ENSDARG00000015236


Danio rerio

Features
Gene ID: ENSDARG00000015236
  
Biological name :pycr3
  
Synonyms : pycr3 / pyrroline-5-carboxylate reductase 3 / Q5SPD7
  
Possible biological names infered from orthology : Pycrl / Q53H96 / Q9DCC4
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 52529044
Gene end: 52544761
  
Corresponding Affymetrix probe sets: Dr.12235.1.A1_at (Zebrafish Array)   Dr.12235.1.A1_x_at (Zebrafish Array)   Dr.12235.2.A1_a_at (Zebrafish Array)   Dr.12235.2.A1_x_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000131991
Ensembl peptide - ENSDARP00000011713
NCBI entrez gene - 560682     See in Manteia.
RefSeq - NM_001044938
RefSeq Peptide - NP_001038403
swissprot - A0A0R4IFL3
swissprot - Q5SPD7
ZFIN ID - ZDB-GENE-041014-244
Ensembl - ENSDARG00000015236
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PYCR3ENSGALG00000033828Gallus gallus
 PYCR3ENSG00000104524Homo sapiens
 PycrlENSMUSG00000022571Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pycr1b / pyrroline-5-carboxylate reductase 1b / PYCR2* / PYCR1* / Q922W5* / P32322* / Q96C36* / Q922Q4* / AL117348.2* / pyrroline-5-carboxylate reductase 2* / pyrroline-5-carboxylate reduct...ENSDARG0000009863941
pycr1a / pyrroline-5-carboxylate reductase 1a / PYCR2* / PYCR1* / Q922W5* / P32322* / Q96C36* / Q922Q4* / AL117348.2* / pyrroline-5-carboxylate reductase 2* / pyrroline-5-carboxylate reduct...ENSDARG0000010225440


Protein motifs (from Interpro)
Interpro ID Name
 IPR000304  Pyrroline-5-carboxylate reductase
 IPR008927  6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
 IPR016040  NAD(P)-binding domain
 IPR028939  Pyrroline-5-carboxylate reductase, catalytic, N-terminal
 IPR029036  Pyrroline-5-carboxylate reductase, dimerisation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006561 proline biosynthetic process IEA
 biological_processGO:0008652 cellular amino acid biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0055129 L-proline biosynthetic process ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 molecular_functionGO:0004735 pyrroline-5-carboxylate reductase activity ISS
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000155 somite somite morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000015236 pycr3 / Q5SPD7 / pyrroline-5-carboxylate reductase 3 / Pycrl* / Q53H96* / Q9DCC4*  / complex






 

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