ENSMUSG00000035594


Mus musculus

Features
Gene ID: ENSMUSG00000035594
  
Biological name :Chrna5
  
Synonyms : cholinergic receptor, nicotinic, alpha polypeptide 5 / Chrna5 / Q2MKA5
  
Possible biological names infered from orthology : cholinergic receptor nicotinic alpha 5 subunit / P30532
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 54980880
Gene end: 55007779
  
Corresponding Affymetrix probe sets: 10585484 (MoGene1.0st)   1427401_at (Mouse Genome 430 2.0 Array)   1442035_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150942
Ensembl peptide - ENSMUSP00000091365
Ensembl peptide - ENSMUSP00000149366
NCBI entrez gene - 110835     See in Manteia.
MGI - MGI:87889
RefSeq - NM_176844
RefSeq - XM_006510773
RefSeq Peptide - NP_789814
swissprot - A0A1L1SR97
swissprot - Q2MKA5
Ensembl - ENSMUSG00000035594
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrna5ENSDARG00000003420Danio rerio
 CHRNA5ENSGALG00000003021Gallus gallus
 CHRNA5ENSG00000169684Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chrnb3 / Q8BMN3 / cholinergic receptor, nicotinic, beta polypeptide 3 / Q05901* / cholinergic receptor nicotinic beta 3 subunit*ENSMUSG0000003149265
Chrna2 / Q91X60 / cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) / Q15822* / cholinergic receptor nicotinic alpha 2 subunit*ENSMUSG0000002204152
Chrna4 / O70174 / cholinergic receptor, nicotinic, alpha polypeptide 4 / P43681* / cholinergic receptor nicotinic alpha 4 subunit*ENSMUSG0000002757752
Chrna6 / Q9R0W9 / cholinergic receptor, nicotinic, alpha polypeptide 6 / Q15825* / cholinergic receptor nicotinic alpha 6 subunit*ENSMUSG0000003149149
Chrna3 / cholinergic receptor, nicotinic, alpha polypeptide 3 / P32297* / cholinergic receptor nicotinic alpha 3 subunit*ENSMUSG0000003230348
Chrna1 / P04756 / cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) / P02708* / cholinergic receptor nicotinic alpha 1 subunit*ENSMUSG0000002710745
Chrnb4 / Q8R493 / cholinergic receptor, nicotinic, beta polypeptide 4 / P30926* / cholinergic receptor nicotinic beta 4 subunit*ENSMUSG0000003520044
Chrnb2 / Q9ERK7 / cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) / P17787* / cholinergic receptor nicotinic beta 2 subunit*ENSMUSG0000002795041


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007271 synaptic transmission, cholinergic IBA
 biological_processGO:0007274 neuromuscular synaptic transmission IBA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035094 response to nicotine IMP
 biological_processGO:0035095 behavioral response to nicotine ISO
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0098655 cation transmembrane transport IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005892 acetylcholine-gated channel complex IPI
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0015464 acetylcholine receptor activity ISO
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity IBA
 molecular_functionGO:0042166 acetylcholine binding IBA


Pathways (from Reactome)
Pathway description
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
Show

Allelic Composition: Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

Allelic Composition: Chrna5tm1Mdb/Chrna5tm1Mdb,Chrnb4tm1Mdb/Chrnb4tm1Mdb
Genetic Background: B6.129-Chrnb4tm1Mdb Chrna5tm1Mdb

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027950 Chrnb2 / Q9ERK7 / cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) / P17787* / cholinergic receptor nicotinic beta 2 subunit*  / complex
 ENSMUSG00000032303 Chrna3 / cholinergic receptor, nicotinic, alpha polypeptide 3 / P32297* / cholinergic receptor nicotinic alpha 3 subunit*  / complex
 ENSMUSG00000035200 Chrnb4 / Q8R493 / cholinergic receptor, nicotinic, beta polypeptide 4 / P30926* / cholinergic receptor nicotinic beta 4 subunit*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr