ENSDARG00000008433


Danio rerio

Features
Gene ID: ENSDARG00000008433
  
Biological name :unc45b
  
Synonyms : Q6DGE9 / unc45b / unc-45 myosin chaperone B
  
Possible biological names infered from orthology : Q8CGY6 / Q8IWX7
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 11204059
Gene end: 11229523
  
Corresponding Affymetrix probe sets: Dr.345.1.S1_at (Zebrafish Array)   NM_153673_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000105497
Ensembl peptide - ENSDARP00000023678
NCBI entrez gene - 266640     See in Manteia.
RefSeq - NM_153673
RefSeq Peptide - NP_705959
swissprot - E9QD76
swissprot - Q6DGE9
ZFIN ID - ZDB-GENE-020919-3
Ensembl - ENSDARG00000008433
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UNC45BENSGALG00000002186Gallus gallus
 Q8IWX7ENSG00000141161Homo sapiens
 Q8CGY6ENSMUSG00000018845Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
unc45a / unc-45 myosin chaperone A / Q99KD5* / Q9H3U1*ENSDARG0000010364354
tomm70a / translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) / Q9CZW5* / TOMM70* / O94826* / Mitochondrial import receptor subunit TOM70 * / translocase of outer mitoc...ENSDARG0000002963910
rpap3 / RNA polymerase II associated protein 3 / Q9H6T3*ENSDARG000000879629
tomm34 / translocase of outer mitochondrial membrane 34 / Q15785*ENSDARG000000015577
spag1a / F1RBN2 / sperm associated antigen 1a / SPAG1* / Q07617* / sperm associated antigen 1*ENSDARG000000040176
ttc1 / tetratricopeptide repeat domain 1 / Q91Z38* / Q99614*ENSDARG000000445675
spag1b / sperm associated antigen 1bENSDARG000000694993


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR011989  Armadillo-like helical
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR016024  Armadillo-type fold
 IPR019734  Tetratricopeptide repeat
 IPR024660  UNC-45/Cro1/She4, central domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030239 myofibril assembly IMP
 biological_processGO:0048738 cardiac muscle tissue development IMP
 biological_processGO:0048747 muscle fiber development IMP
 biological_processGO:0060538 skeletal muscle organ development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0031672 A band IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle non-functional , abnormal
Show

 ZFA:0000035 lens lens structure , abnormal
lens reflectivity , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000076 swim bladder swim bladder aplastic , abnormal
Show

 ZFA:0000084 yolk yolk edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000114 heart heart structure , abnormal
heart edematous , abnormal
Show

 ZFA:0000155 somite somite myofibril morphology , abnormal
somite myofibril loose , abnormal
Show

 ZFA:0000170 basibranchial basibranchial structure , abnormal
basibranchial mislocalised ventrally , abnormal
Show

 ZFA:0000316 basihyal bone basihyal bone decreased length , abnormal
basihyal bone mislocalised ventrally , abnormal
Show

 ZFA:0000407 pectoral girdle pectoral girdle aplastic/hypoplastic , abnormal
Show

 ZFA:0000473 trunk musculature trunk musculature structure , abnormal
trunk musculature disorganized , abnormal
Show

 ZFA:0000488 ceratobranchial bone ceratobranchial bone structure , abnormal
ceratobranchial bone mislocalised ventrally , abnormal
Show

 ZFA:0000610 vertical myoseptum vertical myoseptum malformed , abnormal
Show

 ZFA:0001056 myotome myotome malformed , abnormal
Show

 ZFA:0001094 whole organism whole organism paralysed , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased length , abnormal
Meckels cartilage displaced , abnormal
Meckels cartilage shortened , abnormal
Show

 ZFA:0001319 myocardium myocardium intercalated disc disorganized , abnormal
Show

 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage decreased length , abnormal
palatoquadrate cartilage mislocalised , abnormal
palatoquadrate cartilage shortened , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage structure , abnormal
ceratohyal cartilage mislocalised ventrally , abnormal
ceratohyal cartilage orientation ceratohyal cartilage , abnormal
Show

 ZFA:0001651 sternohyoid sternohyoid displaced , abnormal
Show

 ZFA:0009115 skeletal muscle cell skeletal muscle cell sarcomere structure , abnormal
skeletal muscle cell myofibril disorganized , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell actin filament disorganized , abnormal
slow muscle cell myosin filament disorganized , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell myofibril disorganized , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell myofibril absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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