ENSDARG00000059322


Danio rerio

Features
Gene ID: ENSDARG00000059322
  
Biological name :topbp1
  
Synonyms : DNA topoisomerase II binding protein 1 / topbp1
  
Possible biological names infered from orthology : DNA topoisomerase 2-binding protein 1 / Q6ZQF0 / Q92547
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 9693951
Gene end: 9737230
  
Corresponding Affymetrix probe sets: Dr.1783.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000076846
Ensembl peptide - ENSDARP00000116677
Ensembl peptide - ENSDARP00000153880
NCBI entrez gene - 407679     See in Manteia.
RefSeq - NM_001199738
RefSeq Peptide - NP_001186667
swissprot - F1R135
ZFIN ID - ZDB-GENE-060626-1
Ensembl - ENSDARG00000059322
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TOPBP1ENSGALG00000034461Gallus gallus
 Q92547ENSG00000163781Homo sapiens
 Q6ZQF0ENSMUSG00000032555Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ect2 / epithelial cell transforming 2 / Q07139* / Q9H8V3* / Protein ECT2 *ENSDARG0000000727811


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006270 DNA replication initiation IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IBA
 biological_processGO:0033314 mitotic DNA replication checkpoint IBA
 biological_processGO:0060216 definitive hemopoiesis IMP
 biological_processGO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
 cellular_componentGO:0005634 nucleus IDA


Pathways (from Reactome)
Pathway description
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0005023 hematopoietic system hematopoietic system posterior side has fewer parts of type hematopoietic multipotent progenitor cell , abnormal
Show

 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell apoptotic , abnormal
hematopoietic multipotent progenitor cell apoptotic process increased process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr