
swissprot - P30926
swissprot - H3BU02
Ensembl - ENSG00000117971
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrnb4ENSDARG00000101677Danio rerio
 CHRNB4ENSGALG00000003005Gallus gallus
 Chrnb4ENSMUSG00000035200Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHRNB2 / P17787 / cholinergic receptor nicotinic beta 2 subunitENSG0000016071663
CHRNA4 / P43681 / cholinergic receptor nicotinic alpha 4 subunitENSG0000010120448
CHRNA2 / Q15822 / cholinergic receptor nicotinic alpha 2 subunitENSG0000012090346
CHRNA3 / P32297 / cholinergic receptor nicotinic alpha 3 subunitENSG0000008064445
CHRNA6 / Q15825 / cholinergic receptor nicotinic alpha 6 subunitENSG0000014743442
CHRNA5 / P30532 / cholinergic receptor nicotinic alpha 5 subunitENSG0000016968438
CHRNB3 / Q05901 / cholinergic receptor nicotinic beta 3 subunitENSG0000014743238
CHRNA1 / P02708 / cholinergic receptor nicotinic alpha 1 subunitENSG0000013843537


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001508 action potential IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006939 smooth muscle contraction IEA
 biological_processGO:0006940 regulation of smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007271 synaptic transmission, cholinergic TAS
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035094 response to nicotine IBA
 biological_processGO:0035095 behavioral response to nicotine IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0046928 regulation of neurotransmitter secretion NAS
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051971 positive regulation of transmission of nerve impulse IEA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060084 synaptic transmission involved in micturition IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IC
 cellular_componentGO:0005892 acetylcholine-gated channel complex TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0015276 ligand-gated ion channel activity TAS
 molecular_functionGO:0015464 acetylcholine receptor activity IDA
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity TAS
 molecular_functionGO:0042166 acetylcholine binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135902 CHRND / Q07001 / cholinergic receptor nicotinic delta subunit  / complex
 ENSG00000147434 CHRNA6 / Q15825 / cholinergic receptor nicotinic alpha 6 subunit  / complex
 ENSG00000117971 CHRNB4 / P30926 / cholinergic receptor nicotinic beta 4 subunit  / complex
 ENSG00000108556 CHRNE / Q04844 / cholinergic receptor nicotinic epsilon subunit  / complex
 ENSG00000147432 CHRNB3 / Q05901 / cholinergic receptor nicotinic beta 3 subunit  / complex
 ENSG00000169684 CHRNA5 / P30532 / cholinergic receptor nicotinic alpha 5 subunit  / complex
 ENSG00000080644 CHRNA3 / P32297 / cholinergic receptor nicotinic alpha 3 subunit  / complex
 ENSG00000196811 CHRNG / P07510 / cholinergic receptor nicotinic gamma subunit  / complex






 

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