ENSMUSG00000031491


Mus musculus

Features
Gene ID: ENSMUSG00000031491
  
Biological name :Chrna6
  
Synonyms : cholinergic receptor, nicotinic, alpha polypeptide 6 / Chrna6 / Q9R0W9
  
Possible biological names infered from orthology : cholinergic receptor nicotinic alpha 6 subunit / Q15825
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 27403212
Gene end: 27413944
  
Corresponding Affymetrix probe sets: 10577980 (MoGene1.0st)   1450426_at (Mouse Genome 430 2.0 Array)   1450427_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033882
NCBI entrez gene - 11440     See in Manteia.
MGI - MGI:106213
RefSeq - NM_021369
RefSeq Peptide - NP_067344
swissprot - Q9R0W9
Ensembl - ENSMUSG00000031491
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrna6ENSDARG00000055559Danio rerio
 CHRNA6ENSGALG00000015382Gallus gallus
 CHRNA6ENSG00000147434Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chrna3 / cholinergic receptor, nicotinic, alpha polypeptide 3 / P32297* / cholinergic receptor nicotinic alpha 3 subunit*ENSMUSG0000003230361
Chrna4 / O70174 / cholinergic receptor, nicotinic, alpha polypeptide 4 / P43681* / cholinergic receptor nicotinic alpha 4 subunit*ENSMUSG0000002757754
Chrna2 / Q91X60 / cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) / Q15822* / cholinergic receptor nicotinic alpha 2 subunit*ENSMUSG0000002204152
Chrna5 / Q2MKA5 / cholinergic receptor, nicotinic, alpha polypeptide 5 / P30532* / cholinergic receptor nicotinic alpha 5 subunit*ENSMUSG0000003559443
Chrnb4 / Q8R493 / cholinergic receptor, nicotinic, beta polypeptide 4 / P30926* / cholinergic receptor nicotinic beta 4 subunit*ENSMUSG0000003520043
Chrnb2 / Q9ERK7 / cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) / P17787* / cholinergic receptor nicotinic beta 2 subunit*ENSMUSG0000002795043
Chrnb3 / Q8BMN3 / cholinergic receptor, nicotinic, beta polypeptide 3 / Q05901* / cholinergic receptor nicotinic beta 3 subunit*ENSMUSG0000003149243
Chrna1 / P04756 / cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) / P02708* / cholinergic receptor nicotinic alpha 1 subunit*ENSMUSG0000002710742


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007271 synaptic transmission, cholinergic IBA
 biological_processGO:0007274 neuromuscular synaptic transmission IBA
 biological_processGO:0014059 regulation of dopamine secretion IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035094 response to nicotine IBA
 biological_processGO:0051899 membrane depolarization IMP
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005892 acetylcholine-gated channel complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity IMP
 molecular_functionGO:0042166 acetylcholine binding IBA


Pathways (from Reactome)
Pathway description
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027577 Chrna4 / O70174 / cholinergic receptor, nicotinic, alpha polypeptide 4 / P43681* / cholinergic receptor nicotinic alpha 4 subunit*  / complex
 ENSMUSG00000031492 Chrnb3 / Q8BMN3 / cholinergic receptor, nicotinic, beta polypeptide 3 / Q05901* / cholinergic receptor nicotinic beta 3 subunit*  / complex
 ENSMUSG00000035200 Chrnb4 / Q8R493 / cholinergic receptor, nicotinic, beta polypeptide 4 / P30926* / cholinergic receptor nicotinic beta 4 subunit*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr