ENSG00000163781


Homo sapiens

Features
Gene ID: ENSG00000163781
  
Biological name :TOPBP1
  
Synonyms : DNA topoisomerase II binding protein 1 / Q92547 / TOPBP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q22.1
Gene start: 133598175
Gene end: 133662380
  
Corresponding Affymetrix probe sets: 202633_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000260810
Ensembl peptide - ENSP00000458790
Ensembl peptide - ENSP00000493612
NCBI entrez gene - 11073     See in Manteia.
OMIM - 607760
RefSeq - XM_017005637
RefSeq - NM_007027
RefSeq - XM_005247076
RefSeq - XM_011512357
RefSeq - XM_017005636
RefSeq Peptide - NP_008958
swissprot - Q92547
swissprot - I3L1F2
Ensembl - ENSG00000163781
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 topbp1ENSDARG00000059322Danio rerio
 TOPBP1ENSGALG00000034461Gallus gallus
 Q6ZQF0ENSMUSG00000032555Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ECT2 / Q9H8V3 / epithelial cell transforming 2ENSG0000011434611


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR035960  Secretoglobin superfamily
 IPR036420  BRCT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006259 DNA metabolic process TAS
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006270 DNA replication initiation IBA
 biological_processGO:0006281 DNA repair NAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IBA
 biological_processGO:0010212 response to ionizing radiation IDA
 biological_processGO:0033314 mitotic DNA replication checkpoint IBA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0000794 condensed nuclear chromosome IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0001673 male germ cell nucleus IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0016605 PML body IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding TAS
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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