ENSMUSG00000032555


Mus musculus

Features
Gene ID: ENSMUSG00000032555
  
Biological name :Topbp1
  
Synonyms : DNA topoisomerase 2-binding protein 1 / Q6ZQF0 / Topbp1
  
Possible biological names infered from orthology : DNA topoisomerase II binding protein 1 / Q92547
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 103305215
Gene end: 103350428
  
Corresponding Affymetrix probe sets: 10588294 (MoGene1.0st)   1452241_at (Mouse Genome 430 2.0 Array)   1458480_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035164
Ensembl peptide - ENSMUSP00000140906
Ensembl peptide - ENSMUSP00000140862
Ensembl peptide - ENSMUSP00000139773
NCBI entrez gene - 235559     See in Manteia.
MGI - MGI:1920018
RefSeq - XM_006511707
RefSeq - NM_176979
RefSeq - XM_006511706
RefSeq Peptide - NP_795953
swissprot - A0A087WS55
swissprot - Q6ZQF0
swissprot - A0A087WPG9
swissprot - A0A087WS20
Ensembl - ENSMUSG00000032555
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 topbp1ENSDARG00000059322Danio rerio
 TOPBP1ENSGALG00000034461Gallus gallus
 Q92547ENSG00000163781Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ect2 / Q07139 / Protein ECT2 / Q9H8V3* / epithelial cell transforming 2*ENSMUSG0000002769911


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR036420  BRCT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006270 DNA replication initiation IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IBA
 biological_processGO:0007131 reciprocal meiotic recombination ISA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0033314 mitotic DNA replication checkpoint IBA
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0001673 male germ cell nucleus IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016605 PML body IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crptm1Hjf/Crptm1Hjf,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Crptm1Hjf Ldlrtm1Her

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Topbp1tm1Pmc/Topbp1tm1Pmc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Crptm1Hjf/Crptm1Hjf,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Crptm1Hjf Ldlrtm1Her

Allelic Composition: Topbp1tm1.1Zqw/Topbp1tm1.1Zqw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crptm1Hjf/Crptm1Hjf,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Crptm1Hjf Ldlrtm1Her

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Crptm1Hjf/Crptm1Hjf,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Crptm1Hjf Ldlrtm1Her

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crptm1Hjf/Crptm1Hjf,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Crptm1Hjf Ldlrtm1Her

 MP:0011093 complete embryonic lethality at implantation "death of all organisms of a given genotype in a population at the point of implantation (Mus: E4.5)" [MGI:csmith]
Show

Allelic Composition: Crptm1Hjf/Crptm1Hjf,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Crptm1Hjf Ldlrtm1Her

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Topbp1tm1.1Zqw/Topbp1tm1.1Zqw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Crptm1Hjf/Crptm1Hjf,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Crptm1Hjf Ldlrtm1Her

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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