Manteia

ENSDARG00000008487

Danio rerio

Features

Gene ID:	ENSDARG00000008487

Biological name :	dmd

Synonyms :	dmd / dystrophin

Possible biological names infered from orthology :	P11531 / P11532

Species:	Danio rerio

Chr. number:	1
Strand:	-1
Band:
Gene start:	10824351
Gene end:	11075405

Corresponding Affymetrix probe sets:	Dr.4495.1.S1_a_at (Zebrafish Array) Dr.4495.2.S1_at (Zebrafish Array)

Cross references:	Ensembl peptide - ENSDARP00000118030 Ensembl peptide - ENSDARP00000119934 Ensembl peptide - ENSDARP00000139822 Ensembl peptide - ENSDARP00000003044 Ensembl peptide - ENSDARP00000020769 Ensembl peptide - ENSDARP00000093677 Ensembl peptide - ENSDARP00000110295 NCBI entrez gene - 83773 See in Manteia. RefSeq - NM_001326687 RefSeq - XM_017355863 RefSeq - XM_021475865 RefSeq - XM_021475867 RefSeq - XM_021475868 RefSeq - XM_021475869 RefSeq Peptide - NP_001313616 swissprot - F1QVF5 swissprot - A0A0R4IXX0 swissprot - F1QC58 swissprot - F1QDK4 swissprot - F1QXP9 swissprot - F1R0H8 swissprot - F1R7V2 ZFIN ID - ZDB-GENE-010426-1 Ensembl - ENSDARG00000008487

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
DMD	ENSGALG00000016281	Gallus gallus
DMD	ENSG00000198947	Homo sapiens
Dmd	ENSMUSG00000045103	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
drp2 / dystrophin related protein 2 / Q05AA6* / Q13474*	ENSDARG00000101419	56
dtna / dystrobrevin, alpha / Q9D2N4* / Q9Y4J8*	ENSDARG00000031015	25
dtnbb / dystrobrevin, beta b / DTNB* / O60941* / O70585* / dystrobrevin beta*	ENSDARG00000013020	23
dtnba / dystrobrevin, beta a	ENSDARG00000077694	21
dytn / A2CI97 / casp8l1 / caspase 8, apoptosis-related cysteine peptidase, like 1 / A2CJ06* / A2CI98* / dystrotelin*	ENSDARG00000071025	19
utrn / utrophin / P46939*	ENSDARG00000100222	2

Protein motifs (from Interpro)

Interpro ID	Name
IPR000433	Zinc finger, ZZ-type
IPR001202	WW domain
IPR001589	Actinin-type actin-binding domain, conserved site
IPR001715	Calponin homology domain
IPR002017	Spectrin repeat
IPR011992	EF-hand domain pair
IPR015153	EF-hand domain, type 1
IPR015154	EF-hand domain, type 2
IPR016344	Dystrophin
IPR018159	Spectrin/alpha-actinin
IPR035436	Dystrophin/utrophin

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006936	muscle contraction	IMP
biological_process	GO:0007517	muscle organ development	IMP
biological_process	GO:0007519	skeletal muscle tissue development	IMP
biological_process	GO:0007525	somatic muscle development	IMP
biological_process	GO:0016203	muscle attachment	IMP
biological_process	GO:0045214	sarcomere organization	IMP
biological_process	GO:0048741	skeletal muscle fiber development	IMP
biological_process	GO:0055002	striated muscle cell development	IMP
biological_process	GO:0061053	somite development	IMP
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016010	dystrophin-associated glycoprotein complex	NAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0030054	cell junction	IEA
cellular_component	GO:0042383	sarcolemma	IDA
cellular_component	GO:0045202	synapse	IEA
cellular_component	GO:0045211	postsynaptic membrane	IEA
molecular_function	GO:0002162	dystroglycan binding	IEA
molecular_function	GO:0003779	actin binding	IEA
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Striated Muscle Contraction

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000155	somite	somite myofibril disorganized , abnormal somite degenerate , abnormal somite saccular , abnormal somite myofibril structure , abnormal somite myofibril necrotic , abnormal somite myofibril mononucleate , abnormal somite disorganized , abnormal somite myofibril detached from somite , abnormal	Show
ZFA:0000473	trunk musculature	trunk musculature membrane damage , abnormal trunk musculature relaxation of muscle increased duration , abnormal trunk musculature sarcomere increased diameter , abnormal trunk musculature sarcomere decreased length , abnormal trunk musculature sarcomere decreased diameter , abnormal trunk musculature dystrophic , abnormal trunk musculature quality , abnormal	Show
ZFA:0000610	vertical myoseptum	vertical myoseptum physical object quality , abnormal vertical myoseptum U-shaped , abnormal	Show
ZFA:0001056	myotome	myotome skeletal muscle cell decreased amount , abnormal myotome skeletal muscle cell degeneration , abnormal myotome refractivity , abnormal myotome broken , abnormal myotome skeletal muscle myofibril malformed , abnormal myotome skeletal muscle myofibril disorganized , abnormal myotome skeletal muscle myofibril increased fragility , abnormal myotome skeletal myofibril assembly process quality , ameliorated myotome skeletal myofibril assembly decreased process quality , abnormal myotome sarcomere malformed , abnormal myotome skeletal muscle cell spatial pattern , abnormal myotome degenerate , abnormal myotome muscle cell degenerate , abnormal myotome muscle cell broken , abnormal myotome skeletal muscle degenerate , abnormal myotome sarcolemma disorganized , abnormal	Show
ZFA:0001094	whole organism	whole organism refractivity , abnormal whole organism immobile , abnormal whole organism amount , ameliorated whole organism increased amount , abnormal whole organism decreased amount , abnormal whole organism refractivity , ameliorated whole organism respiratory gaseous exchange process quality , abnormal whole organism respiratory gaseous exchange process quality , ameliorated whole organism dead , abnormal whole organism decreased life span , abnormal whole organism life span , ameliorated whole organism movement quality , abnormal	Show
ZFA:0001117	post-vent region	post-vent region decreased length , abnormal post-vent region kinked , abnormal	Show
ZFA:0005145	muscle	muscle dystrophic , abnormal muscle organization quality , abnormal muscle damaged , abnormal muscle structure , abnormal muscle disorganized , abnormal muscle decreased functionality , abnormal muscle decreased strength , abnormal muscle broken , abnormal muscle myofibril patchy , abnormal muscle refractivity , abnormal muscle mitochondrion morphology , ameliorated muscle mitochondrion increased size , abnormal muscle mitochondrial matrix decreased mass density , abnormal muscle mitochondrial crista morphology , ameliorated muscle mitochondrial crista decreased amount , abnormal muscle sarcomere disorganized , abnormal	Show
ZFA:0005277	skeletal muscle	skeletal muscle atrophied , abnormal skeletal muscle increased accumulation skeletal muscle cell fibrillar collagen trimer, abnormal skeletal muscle neutrophil present , abnormal skeletal muscle neutrophil aggregated , abnormal skeletal muscle broken , abnormal skeletal muscle dystrophic , abnormal skeletal muscle structure , abnormal skeletal muscle structure , ameliorated skeletal muscle disorganized , abnormal skeletal muscle disorganized , ameliorated skeletal muscle deformed , abnormal skeletal muscle decreased strength , abnormal skeletal muscle myofibril attachment quality skeletal muscle muscle tendon junction, ameliorated skeletal muscle myofibril detached from skeletal muscle muscle tendon junction, abnormal	Show
ZFA:0009115	skeletal muscle cell	skeletal muscle cell degenerate , abnormal skeletal muscle cell increased variability of size , abnormal skeletal muscle cell nucleus mislocalised , abnormal skeletal muscle cell myofibril increased contractility , abnormal skeletal muscle cell broken , abnormal skeletal muscle cell detached from myoseptum , abnormal skeletal muscle cell sarcolemma increased permeability , abnormal skeletal muscle cell disorganized , abnormal skeletal muscle cell undulate , abnormal skeletal muscle cell alignment skeletal muscle , abnormal skeletal muscle cell mitochondrion irregular spatial pattern , abnormal skeletal muscle cell mitochondrion broken , abnormal skeletal muscle cell myofibril disorganized , abnormal	Show
ZFA:0009116	slow muscle cell	slow muscle cell detached from myoseptum , abnormal slow muscle cell detached from vertical myoseptum , abnormal slow muscle cell mitochondrion functionality , abnormal slow muscle cell mitochondrion decreased functionality , abnormal slow muscle cell mitochondrial respiratory chain decreased functionality , abnormal	Show
ZFA:0009117	fast muscle cell	fast muscle cell detached from myoseptum , abnormal fast muscle cell mitochondrion swollen , abnormal fast muscle cell mitochondrial respiratory chain decreased functionality , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr