ENSMUSG00000027950


Mus musculus

Features
Gene ID: ENSMUSG00000027950
  
Biological name :Chrnb2
  
Synonyms : cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) / Chrnb2 / Q9ERK7
  
Possible biological names infered from orthology : cholinergic receptor nicotinic beta 2 subunit / P17787
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 89746195
Gene end: 89764632
  
Corresponding Affymetrix probe sets: 10499643 (MoGene1.0st)   1420744_at (Mouse Genome 430 2.0 Array)   1436428_at (Mouse Genome 430 2.0 Array)   1441837_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143441
Ensembl peptide - ENSMUSP00000029562
NCBI entrez gene - 11444     See in Manteia.
MGI - MGI:87891
RefSeq - NM_009602
RefSeq Peptide - NP_033732
swissprot - A0A0G2JG64
swissprot - Q9ERK7
Ensembl - ENSMUSG00000027950
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrnb2bENSDARG00000017790Danio rerio
 CHRNB2ENSGALG00000002707Gallus gallus
 CHRNB2ENSG00000160716Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chrnb4 / Q8R493 / cholinergic receptor, nicotinic, beta polypeptide 4 / P30926* / cholinergic receptor nicotinic beta 4 subunit*ENSMUSG0000003520060
Chrna4 / O70174 / cholinergic receptor, nicotinic, alpha polypeptide 4 / P43681* / cholinergic receptor nicotinic alpha 4 subunit*ENSMUSG0000002757749
Chrna2 / Q91X60 / cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) / Q15822* / cholinergic receptor nicotinic alpha 2 subunit*ENSMUSG0000002204147
Chrna3 / cholinergic receptor, nicotinic, alpha polypeptide 3 / P32297* / cholinergic receptor nicotinic alpha 3 subunit*ENSMUSG0000003230345
Chrna6 / Q9R0W9 / cholinergic receptor, nicotinic, alpha polypeptide 6 / Q15825* / cholinergic receptor nicotinic alpha 6 subunit*ENSMUSG0000003149142
Chrna1 / P04756 / cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) / P02708* / cholinergic receptor nicotinic alpha 1 subunit*ENSMUSG0000002710739
Chrnb3 / Q8BMN3 / cholinergic receptor, nicotinic, beta polypeptide 3 / Q05901* / cholinergic receptor nicotinic beta 3 subunit*ENSMUSG0000003149237
Chrna5 / Q2MKA5 / cholinergic receptor, nicotinic, alpha polypeptide 5 / P30532* / cholinergic receptor nicotinic alpha 5 subunit*ENSMUSG0000003559436


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR032932  Neuronal acetylcholine receptor subunit beta-2
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001508 action potential IMP
 biological_processGO:0001661 conditioned taste aversion IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IGI
 biological_processGO:0006939 smooth muscle contraction IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007271 synaptic transmission, cholinergic IEA
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0007612 learning IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008306 associative learning IGI
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0014059 regulation of dopamine secretion IMP
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0021562 vestibulocochlear nerve development IMP
 biological_processGO:0021631 optic nerve morphogenesis IMP
 biological_processGO:0021771 lateral geniculate nucleus development IMP
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IMP
 biological_processGO:0021955 central nervous system neuron axonogenesis IMP
 biological_processGO:0030890 positive regulation of B cell proliferation IGI
 biological_processGO:0032225 regulation of synaptic transmission, dopaminergic IMP
 biological_processGO:0032226 positive regulation of synaptic transmission, dopaminergic IMP
 biological_processGO:0033603 positive regulation of dopamine secretion IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035095 behavioral response to nicotine IEA
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0042053 regulation of dopamine metabolic process IMP
 biological_processGO:0042113 B cell activation IMP
 biological_processGO:0042220 response to cocaine IMP
 biological_processGO:0042320 regulation of circadian sleep/wake cycle, REM sleep IMP
 biological_processGO:0042391 regulation of membrane potential IMP
 biological_processGO:0045188 regulation of circadian sleep/wake cycle, non-REM sleep IMP
 biological_processGO:0045471 response to ethanol IMP
 biological_processGO:0045759 negative regulation of action potential IMP
 biological_processGO:0048814 regulation of dendrite morphogenesis IMP
 biological_processGO:0050877 nervous system process IEA
 biological_processGO:0050890 cognition IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051899 membrane depolarization IMP
 biological_processGO:0051963 regulation of synapse assembly IMP
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060084 synaptic transmission involved in micturition IGI
 biological_processGO:0095500 acetylcholine receptor signaling pathway IEA
 biological_processGO:1905144 response to acetylcholine IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005892 acetylcholine-gated channel complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0044853 plasma membrane raft IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0015464 acetylcholine receptor activity IEA
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity ISO
 molecular_functionGO:0042166 acetylcholine binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000054 delayed ear emergence "late onset of the growth of the outer ear" [J:49421]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0000422 delayed hair appearance "late onset of the first appearance of the fur" [J:17792]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0000539 distended urinary bladder "stretched musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0000540 abnormal urinary bladder epithelium morphology "malformation of the epithelial layer of the urinary bladder" [MGI:tc]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0000904 abnormal superior colliculus "dysmorphology or disorganization of the paired superior eminence of the mesencephalic tectum that is involved in auditory processing" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Chrnb2tm1Jpc/Chrnb2tm1Jpc
Genetic Background: B6.129P2-Chrnb2tm1Jpc

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Thy1-FBXL2)Wata/Gt(ROSA)26Sor+,Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Unc79Lwt/Unc79+
Genetic Background: B6.D2-Unc79Lwt

Allelic Composition: Chrnb2tm1.1Cont/Chrnb2tm1.1Cont
Genetic Background: B6.129-Chrnb2tm1.1Cont

Allelic Composition: Chrnb2tm1.1Cont/Chrnb2+
Genetic Background: B6.129-Chrnb2tm1.1Cont

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Chrna7tm1Bay/Chrna7tm1Bay,Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Chrnb2tm1.1Cont/Chrnb2tm1.1Cont
Genetic Background: B6.129-Chrnb2tm1.1Cont

Allelic Composition: Chrnb2tm1.1Cont/Chrnb2+
Genetic Background: B6.129-Chrnb2tm1.1Cont

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Thy1-FBXL2)Wata/Gt(ROSA)26Sor+,Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Thy1-FBXL2)Wata/Gt(ROSA)26Sor+,Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chrnb2tm1Jpc/Chrnb2tm1Jpc
Genetic Background: B6.129P2-Chrnb2tm1Jpc

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clcc1m1J/Clcc1m1J
Genetic Background: C3H/HeSnJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chrnb2tm1.1Cont/Chrnb2tm1.1Cont
Genetic Background: B6.129-Chrnb2tm1.1Cont

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Chrnb2tm1Jpc/Chrnb2tm1Jpc
Genetic Background: B6.129P2-Chrnb2tm1Jpc

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chrnb2tm1Mdb/Chrnb2tm1Mdb,Chrnb4tm1Mdb/Chrnb4tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chrnb2tm1Jpc/Chrnb2tm1Jpc
Genetic Background: B6.129P2-Chrnb2tm1Jpc

 MP:0002313 abnormal tidal volume "anomaly in the volume of air inspired or expired during each normal respiratory cycle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Thy1-FBXL2)Wata/Gt(ROSA)26Sor+,Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0002338 abnormal pulmonary ventilation "anomaly in the total volume of gas per minute inspired or expired " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Thy1-FBXL2)Wata/Gt(ROSA)26Sor+,Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002546 mydriasis "dilation of one or both pupils" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Thy1-FBXL2)Wata/Gt(ROSA)26Sor+,Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0003280 urinary incontinence "inability to control the urinary excretory functions" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0003290 hypoperistalsis "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chrna7tm1Bay/Chrna7tm1Bay,Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Chrnb2tm1.1Cont/Chrnb2tm1.1Cont
Genetic Background: B6.129-Chrnb2tm1.1Cont

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Chrna7tm1Bay/Chrna7tm1Bay,Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004165 abnormal lateral geniculate nucleus morphology "any malformation or absence of the group of neurons that serve as the primary processor of visual information received from the retina via the optic tract and send processed information to the visual cortex of the occipital lobe" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Chrnb2tm1Jpc/Chrnb2tm1Jpc
Genetic Background: B6.129P2-Chrnb2tm1Jpc

Allelic Composition: Chrnb2tm1Jpc/Chrnb2tm1Jpc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chrnb2tm1Jpc/Chrnb2tm1Jpc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chrnb2tm1.1Cont/Chrnb2tm1.1Cont
Genetic Background: B6.129-Chrnb2tm1.1Cont

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chrnb2tm1Jpc/Chrnb2tm1Jpc
Genetic Background: B6.129P2-Chrnb2tm1Jpc

Allelic Composition: Chrnb2tm1Jpc/Chrnb2tm1Jpc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chrnb2tm1Jpc/Chrnb2tm1Jpc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Thy1-FBXL2)Wata/Gt(ROSA)26Sor+,Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0005176 eyelids fail to open "eyes remain shut throughout life" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Thy1-FBXL2)Wata/Gt(ROSA)26Sor+,Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

Allelic Composition: Chrnb2tm1Mdb/Chrnb2tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005575 increased pulmonary ventilation "greater than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Thy1-FBXL2)Wata/Gt(ROSA)26Sor+,Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0005585 increased tidal volume "greater than the normal volume of air inspired or expired during each normal respiratory cycle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Thy1-FBXL2)Wata/Gt(ROSA)26Sor+,Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0006149 blurred vision "loss of visiual acuity or ability to distinguish small details" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Chrnb2tm1Jpc/Chrnb2tm1Jpc
Genetic Background: B6.129P2-Chrnb2tm1Jpc

 MP:0006243 abnormal pupil dilation reaction to light "the pupil fails to constrict fully when exposed to bright light" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0006276 abnormal autonomic nervous system physiology "anomaly in the function of the sensory and motor neurons that run between the central nervous system (especially the hypothalamus and medulla oblongata) and various internal organs (heart, lungs, endocrine and exocrine glands), responsible for controling involuntary bodily functions" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0009436 fragmentation of sleep/wake states "short bouts of sleep/wake stages with an increased number of transitions among these stages compared to controls" [PMID:19246384]
Show

Allelic Composition: Chrnb2tm1.1Cont/Chrnb2tm1.1Cont
Genetic Background: B6.129-Chrnb2tm1.1Cont

 MP:0009475 abnormal nicotine-mediated receptor currents "change in the measured amplitude, current density or duration of response to stimulation of nicotinic receptors" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Chrnb2tm1Jpc/Chrnb2tm1Jpc
Genetic Background: B6.129P2-Chrnb2tm1Jpc

 MP:0009646 urinary bladder inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the urinary bladder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Thy1-FBXL2)Wata/Gt(ROSA)26Sor+,Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0010386 abnormal urinary bladder physiology "any functional anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Chrnb2tm1Mdb/Chrnb2tm1Mdb,Chrnb4tm1Mdb/Chrnb4tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Chrnb2tm1Mdb/Chrnb2tm1Mdb,Chrnb4tm1Mdb/Chrnb4tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0011179 decreased erythroblast number "reduced number of the nucleated precursor of erythrocytes" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Thy1-FBXL2)Wata/Gt(ROSA)26Sor+,Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0011620 abnormal habituation to a new environment "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a new environment" [MGI:csmith]
Show

Allelic Composition: Chrnb2tm1.1Cont/Chrnb2tm1.1Cont
Genetic Background: B6.129-Chrnb2tm1.1Cont

 MP:0011625 cystolithiasis "caliculi, or a solid concretion or crystal aggregation, found in the urinary bladder; often embedded in a glycoprotein matrix which may also contain some nonglycoproteins when associated with infection" [MGI:csmith]
Show

Allelic Composition: Chrnb2tm1Mdb/Chrnb2tm1Mdb,Chrnb4tm1Mdb/Chrnb4tm1Mdb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0012306 enhanced spatial learning "enhanced ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
Show

Allelic Composition: Chrnb2tm1Jpc/Chrnb2tm1Jpc
Genetic Background: involves: 129P2/OlaHsd

 MP:0012349 increased susceptibility to induction of seizure by inducing agent "lower threshold to induction of seizure activity response by an agent that normally can induce uncontrolled electrical activity in the brain, producing a physical convulsion and/or minor change in physical behavior" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Chrnb2tm1.1Cont/Chrnb2tm1.1Cont
Genetic Background: B6.129-Chrnb2tm1.1Cont

Allelic Composition: Chrnb2tm1.1Cont/Chrnb2+
Genetic Background: B6.129-Chrnb2tm1.1Cont

 MP:0020160 abnormal behavioral response to nicotine "any anomaly in the behavioral response induced by nicotine, such as induced hyperactivity or stereotypic behavior" [GOC:NV]
Show

Allelic Composition: Chrnb2tm1.1Cont/Chrnb2tm1.1Cont
Genetic Background: B6.129-Chrnb2tm1.1Cont

Allelic Composition: Chrnb2tm1.1Cont/Chrnb2+
Genetic Background: B6.129-Chrnb2tm1.1Cont

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027577 Chrna4 / O70174 / cholinergic receptor, nicotinic, alpha polypeptide 4 / P43681* / cholinergic receptor nicotinic alpha 4 subunit*  / complex
 ENSMUSG00000027950 Chrnb2 / Q9ERK7 / cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) / P17787* / cholinergic receptor nicotinic beta 2 subunit*  / complex
 ENSMUSG00000032303 Chrna3 / cholinergic receptor, nicotinic, alpha polypeptide 3 / P32297* / cholinergic receptor nicotinic alpha 3 subunit*  / complex
 ENSMUSG00000035594 Chrna5 / Q2MKA5 / cholinergic receptor, nicotinic, alpha polypeptide 5 / P30532* / cholinergic receptor nicotinic alpha 5 subunit*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr