ENSMUSG00000027699


Mus musculus

Features
Gene ID: ENSMUSG00000027699
  
Biological name :Ect2
  
Synonyms : Ect2 / Protein ECT2 / Q07139
  
Possible biological names infered from orthology : epithelial cell transforming 2 / Q9H8V3
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: A3
Gene start: 27097222
Gene end: 27153878
  
Corresponding Affymetrix probe sets: 10497520 (MoGene1.0st)   1419513_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139341
Ensembl peptide - ENSMUSP00000103933
Ensembl peptide - ENSMUSP00000103935
Ensembl peptide - ENSMUSP00000134744
Ensembl peptide - ENSMUSP00000134786
Ensembl peptide - ENSMUSP00000135208
Ensembl peptide - ENSMUSP00000135617
Ensembl peptide - ENSMUSP00000135630
Ensembl peptide - ENSMUSP00000135740
NCBI entrez gene - 13605     See in Manteia.
MGI - MGI:95281
RefSeq - XM_006535386
RefSeq - NM_001177625
RefSeq - NM_001177626
RefSeq - NM_007900
RefSeq - XM_006535385
RefSeq Peptide - NP_001171097
RefSeq Peptide - NP_031926
RefSeq Peptide - NP_001171096
swissprot - H3BK10
swissprot - H3BL18
swissprot - H3BL29
swissprot - Q07139
swissprot - H3BIZ5
swissprot - V9GXV8
swissprot - H3BIW1
Ensembl - ENSMUSG00000027699
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ect2ENSDARG00000007278Danio rerio
 ENSGALG00000009157Gallus gallus
 ECT2ENSG00000114346Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6ZQF0 / Topbp1 / DNA topoisomerase 2-binding protein 1 / Q92547* / DNA topoisomerase II binding protein 1*ENSMUSG0000003255518


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001357  BRCT domain
 IPR011993  PH-like domain superfamily
 IPR026817  Guanine nucleotide exchange factor Ect2
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036420  BRCT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis ISO
 biological_processGO:0000902 cell morphogenesis IDA
 biological_processGO:0000910 cytokinesis IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032147 activation of protein kinase activity ISO
 biological_processGO:0032467 positive regulation of cytokinesis ISO
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042307 positive regulation of protein import into nucleus IDA
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043547 positive regulation of GTPase activity ISS
 biological_processGO:0045666 positive regulation of neuron differentiation IMP
 biological_processGO:0045859 regulation of protein kinase activity ISS
 biological_processGO:0051260 protein homooligomerization ISS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051988 regulation of attachment of spindle microtubules to kinetochore ISO
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide ISO
 biological_processGO:0070830 bicellular tight junction assembly ISS
 biological_processGO:0071277 cellular response to calcium ion ISO
 biological_processGO:0071479 cellular response to ionizing radiation ISS
 biological_processGO:0090630 activation of GTPase activity ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005911 cell-cell junction ISS
 cellular_componentGO:0005923 bicellular tight junction ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0032154 cleavage furrow ISO
 cellular_componentGO:0072686 mitotic spindle ISS
 cellular_componentGO:0097149 centralspindlin complex ISS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity ISS
 molecular_functionGO:0005096 GTPase activator activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017048 Rho GTPase binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISS


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hprtb-m3/Y,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * SEC/1Gn

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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