ENSDARG00000007278


Danio rerio

Features
Gene ID: ENSDARG00000007278
  
Biological name :ect2
  
Synonyms : ect2 / epithelial cell transforming 2
  
Possible biological names infered from orthology : Protein ECT2 / Q07139 / Q9H8V3
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 10388303
Gene end: 10456553
  
Corresponding Affymetrix probe sets: Dr.12679.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000144703
Ensembl peptide - ENSDARP00000146880
Ensembl peptide - ENSDARP00000004102
Ensembl peptide - ENSDARP00000076266
Ensembl peptide - ENSDARP00000134213
NCBI entrez gene - 445406     See in Manteia.
RefSeq - NM_001003883
RefSeq - XM_005155720
RefSeq Peptide - NP_001003883
swissprot - A0A0R4IKD5
swissprot - Q6DRB9
swissprot - F1QVS6
ZFIN ID - ZDB-GENE-040831-2
Ensembl - ENSDARG00000007278
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000009157Gallus gallus
 ECT2ENSG00000114346Homo sapiens
 Ect2ENSMUSG00000027699Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
topbp1 / DNA topoisomerase II binding protein 1 / Q6ZQF0* / Q92547* / DNA topoisomerase 2-binding protein 1 *ENSDARG0000005932217


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001357  BRCT domain
 IPR011993  PH-like domain superfamily
 IPR026817  Guanine nucleotide exchange factor Ect2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0000910 cytokinesis IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
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 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary quality , abnormal
midbrain hindbrain boundary decreased thickness , abnormal
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 ZFA:0000084 yolk yolk quality , abnormal
yolk circular , abnormal
yolk grey , abnormal
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 ZFA:0000106 extension extension decreased thickness , abnormal
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 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0001094 whole organism whole organism shape , abnormal
whole organism viability , abnormal
whole organism decreased size , abnormal
whole organism necrotic , abnormal
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 ZFA:0001114 head head flat , abnormal
head necrotic , abnormal
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 ZFA:0001115 trunk trunk curved dorsal , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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